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公开(公告)号：US08962643B2
公开(公告)日：2015-02-24
申请号：US11678488
申请日：2007-02-23
申请人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
发明人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
IPC分类号： C07D403/12 , A61K31/505 , C07D239/48 , C07D401/12 , C07D409/12 , C07D417/12
CPC分类号： C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20070203162A1
公开(公告)日：2007-08-30
申请号：US11678488
申请日：2007-02-23
申请人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
发明人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20100152218A1
公开(公告)日：2010-06-17
申请号：US12711534
申请日：2010-02-24
申请人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： A61K31/505 , C07D239/48 , A61P35/00 , A61P35/02
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US07915273B2
公开(公告)日：2011-03-29
申请号：US12711534
申请日：2010-02-24
申请人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20070203161A1
公开(公告)日：2007-08-30
申请号：US11678429
申请日：2007-02-23
申请人： Ankush ARGADE , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush ARGADE , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： A61K31/505
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US09593082B2
公开(公告)日：2017-03-14
申请号：US12030069
申请日：2008-02-12
申请人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D413/12 , C07D417/12
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20080221089A1
公开(公告)日：2008-09-11
申请号：US12030069
申请日：2008-02-12
申请人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
发明人： Ankush Argade , Arvinder Sran , David Carroll , Jeffrey Clough , Kin Tso , Somasekhar Bhamidipati , Sambaiah Thota , Rajinder Singh , Vanessa Taylor , Hui Li , Esteban Masuda
IPC分类号： A61K31/5415 , C07D239/48 , A61K31/505 , A61P43/00 , C12N9/99 , C07D279/16
CPC分类号： C07D239/48 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US07601713B2
公开(公告)日：2009-10-13
申请号：US11611568
申请日：2006-12-15
申请人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
发明人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
IPC分类号： A61K31/519 , A61K31/52 , A61K31/517 , C07D498/04 , C07D487/04 , C07D473/16 , A61K31/5355 , A61K31/497 , A61K31/551 , C07D265/36 , C07D413/12 , C07D403/12 , C07D243/08 , A61P19/02 , C07D239/84 , C07D471/04 , C07D401/12
CPC分类号： C07D519/00 , A61K31/517 , C07D239/94 , C07D239/95 , C07D471/04 , C07D473/16 , C07D487/04 , C07D495/04 , C07D495/12
摘要： The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity. The compounds of the present invention are according to structural formula (I): or a salt or N-oxide thereof, wherein B is selected from
摘要翻译： 本公开提供了抑制蛋白激酶（例如JAK，Ax1或Syk激酶）的化合物，包含该化合物的组合物和使用该化合物抑制蛋白激酶并治疗和/或预防与不适当激酶活性相关疾病的方法。 本发明的化合物是根据结构式（I）：或其盐或N-氧化物，其中B选自
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公开(公告)号：US08053434B2
公开(公告)日：2011-11-08
申请号：US12552125
申请日：2009-09-01
申请人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
发明人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
IPC分类号： C07D239/84 , C07D487/14 , C07D413/14 , A61K31/517 , A61K31/519 , A61K31/5355 , A61P35/00 , A61P19/02 , A61P9/10 , A61P17/06 , A61P3/14 , A61P37/08 , A61P1/18
CPC分类号： C07D519/00 , A61K31/517 , C07D239/94 , C07D239/95 , C07D471/04 , C07D473/16 , C07D487/04 , C07D495/04 , C07D495/12
摘要： The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity. The compounds of the present invention are according to structural formula (I): or a salt or N-oxide thereof, wherein B is selected from
摘要翻译： 本公开提供了抑制蛋白激酶（例如JAK，Ax1或Syk激酶）的化合物，包含该化合物的组合物和使用该化合物抑制蛋白激酶并治疗和/或预防与不适当激酶活性相关疾病的方法。 本发明的化合物是根据结构式（I）：或其盐或N-氧化物，其中B选自
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公开(公告)号：US20100069369A1
公开(公告)日：2010-03-18
申请号：US12552125
申请日：2009-09-01
申请人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
发明人： Pingyu Ding , Ankush Argade , Dane Goff , Rajinder Singh , Esteban Masuda , Vanessa Taylor , Sacha Holland
IPC分类号： A61K31/551 , C07D473/00 , A61K31/52 , C07D487/02 , A61K31/519 , C07D239/72 , A61K31/517 , C07D413/14 , A61K31/5377 , C07D265/36 , A61K31/536 , C07D243/08 , A61P43/00
CPC分类号： C07D519/00 , A61K31/517 , C07D239/94 , C07D239/95 , C07D471/04 , C07D473/16 , C07D487/04 , C07D495/04 , C07D495/12
摘要： The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein kinase and treat and/or prevent diseases associated with inappropriate kinase activity. The compounds of the present invention are according to structural formula (I):or a salt or N-oxide thereof, wherein B is selected from
摘要翻译： 本公开提供了抑制蛋白激酶（例如JAK，Ax1或Syk激酶）的化合物，包含该化合物的组合物和使用该化合物抑制蛋白激酶并治疗和/或预防与不适当激酶活性相关疾病的方法。 本发明的化合物是根据结构式（I）：或其盐或N-氧化物，其中B选自
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