Liposomal formulations of lipophilic compounds

    公开(公告)号:US10413511B2

    公开(公告)日:2019-09-17

    申请号:US13697906

    申请日:2011-05-20

    IPC分类号: A61K9/127 A61K31/337

    摘要: The present invention relates to the preparation of liposomes with enhanced loading capacity for pharmaceutically and/or diagnostically active agents and/or cosmetic agents which are substantially solubilized by the liposomal membranes, to liposome dispersions with enhanced stability with respect to release of the active agent and/or cosmetic agent from the liposomes obtainable by the process, and to pharmaceutical or cosmetic compositions comprising said stabilized liposome dispersions. The preparation may involve dehydration and rehydration steps of liposome dispersions which may be carried out by spray drying.

    LIPOSOMAL FORMULATIONS OF LIPOPHILIC COMPOUNDS
    5.
    发明申请
    LIPOSOMAL FORMULATIONS OF LIPOPHILIC COMPOUNDS 有权
    脂质化合物的脂质制剂

    公开(公告)号:US20130259922A1

    公开(公告)日:2013-10-03

    申请号:US13697906

    申请日:2011-05-20

    IPC分类号: A61K9/127

    摘要: The present invention relates to the preparation of liposomes with enhanced loading capacity for pharmaceutically and/or diagnostically active agents and/or cosmetic agents which are substantially solubilized by the liposomal membranes, to liposome dispersions with enhanced stability with respect to release of the active agent and/or cosmetic agent from the liposomes obtainable by the process, and to pharmaceutical or cosmetic compositions comprising said stabilized liposome dispersions. The preparation may involve dehydration and rehydration steps of liposome dispersions which may be carried out by spray drying.

    摘要翻译: 本发明涉及对脂质体膜基本溶解的药学和/或诊断活性剂和/或化妆品具有增强的负荷能力的脂质体的制备,涉及相对于活性剂的释放具有增强的稳定性的脂质体分散体, /或来自可通过该方法获得的脂质体的化妆剂,以及包含所述稳定的脂质体分散体的药物或化妆品组合物。 该制剂可能涉及可通过喷雾干燥进行的脂质体分散体的脱水和再水化步骤。

    Securing method, interrogation unit and securing system for implementing the securing method
    7.
    发明授权
    Securing method, interrogation unit and securing system for implementing the securing method 失效
    固定方法,询问单元和固定系统,用于实施安全方法

    公开(公告)号:US07034676B2

    公开(公告)日:2006-04-25

    申请号:US10258005

    申请日:2001-04-04

    IPC分类号: G08B1/08

    摘要: In a method for securing an object against unauthorized use, an interrogation unit (1) transmits an interrogation signal (s) and tests whether a response unit (2), which is to be carried by an authorized user, responds to the interrogation signal with a response signal (r) that contains as information a code authorized for desecuring a security device (3). If so, the security device is desecured. The securing method shall prevent unauthorized persons from establishing a radio link via relay stations between the interrogation unit (1) and the response unit (2) for providing the authorized code via this radio link without being noticed by the authorized user. The securing method prevents the desecuring of the security device (3) if the signal transit time of a signal transmitted as the interrogation signal (s) and received as the response signal (r) by the interrogation unit (1) during a monitoring time interval (t4–t5) is greater than a prescribed value. The method is carried out in a keyless security system for securing motor vehicles against unauthorized use.

    摘要翻译: 在一种用于保护对象以防止未经授权的使用的方法中,询问单元(1)发送询问信号,并且测试由授权用户承载的响应单元(2)是否响应于询问信号, 响应信号(r),其包含作为授权用于取消安全保护装置(3)的代码的信息。 如果是这样,安全设备就会被弄脏。 安全方法应防止未经授权的人员通过询问单元(1)和响应单元(2)之间的中继站建立无线链路,用于通过该无线电链路提供授权码,而不被授权用户注意到。 如果在监视时间间隔期间由询问单元(1)作为询问信号发送并作为响应信号(r)接收的信号的信号传播时间,则确保方法防止安全装置(3)的去安全 (t 4 -t 5)大于规定值。 该方法在无钥匙安全系统中进行,以保护机动车辆免受未经授权的使用。