公开(公告)号：US20220273603A1

公开(公告)日：2022-09-01

申请号：US17682205

申请日：2022-02-28

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K31/222 ,  A61K9/00 ,  A61K47/10 ,  A61K47/02

Abstract: A method for treating hyperhidrosis is disclosed. The method comprises administering a liquid topical preparation to a patient in need thereof. The liquid topical preparation comprises water and oxybutynin or a pharmaceutically acceptable salt thereof. The oxybutynin or pharmaceutically acceptable salt thereof is present in a range of, for example, from 10 mass % to 20 mass % based on a total mass of the liquid topical preparation.

公开(公告)号：US20240342125A1

公开(公告)日：2024-10-17

申请号：US18683376

申请日：2022-09-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko FUJITA ,  Nao IWAMOTO ,  Kazuyuki HIROSE ,  Naoyuki UCHIDA

IPC: A61K31/196 ,  A61K9/70

CPC classification number: A61K31/196 ,  A61K9/7061 ,  A61K9/7069

Abstract: A method for inhibiting the generation of diclofenac indolinones in an adhesive patch is provided. This adhesive patch comprises a support body layer and an adhesive layer that is layered on the support body layer. The aforementioned method includes a step for mixing a diclofenac free acid and an adhesive base to acquire an adhesive composition, and a step for shaping the adhesive composition to obtain an adhesive patch. The content of the diclofenac free acid is 0.5-8 mass % on the basis of the total mass of the adhesive layer.

公开(公告)号：US20250064754A1

公开(公告)日：2025-02-27

申请号：US18941163

申请日：2024-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US20190046493A1

公开(公告)日：2019-02-14

申请号：US16079208

申请日：2016-10-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kana IMAMURA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K31/216 ,  A61K47/14 ,  A61K47/12 ,  A61K47/02 ,  A61K9/00 ,  A61P17/00

Abstract: The present invention provides a liquid topical preparation having low “stickiness” even when it contains a high concentration of an anticholinergic drug. The liquid topical preparation comprises water, an anticholinergic drug and dicarboxylic acid ester, and the content of the anticholinergic drug ranges from 10 mass % to 20 mass % based on the total mass of the liquid topical preparation.

公开(公告)号：US20210251913A1

公开(公告)日：2021-08-19

申请号：US17244552

申请日：2021-04-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US20200000737A1

公开(公告)日：2020-01-02

申请号：US16471692

申请日：2017-12-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko FUJITA ,  Takito SHIMA ,  Kazuya KOMINAMI ,  Naoyuki UCHIDA

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/14 ,  A61K47/10 ,  A61K47/34

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.

公开(公告)号：US20190350874A1

公开(公告)日：2019-11-21

申请号：US16474213

申请日：2017-12-26

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.