公开(公告)号：US20190192597A1

公开(公告)日：2019-06-27

申请号：US15852748

申请日：2017-12-22

Applicant: Industrial Technology Research Institute

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Chu-Hsun LU ,  Shu-Fang WEN ,  Po-Yao HSU ,  Ming-Han LI ,  Kai-An CHUANG ,  Chih-Hsuan CHANG

IPC: A61K36/287 ,  A61K9/00 ,  A61P17/06 ,  A61P17/04

CPC classification number: A61K36/287 ,  A61K9/0014 ,  A61K2236/19 ,  A61K2236/51 ,  A61K2236/53 ,  A61P17/04 ,  A61P17/06

Abstract: The present disclosure provides a method for preparing an extract of Chrysanthemum morifolium with an effect of treating skin diseases, including: (a) performing an extraction procedure on Chrysanthemum morifolium with an extraction solvent to obtain an extract solution; and (b) adding at least one glycoside hydrolases to the extract solution to make an enzyme reaction occur to produce a precipitate, wherein the precipitate is the extract of Chrysanthemum morifolium with an effect of treating skin diseases.

公开(公告)号：US20160008319A1

公开(公告)日：2016-01-14

申请号：US14864203

申请日：2015-09-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Mei-Wei LIN ,  I-Huang LU ,  Hsin-Chieh WU ,  Hsiang-Wen TSENG ,  Ching-Huai KO ,  Chun-Chung WANG ,  Zong-Keng KUO ,  Shyh-Horng LIN ,  Yi-Cheng CHENG ,  Tien-Soung TONG

IPC: A61K31/365 ,  A61K31/7048

CPC classification number: A61K31/365 ,  A61K31/7048 ,  A61K36/14 ,  A61K2300/00

Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

Abstract translation: 本公开提供了用于抑制血管发生的药物组合物，包括有效量的木脂素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了一种抑制血管生成的方法，包括给予有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。

公开(公告)号：US20140170250A1

公开(公告)日：2014-06-19

申请号：US14133213

申请日：2013-12-18

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Mei-Wei LIN ,  I-Huang LU ,  Hsin-Chieh WU ,  Hsiang-Wen TSENG ,  Ching-Huai KO ,  Chun-Chung WANG ,  Zong-Keng KUO ,  Shyh-Horng LIN ,  Yi-Cheng CHENG ,  Tien-Soung TONG

IPC: A61K36/14 ,  A61K31/357

CPC classification number: A61K31/365 ,  A61K31/7048 ,  A61K36/14 ,  A61K2300/00

Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

Abstract translation: 本公开内容提供了用于抑制血管生成的药物组合物，包括有效量的桧属提取物或有效量的木酚素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了抑制血管发生的方法，包括给予有效量的桧属提取物或有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。

公开(公告)号：US20150050315A1

公开(公告)日：2015-02-19

申请号：US14323719

申请日：2014-07-03

Applicant: Industrial Technology Research Institute

Inventor： I-Horng PAN ,  Shu-Fang WEN ,  Ming-Han LI ,  Hsin-Jan YAO ,  Hsin-Chieh WU ,  I-Huang LU ,  Joung-Liang LAN ,  Der-Yuan CHEN ,  Chi-Chien LIN ,  Ching LU

IPC: A61K36/07

CPC classification number: A61K36/07

Abstract: The disclosure provides a method for modulating Th17 cells, including: administering an Antrodia cinnamomea (also named Antrodia camphorata or Taiwanofungus camphoratus) extract to a subject in need thereof, wherein the Antrodia cinnamomea extract has an effect of modulating Th17 cells. The Antrodia cinnamomea extract may include a fruiting body extract of Antrodia cinnamomea or a mycelium extract of Antrodia cinnamomea.

Abstract translation: 本公开内容提供了一种调节Th17细胞的方法，包括：向有需要的受试者施用Antrodia cinnamomea（也称为樟芝或番茄樟脑）提取物，其中所述番茄红素提取物具有调节Th17细胞的作用。 梧桐提取物可以包括樟子松的果实提取物或肉桂樟子的菌丝体提取物。

公开(公告)号：US20140161837A1

公开(公告)日：2014-06-12

申请号：US14101044

申请日：2013-12-09

Applicant: Industrial Technology Research Institute

Inventor： I-Horng PAN ,  I-Haung LU ,  Hsin-Jan YAO ,  Hsin-Chieh WU ,  Chi-Chien LIN

IPC: A61K39/00 ,  C08B37/00

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/55583 ,  A61K2039/57 ,  Y02A50/403

Abstract: The disclosure provides a vaccine adjuvant, including a polysaccharide derived from Antrodia camphorata (also named Antrodia cinnamomea or Taiwanofungus camphoratus) fruiting body, wherein the molecular weight of the polysaccharide is greater than 100 K Da. Furthermore, the polysaccharide is obtained by an extraction process, and the extraction process includes: (a) adding powder of the Antrodia camphorata fruiting body into water to form a mixture; (b) heating the mixture under reflux; (c) after step (b), removing an insoluble matter from the mixture; (d) after step (c), adding ethanol into the mixture to perform a precipitating step and obtain a precipitate; and (e) performing an isolating step to the precipitate to obtain a fraction the molecular weight of which is greater than 100 K Da of the precipitate.

Abstract translation: 本发明提供一种疫苗佐剂，其包括衍生自樟脑（Antrodia cinphorata）（也称为樟芝）的多糖，其中多糖的分子量大于100KDa。 此外，多糖通过提取方法获得，提取方法包括：（a）将樟脑中的樟脑茄子粉末加入水中以形成混合物; （b）在回流下加热混合物; （c）步骤（b）之后，从混合物中除去不溶物; （d）在步骤（c）之后，向混合物中加入乙醇进行沉淀步骤，得到沉淀物; 和（e）对沉淀物进行分离步骤以获得其分子量大于100KDa的沉淀物的级分。