公开(公告)号：US20050096478A1

公开(公告)日：2005-05-05

申请号：US10999698

申请日：2004-11-29

Applicant: Dennis Curran ,  Roger Read ,  Zhiyong Luo

Inventor： Dennis Curran ,  Roger Read ,  Zhiyong Luo

IPC: C07C69/96 ,  C07C237/22 ,  C07C237/42 ,  C07C247/20 ,  C07C255/61 ,  C07C255/62 ,  C07C269/04 ,  C07C271/08 ,  C07D207/14 ,  C07D207/16 ,  C07D211/62 ,  C07D213/40 ,  C07D217/06 ,  C07D401/06 ,  C07D405/06 ,  C07F7/04

CPC classification number: C07D213/40 ,  C07C69/96 ,  C07C237/22 ,  C07C237/42 ,  C07C255/62 ,  C07D207/14 ,  C07D207/16 ,  C07D211/62 ,  C07D217/06 ,  C07D401/06 ,  C07D405/06 ,  Y10T436/13 ,  Y10T436/19

Abstract: A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having the formula: wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, Ra is an alkyl group and X is a suitable leaving group. A compound has the formula: wherein Rf is a fluorous group, n is an integer between 0 and 6, m is 1, 2 or 3, Ra is an alkyl group and X is a leaving group.

Abstract translation: 增加化合物的氟性质的方法包括使化合物与至少一种具有下式的第二化合物反应的步骤：其中Rf是氟基，Rs是间隔基，d是1或0，m是1， 2或3，Ra是烷基，X是合适的离去基团。 化合物具有下式：其中Rf是氟基，n是0和6之间的整数，m是1,2或3，Ra是烷基，X是离去基团。

公开(公告)号：US3993682A

公开(公告)日：1976-11-23

申请号：US572224

申请日：1975-04-28

Applicant: Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

Inventor： Heinrich Kolling ,  Herbert Thomas ,  Arno Widdig ,  Hartmund Wollweber

IPC: A61K31/27 ,  A61K31/155 ,  A61K31/16 ,  A61K31/165 ,  A61P33/00 ,  A61P33/10 ,  B01D45/04 ,  B01D47/06 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/43 ,  C07C241/00 ,  C07C247/20 ,  C07C277/08 ,  C07C279/20 ,  C07C279/24 ,  C07C313/00 ,  C07C315/02 ,  C07C315/04 ,  C07C317/40 ,  C07C317/42 ,  C07C317/44 ,  C07C317/46 ,  C07C317/50 ,  C07C323/43 ,  C07C323/44 ,  C07C149/40

CPC classification number: B01D45/04 ,  A61K31/155 ,  B01D47/06

Abstract: N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.

Abstract translation: 在2-（取代的酰氨基）苯甲酸的4-或5-位上带有任选取代的苯氧基，苯硫基，苯基亚磺酰基或苯基磺酰基的N- [2-（取代的酰胺基）苯基] -N'，N“ - 双 - 羰基胍 苯基是驱肠剂。 其中N-（2-乙酰氨基-4-苯硫基苯基）-N'，N“ - 双 - 甲酯基胍的化合物是典型的例子，通过异硫脲-S-烷基醚和适当取代的2- 氨基苯胺。

公开(公告)号：US20050002835A1

公开(公告)日：2005-01-06

申请号：US10836250

申请日：2004-05-03

Applicant: John Shaw ,  Richard Shute

Inventor： John Shaw ,  Richard Shute

IPC: B01F3/20 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01J19/12 ,  C07B61/00 ,  C07C2/42 ,  C07C13/44 ,  C07C243/26 ,  C07C247/20 ,  C07C247/22 ,  C07C263/12 ,  C07C273/18 ,  C40B60/14

CPC classification number: C40B60/14 ,  B01F3/20 ,  B01F3/2035 ,  B01F3/2085 ,  B01F5/06 ,  B01F13/0001 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/0031 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00871 ,  B01J2219/00943 ,  C07C247/22 ,  C07C273/1809

Abstract: A chemical reactor and method of using the same. The reactor comprises first and second micro-engineered discrete flow passages for receiving chemical fluids. The first fluid passage receives a first chemical fluid in which a chemical change or reaction in the fluid can be initiated by subjecting the fluid to a stimulus. A stimulation means is located in, or adjacent to, the first flow passage, and is operable to stimulate a chemical change or reaction in the first fluid. The second micro-engineered discrete flow passage receives a second chemical fluid which will interact with the stimulated first fluid when contacted by the stimulated first fluid. The first and second flow passages converge at a first region to form an outlet passage within which the first and second fluids may contact each other.

Abstract translation: 一种化学反应器及其使用方法。 反应器包括用于接收化学流体的第一和第二微型工程离散流动通道。 第一流体通道接收第一化学流体，其中可以通过使流体经受刺激来引发流体中的化学变化或反应。 刺激装置位于或邻近第一流动通道，并且可操作以刺激第一流体中的化学变化或反应。 第二微型工程离散流动通道接收第二化学流体，当被受刺激的第一流体接触时，该第二化学流体将与受刺激的第一流体相互作用。 第一和第二流动通道在第一区域处会聚，以形成第一和第二流体可以彼此接触的出口通道。

公开(公告)号：US5128120A

公开(公告)日：1992-07-07

申请号：US650868

申请日：1991-02-05

Applicant: Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

Inventor： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

IPC: C07D207/16 ,  A61K49/00 ,  C07B57/00 ,  C07B63/02 ,  C07C33/18 ,  C07C67/00 ,  C07C69/96 ,  C07C201/00 ,  C07C205/43 ,  C07C227/40 ,  C07C229/36 ,  C07C241/00 ,  C07C247/20 ,  C07C247/22 ,  C07C281/02 ,  C07D207/404 ,  C07D207/416 ,  C07D255/02

CPC classification number: C07C69/96 ,  C07C227/34 ,  C07C33/18 ,  C07C2103/24 ,  Y10S435/968 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/204998

Abstract: New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.

Abstract translation: 具有通式“IMAGE”的新的9-蒽基烷基化合物，其中R是氢或烷基，其中R不多于一个是烷基; R1是氢，低级烷基，卤素或硝基; n为1〜7的整数，但-CHR-（CHR）n-基团中的碳原子总数不超过8; X为卤素，叠氮基或琥珀酰亚胺基。 新化合物由与蒽化合物X-CO-X反应的9-蒽醇制备，其中X为卤素，然后任选与化合物反应，得到叠氮化物或琥珀酰亚胺基。 该化合物用作分离和检测目的的衍生试剂。 制备其中一个R为烷基的上述定义的9-蒽基烷基化合物的中间体是具有基团-CHR-（CHR）n -OH的9-蒽基，其中一个R为烷基。

公开(公告)号：US5015755A

公开(公告)日：1991-05-14

申请号：US391957

申请日：1989-08-10

Applicant: Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

Inventor： Hans-Dieter Becker ,  Stefan Einarsson ,  Andrzej Grzegorczyk ,  Bjorn Josefsson ,  Stig S. Lagerkvist ,  Per L. Moller ,  Domingo Sanchez ,  Johan H. Sorensen

IPC: C07D207/16 ,  A61K49/00 ,  C07B57/00 ,  C07B63/02 ,  C07C33/18 ,  C07C67/00 ,  C07C69/96 ,  C07C201/00 ,  C07C205/43 ,  C07C227/40 ,  C07C229/36 ,  C07C241/00 ,  C07C247/20 ,  C07C247/22 ,  C07C281/02 ,  C07D207/404 ,  C07D207/416 ,  C07D255/02

CPC classification number: C07C69/96 ,  C07C227/34 ,  C07C33/18 ,  C07C2103/24 ,  Y10S435/968 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/173845 ,  Y10T436/203332 ,  Y10T436/204998

Abstract: New 9-anthrylalkyl compounds having the general formula ##STR1## wherein R is hydrogen or an alkyl group, whereby, however, not more than one of the groups R is an alkyl group; R.sub.1 is hydrogen, lower alkyl, halogen or nitro; n is an integer of from 1 to 7, whereby, however, the total number of carbon atoms in the group --CHR--(CHR).sub.n -- does not exceed 8; and X is halogen, an azide group or a succinimidyl group.The new compounds are prepared from 9-anthrylalcohols which are reacted with a compound X--CO--X wherein X is a halogen, and then optionally with compounds giving azide or succinimidyl group. The compounds are used as derivatization reagents for separation and detection purposes.Intermediates for preparation of the above defined 9-anthrylalkyl compounds wherein one R is an alkyl group are 9-anthrylalcohols with the group --CHR--(CHR).sub.n --OH, wherein one R is an alkyl group.

公开(公告)号：US4228086A

公开(公告)日：1980-10-14

申请号：US22714

申请日：1979-03-21

Applicant: Gerhard Eisenbrand

Inventor： Gerhard Eisenbrand

IPC: A61K31/165 ,  A61K31/17 ,  A61K31/195 ,  A61K31/22 ,  A61K31/255 ,  A61P35/00 ,  C07C67/00 ,  C07C239/00 ,  C07C247/20 ,  C07C269/06 ,  C07C271/60 ,  C07C275/04 ,  C07C275/66 ,  C07C275/68 ,  C07C281/06 ,  C07C301/00 ,  C07C303/28 ,  C07C305/00 ,  C07C309/66 ,  C07C117/00

CPC classification number: A61K31/17

Abstract: The invention relates to the preparation of novel N-substituted alkyl-N-nitrosocarbamoyl azides and to the compounds obtained thereby. The novel N-substituted alkyl-N-nitrosocarbamoyl azides can be reacted with amines, diamines, aminoalcohols, aminoacids or aminoacid derivatives to prepare unsymmetrically 1,3-disubstituted nitrosoureas which show therapeutical activity.

Abstract translation: 本发明涉及新型N-取代烷基-N-亚硝基氨基甲酰基叠氮化物的制备及其制备。 新的N-取代的烷基-N-亚硝基氨基甲酰基叠氮化物可以与胺，二胺，氨基醇，氨基酸或氨基酸衍生物反应，以制备显示出治疗活性的不对称的1,3-二取代的亚硝基脲。

公开(公告)号：US4150146A

公开(公告)日：1979-04-17

申请号：US800452

申请日：1977-05-25

Applicant: Gerhard Eisenbrand

Inventor： Gerhard Eisenbrand

IPC: A61K31/165 ,  A61K31/17 ,  A61K31/195 ,  A61K31/22 ,  A61K31/255 ,  A61P35/00 ,  C07C67/00 ,  C07C239/00 ,  C07C247/20 ,  C07C269/06 ,  C07C271/60 ,  C07C275/04 ,  C07C275/66 ,  C07C275/68 ,  C07C281/06 ,  C07C301/00 ,  C07C303/28 ,  C07C305/00 ,  C07C309/66

CPC classification number: A61K31/17

Abstract: The invention relates to the preparation of unsymmetrically 1,3-disubstituted nitroso ureas from the corresponding N-substituted alkyl-N-nitrosocarbamoyl azide which is reacted with an amine, a diamine, an aminoalcohol, an aminoacid or an aminoacid derivative. The N-nitrosocarbamoyl azide is obtained by reacting the corresponding alkylcarbamoyl azide with nitrogen tetroxide in the cold. The alkylcarbamoyl azide is obtained by reacting the corresponding isocyanate with an alkali metal azide.The invention further relates to novel nitroso ureas obtained thereby, to novel N-substituted alkyl-N-nitrosocarbamoyl azides, and to novel therapeutic compositions containing, as the active ingredient, the novel nitroso ureas.

Abstract translation: 本发明涉及从与胺，二胺，氨基醇，氨基酸或氨基酸衍生物反应的相应的N-取代的烷基-N-亚硝基氨基甲酰基叠氮化物制备不对称的1,3-二取代的亚硝基脲。 N-亚硝基氨基甲酰基叠氮化物是通过使冷却下的相应的烷基氨基甲酰基叠氮化物与四氧化氮反应得到的。 烷基氨基甲酰基叠氮化物通过使相应的异氰酸酯与碱金属叠氮化物反应而获得。