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公开(公告)号：US20060128736A1
公开(公告)日：2006-06-15
申请号：US10519193
申请日：2003-06-26
申请人： Heinrich Haas , Brita Schulze , Uwe Michaelis , Michael Teifel , Birgitta Sauer , Thomas Fichert
发明人： Heinrich Haas , Brita Schulze , Uwe Michaelis , Michael Teifel , Birgitta Sauer , Thomas Fichert
IPC分类号： A61K31/4745
CPC分类号： A61K31/47 , A61K9/1272 , A61K31/335 , A61K31/4745 , A61K47/34 , A61K47/541 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： The present invention relates to compositions, particularly colloidal nanoaggregates comprising the carboxylate form of a campothecin drug or a derivative thereof associated with at least one organic cationic molecule, which has a positive net charge. The composition or nanoaggregate may be present as an emulsion, droplet, mincelle, liposome, nanoparticle or nanocapsule.
摘要翻译： 本发明涉及组合物，特别是包含与至少一种有机阳离子分子缔合的营养不良的羧酸盐形式的氨基辛酸或其衍生物的胶体纳米聚集体，其具有正的净电荷。 组合物或纳米聚集体可以乳液，液滴，分解，脂质体，纳米颗粒或纳米胶囊存在。
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2.发明申请Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system 审中-公开在阳离子载体体系中稳定诊断和治疗化合物的新方法公开(公告)号：US20050181038A1
公开(公告)日：2005-08-18
申请号：US11018575
申请日：2004-12-22
申请人： Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel
发明人： Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel
IPC分类号： A61K47/18 , A61K9/127 , A61K31/00 , A61K31/335 , A61K31/337 , A61K31/47 , A61K31/4745 , A61K47/24 , A61K47/28 , A61K47/34 , A61K47/48 , A61K49/00 , A61K49/18 , A61K51/12 , A61P9/00 , A61P11/06 , A61P17/02 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/00 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/186 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00
摘要： The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
摘要翻译： 本发明涉及在阳离子脂质体中稳定低分子量化合物的方法，其中所述化合物在脂质膜中的溶解度低，和/或脂质膜上的低渗透性。 优选地，化合物被修饰以增加脂质膜溶解度和/或脂质膜渗透性。 将阳离子脂质体递送到靶位点，特别是生物体中的靶位点后，修饰被逆转，低分子量化合物可以产生其所需的活性。
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3.发明申请Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system 审中-公开在阳离子载体体系中稳定诊断和治疗化合物的新方法公开(公告)号：US20100178243A1
公开(公告)日：2010-07-15
申请号：US12654523
申请日：2009-12-22
申请人： Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel
发明人： Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel
IPC分类号： A61K9/127 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12 , A61K49/00 , A61K38/43 , A61K31/337 , A61K31/475 , A61P35/00
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/00 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/186 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00
摘要： The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
摘要翻译： 本发明涉及在阳离子脂质体中稳定低分子量化合物的方法，其中所述化合物在脂质膜中的溶解度低，和/或脂质膜上的低渗透性。 优选地，化合物被修饰以增加脂质膜溶解度和/或脂质膜渗透性。 将阳离子脂质体递送到靶位点，特别是生物体中的靶位点后，修饰被逆转，低分子量化合物可以产生其所需的活性。
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4.发明申请Method of Producing A Cationic Liposomal Preparation Comprising A Lipophilic Compound 有权产生包含亲脂性化合物的阳离子脂质体制备方法公开(公告)号：US20120087975A1
公开(公告)日：2012-04-12
申请号：US13278801
申请日：2011-10-21
申请人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127 , A61K31/337 , A61K31/4375 , A61K31/427 , A61K31/685 , A61K31/56
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译： 公开了一种阳离子脂质体制剂的制备方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。
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公开(公告)号：US20110038926A1
公开(公告)日：2011-02-17
申请号：US12859000
申请日：2010-08-18
申请人： Carsten Mundus , Christain Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christain Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127 , A61K31/337 , A61P35/00
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
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6.发明授权Method of producing a cationic liposomal preparation comprising a lipophilic compound 有权制备包含亲脂性化合物的阳离子脂质体制剂的方法公开(公告)号：US08663606B2
公开(公告)日：2014-03-04
申请号：US13278801
申请日：2011-10-21
申请人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127 , A61K31/685 , A61K31/56 , A61K31/4375 , A61K31/427 , A61K31/337
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译： 公开了一种阳离子脂质体制剂的制造方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。
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7.发明授权Method of producing a cationic liposomal preparation comprising a lipophilic compound 有权制备包含亲脂性化合物的阳离子脂质体制剂的方法公开(公告)号：US08075913B2
公开(公告)日：2011-12-13
申请号：US12859000
申请日：2010-08-18
申请人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译： 公开了一种阳离子脂质体制剂的制造方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。
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8.发明授权Method of producing a cationic liposomal preparation comprising a lipophilic compound 有权制备包含亲脂性化合物的阳离子脂质体制剂的方法公开(公告)号：US07794747B2
公开(公告)日：2010-09-14
申请号：US11018574
申请日：2004-12-22
申请人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christian Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译： 公开了一种阳离子脂质体制剂的制备方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。
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9.发明申请Method of producing a cationic liposomal preparation comprising a lipophilic compound 有权制备包含亲脂性化合物的阳离子脂质体制剂的方法公开(公告)号：US20050202076A1
公开(公告)日：2005-09-15
申请号：US11018574
申请日：2004-12-22
申请人： Carsten Mundus , Christain Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
发明人： Carsten Mundus , Christain Welz , Oliver Schramel , Heinrich Haas , Thomas Fichert , Brita Schulze , Toralf Peymann , Uwe Michaelis , Michael Teifel , Friedrich Gruber , Gerhard Winter
IPC分类号： A61K9/127 , A61K31/335 , A61K31/337 , A61K31/47 , A61K31/4745 , A61K47/24 , A61K47/28 , A61K47/48 , A61K49/18 , A61P35/00 , C07D471/14
CPC分类号： A61K31/337 , A61K9/127 , A61K9/1272 , A61K31/335 , A61K31/47 , A61K31/4745 , A61K47/34 , A61K47/543 , A61K47/56 , A61K47/6911 , A61K49/1812 , B82Y5/00 , C07D471/14
摘要： A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
摘要翻译： 公开了一种阳离子脂质体制剂的制备方法，其包括在制造，储存和重构过程中具有物理和化学稳定性的亲脂性活性化合物，以及可通过该方法获得的阳离子脂质体制剂以及特定的阳离子脂质体制剂以及药物组合物。
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10.发明申请公开(公告)号：US20080063699A1
公开(公告)日：2008-03-13
申请号：US10575779
申请日：2004-10-15
申请人： Michael Teifel , Uwe Michaelis , Birgitta Sauer , Kerstin Bartelheim , Christoph Brunner , Kurt Naujoks
发明人： Michael Teifel , Uwe Michaelis , Birgitta Sauer , Kerstin Bartelheim , Christoph Brunner , Kurt Naujoks
IPC分类号： A61K9/127 , A61K31/337 , A61P17/00 , A61P37/00 , A61K31/7028
CPC分类号： A61K31/335 , A61K9/1272
摘要： The present invention relates to the use of pharmaceutical preparations comprising paclitaxel for administration to a human patient in need thereof.
摘要翻译： 本发明涉及包含紫杉醇的药物制剂在有需要的人类患者中的用途。
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