公开(公告)号：US11134231B2

公开(公告)日：2021-09-28

申请号：US16199233

申请日：2018-11-26

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Shaoqun Zeng ,  Qinglei Hu ,  Xiaohua Lv ,  Qingming Luo

IPC: H04N9/31

Abstract: The light control device includes a light modulation module and a dispersion compensation module. The light modulation module is used for modulating an incident light field to obtain a target diffraction light field. The dispersion compensation module is used for performing dispersion compensation on the target diffraction light field, so that light fields having different wavelength in the target diffraction light field have the same spatial location distribution, or the light fields having different wavelength in the target diffraction light field have the same spatial angle distribution.

公开(公告)号：US09371364B2

公开(公告)日：2016-06-21

申请号：US14406399

申请日：2013-06-07

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Qingming Luo ,  Zhihong Zhang ,  Haiming Luo

IPC: A61K38/16 ,  C07K14/00 ,  C07K7/08 ,  A61K9/51 ,  A61K31/12 ,  A61K31/337 ,  C07K14/47 ,  A61K47/48 ,  A61K49/00 ,  A61K38/10 ,  A61K47/42

CPC classification number: C07K7/08 ,  A61K9/5123 ,  A61K9/5169 ,  A61K31/12 ,  A61K31/337 ,  A61K38/10 ,  A61K38/16 ,  A61K47/42 ,  A61K47/6425 ,  A61K47/65 ,  A61K47/66 ,  A61K47/6929 ,  A61K49/0093 ,  C07K14/4747 ,  C07K14/4748 ,  C07K2319/00 ,  C07K2319/33 ,  G01N33/57407 ,  G01N33/582 ,  A61K2300/00

Abstract: Disclosed is a dual-targeted therapeutic peptide for nasopharyngeal carcinoma formed by covalently linking a targeted therapeutic peptide for nasopharyngeal carcinoma, a peptide linker and a targeted therapeutic peptide with an α-helical structure for nasopharyngeal carcinoma. Also disclosed is a nanoparticle containing the peptide. The peptide and the nanoparticle can be used to treat nasopharyngeal carcinoma.

Abstract translation: 公开了通过共价连接鼻咽癌靶向治疗肽，肽接头和靶向治疗肽与鼻咽癌α-螺旋结构形成的双靶向治疗肽。 还公开了含有肽的纳米颗粒。 肽和纳米颗粒可用于治疗鼻咽癌。

公开(公告)号：US20150344525A1

公开(公告)日：2015-12-03

申请号：US14406399

申请日：2013-06-07

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Qingming Luo ,  Zhihong Zhang ,  Haiming Luo

IPC: C07K7/08 ,  A61K9/51 ,  A61K31/337 ,  A61K31/12 ,  A61K38/16 ,  A61K49/00

CPC classification number: C07K7/08 ,  A61K9/5123 ,  A61K9/5169 ,  A61K31/12 ,  A61K31/337 ,  A61K38/10 ,  A61K38/16 ,  A61K47/42 ,  A61K47/6425 ,  A61K47/65 ,  A61K47/66 ,  A61K47/6929 ,  A61K49/0093 ,  C07K14/4747 ,  C07K14/4748 ,  C07K2319/00 ,  C07K2319/33 ,  G01N33/57407 ,  G01N33/582 ,  A61K2300/00

Abstract: Disclosed is a dual-targeted therapeutic peptide for nasopharyngeal carcinoma formed by covalently linking a targeted therapeutic peptide for nasopharyngeal carcinoma, a peptide linker and a targeted therapeutic peptide with an α-helical structure for nasopharyngeal carcinoma. Also disclosed is a nanoparticle containing the peptide. The peptide and the nanoparticle can be used to treat nasopharyngeal carcinoma.

Abstract translation: 公开了通过共价连接鼻咽癌靶向治疗肽，肽接头和靶向治疗肽与鼻咽癌α-螺旋结构形成的双靶向治疗肽。 还公开了含有肽的纳米颗粒。 肽和纳米颗粒可用于治疗鼻咽癌。

公开(公告)号：US11346782B2

公开(公告)日：2022-05-31

申请号：US15771713

申请日：2017-10-20

Applicant: Huazhong University of Science and Technology

Inventor： Shaoqun Zeng ,  Qingming Luo ,  Hanqing Xiong ,  Wenyan Guo ,  Xiaohua Lv

IPC: G01N1/00 ,  G01N21/64

Abstract: A tomographic imaging method which includes the steps of activating fluorescence in a surface layer of a protein-marked or fluorescent dye-marked biological tissue sample not emitting fluorescence or only emitting specific fluorescence to acquire an activated surface of biological tissue sample; performing fluorescence excitation on the acquired surface biological tissue sample, and imaging the fluorescence to acquire a fluorescence image of the surface layer; cutting off the surface layer; exposing an inactivated new surface layer after cutting the surface layer; repeatedly performing activating, imaging and cutting off steps for the new surface layer to repeat tomographic imaging in such a manner till acquiring a two-dimensional image of each layer of the biological tissue sample; and overlapping the two-dimensional images to acquire a complete three-dimensional image of the biological tissue sample, thus acquiring three-dimensional structure information of the entire sample.

公开(公告)号：US10197476B2

公开(公告)日：2019-02-05

申请号：US15691698

申请日：2017-08-30

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Hui Gong ,  Jing Yuan ,  Tao Jiang ,  Lei Deng ,  Qingming Luo

IPC: G01N1/06 ,  G01N1/18 ,  G01N1/14 ,  G01N35/10

Abstract: An automatic slicing and collecting device, the device including: a first tank, a vibrating microtome, a first pipeline, and a second pipeline. The first tank is filled with a buffer solution. The vibrating microtome is disposed in the first tank. One end of the first pipeline is connected to the vibrating microtome to collect sections, and the other end of the first pipeline is connected to a pump. The pump includes a reversible motor. The first pipeline is provided with a first valve, and a filter is disposed between the pump and the first pipeline. One end of the second pipeline is disposed between the first valve of the first pipeline and the pump, and the second pipeline is provided with a second valve.