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公开(公告)号：US08277829B2
公开(公告)日：2012-10-02
申请号：US12377699
申请日：2007-08-30
申请人： Himanshu Jain , Ana C. Marques , Rui M. Almeida
发明人： Himanshu Jain , Ana C. Marques , Rui M. Almeida
摘要： A biocompatible inorganic porous material having a three-dimensional coexistent network of interconnected macro-pores and nanopores produced by the steps of mixing an organic water-soluble polymer (e.g., polyethylene oxide or a block copolymer of ethylene oxide and propylene oxide), an alkoxysilane, and an inorganic water-soluble calcium salt in an aqueous acid solution, such that a sol-gel process of hydrolysis and polycondensation is initiated and thereby producing a gel; drying the gel to remove solvent by evaporation; and heating the gel to remove the polymer by thermal decomposition, thereby forming an inorganic porous material, which may be suitable for use as a bone tissue scaffold.
摘要翻译： 具有通过混合有机水溶性聚合物（例如，聚环氧乙烷或环氧乙烷和环氧丙烷的嵌段共聚物），烷氧基硅烷等的相互连接的大孔和纳米孔的三维共存网络的生物相容性无机多孔体 和无水水溶性钙盐，在酸性水溶液中开始水解和缩聚的溶胶 - 凝胶法，从而产生凝胶; 干燥凝胶以通过蒸发除去溶剂; 并加热凝胶以通过热分解除去聚合物，从而形成可适合用作骨组织支架的无机多孔材料。
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2.发明申请公开(公告)号：US20100272826A1
公开(公告)日：2010-10-28
申请号：US12377699
申请日：2007-08-30
申请人： Himanshu Jain , Ana C. Marques , Rui M. Almeida
发明人： Himanshu Jain , Ana C. Marques , Rui M. Almeida
摘要： A biocompatible inorganic porous material having a three-dimensional coexistent network of interconnected macro-pores and nanopores produced by the steps of mixing an organic water-soluble polymer (e.g., polyethylene oxide or a block copolymer of ethylene oxide and propylene oxide), an alkoxysilane, and an inorganic water-soluble calcium salt in an aqueous acid solution, such that a sol-gel process of hydrolysis and polycondensation is initiated and thereby producing a gel; drying the gel to remove solvent by evaporation; and heating the gel to remove the polymer by thermal decomposition, thereby forming an inorganic porous material, which may be suitable for use as a bone tissue scaffold.
摘要翻译： 具有通过混合有机水溶性聚合物（例如，聚环氧乙烷或环氧乙烷和环氧丙烷的嵌段共聚物），烷氧基硅烷等的相互连接的大孔和纳米孔的三维共存网络的生物相容性无机多孔体 和无水水溶性钙盐，在酸性水溶液中开始水解和缩聚的溶胶 - 凝胶法，从而产生凝胶; 干燥凝胶以通过蒸发除去溶剂; 并加热凝胶以通过热分解除去聚合物，从而形成可适合用作骨组织支架的无机多孔材料。
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