公开(公告)号：US20240342125A1

公开(公告)日：2024-10-17

申请号：US18683376

申请日：2022-09-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko FUJITA ,  Nao IWAMOTO ,  Kazuyuki HIROSE ,  Naoyuki UCHIDA

IPC: A61K31/196 ,  A61K9/70

CPC classification number: A61K31/196 ,  A61K9/7061 ,  A61K9/7069

Abstract: A method for inhibiting the generation of diclofenac indolinones in an adhesive patch is provided. This adhesive patch comprises a support body layer and an adhesive layer that is layered on the support body layer. The aforementioned method includes a step for mixing a diclofenac free acid and an adhesive base to acquire an adhesive composition, and a step for shaping the adhesive composition to obtain an adhesive patch. The content of the diclofenac free acid is 0.5-8 mass % on the basis of the total mass of the adhesive layer.