公开(公告)号：US5015755A

公开(公告)日：1991-05-14

申请号：US391957

申请日：1989-08-10

申请人： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

发明人： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

IPC分类号： C07D207/16 ,  A61K49/00 ,  C07B57/00 ,  C07B63/02 ,  C07C33/18 ,  C07C67/00 ,  C07C69/96 ,  C07C201/00 ,  C07C205/43 ,  C07C227/40 ,  C07C229/36 ,  C07C241/00 ,  C07C247/20 ,  C07C247/22 ,  C07C281/02 ,  C07D207/404 ,  C07D207/416 ,  C07D255/02

CPC分类号： C07C69/96 ,  C07C227/34 ,  C07C33/18 ,  C07C2103/24 ,  Y10S435/968 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/204998

摘要： New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.

公开(公告)号：US5128120A

公开(公告)日：1992-07-07

申请号：US650868

申请日：1991-02-05

申请人： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

发明人： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

IPC分类号： C07D207/16 ,  A61K49/00 ,  C07B57/00 ,  C07B63/02 ,  C07C33/18 ,  C07C67/00 ,  C07C69/96 ,  C07C201/00 ,  C07C205/43 ,  C07C227/40 ,  C07C229/36 ,  C07C241/00 ,  C07C247/20 ,  C07C247/22 ,  C07C281/02 ,  C07D207/404 ,  C07D207/416 ,  C07D255/02

CPC分类号： C07C69/96 ,  C07C227/34 ,  C07C33/18 ,  C07C2103/24 ,  Y10S435/968 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/204998

摘要： New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.

摘要翻译： 具有通式“IMAGE”的新的9-蒽基烷基化合物，其中R是氢或烷基，其中R不多于一个是烷基; R1是氢，低级烷基，卤素或硝基; n为1〜7的整数，但-CHR-（CHR）n-基团中的碳原子总数不超过8; X为卤素，叠氮基或琥珀酰亚胺基。 新化合物由与蒽化合物X-CO-X反应的9-蒽醇制备，其中X为卤素，然后任选与化合物反应，得到叠氮化物或琥珀酰亚胺基。 该化合物用作分离和检测目的的衍生试剂。 制备其中一个R为烷基的上述定义的9-蒽基烷基化合物的中间体是具有基团-CHR-（CHR）n -OH的9-蒽基，其中一个R为烷基。