公开(公告)号：US20240342125A1

公开(公告)日：2024-10-17

申请号：US18683376

申请日：2022-09-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko FUJITA ,  Nao IWAMOTO ,  Kazuyuki HIROSE ,  Naoyuki UCHIDA

IPC: A61K31/196 ,  A61K9/70

CPC classification number: A61K31/196 ,  A61K9/7061 ,  A61K9/7069

Abstract: A method for inhibiting the generation of diclofenac indolinones in an adhesive patch is provided. This adhesive patch comprises a support body layer and an adhesive layer that is layered on the support body layer. The aforementioned method includes a step for mixing a diclofenac free acid and an adhesive base to acquire an adhesive composition, and a step for shaping the adhesive composition to obtain an adhesive patch. The content of the diclofenac free acid is 0.5-8 mass % on the basis of the total mass of the adhesive layer.

公开(公告)号：US20230414530A1

公开(公告)日：2023-12-28

申请号：US18035951

申请日：2021-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Nao IWAMOTO

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/407

CPC classification number: A61K9/7046 ,  A61K47/18 ,  A61K31/407

Abstract: Disclosed is a method for inhibiting degradation of asenapine or a pharmaceutically acceptable salt thereof in a patch. The patch comprises an adhesive layer on a base, and the adhesive layer contains an adhesive base and asenapine or a pharmaceutically acceptable salt thereof. The method includes incorporating at least one amine compound selected from the group consisting of monoethanolamine, diethanolamine, diisopropanolamine, isopropanolamine, triethanolamine and meglumine in the adhesive layer.

公开(公告)号：US20230310340A1

公开(公告)日：2023-10-05

申请号：US18036203

申请日：2021-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Nao IWAMOTO

IPC: A61K9/70 ,  A61K31/407 ,  A61K47/18

CPC classification number: A61K9/7069 ,  A61K31/407 ,  A61K47/183

Abstract: Disclosed is a patch in which degradation of asenapine or a pharmaceutically acceptable salt thereof is inhibited. The patch comprises an adhesive layer on a base, wherein the adhesive layer contains an adhesive base, asenapine or a pharmaceutically acceptable salt thereof, and at least one basic amino acid selected from the group consisting of lysine, arginine and histidine, or a pharmaceutically acceptable salt of said basic amino acid.