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公开(公告)号：US20180318371A1
公开(公告)日：2018-11-08
申请号：US15772810
申请日：2016-11-03
Applicant: Academia Sinica , Industrial Technology Research Institute
Inventor： Chang-Jen HUANG , Rita P.-Y. CHEN , Yung-Feng LIAO , Bo-Kai WU , Po-Ting CHEN , Hui-Ping TSAI , Yi-Cheng CHENG , Cheng-Li FANG , Hung-Chi CHIEN , Tien-Soung TONG , Ting-Shou CHEN , Shu-Jiau CHIOU
CPC classification number: A61K36/48 , A61K2236/00
Abstract: Disclosed herein is the novel use of use of a Bauhinia spp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or tauopathy, and/or promote neurite outgrowth, thus the Bauhinia spp. extract of the present disclosure may be used as a dietary supplement for the prophylaxis or treatment of amyloid related neurodegenerative diseases so as to ameliorate or alleviate symptoms associated with the amyloid related neurodegenerative diseases.
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公开(公告)号：US20140170250A1
公开(公告)日：2014-06-19
申请号：US14133213
申请日：2013-12-18
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： I-Horng PAN , Hsin-Jan YAO , Mei-Wei LIN , I-Huang LU , Hsin-Chieh WU , Hsiang-Wen TSENG , Ching-Huai KO , Chun-Chung WANG , Zong-Keng KUO , Shyh-Horng LIN , Yi-Cheng CHENG , Tien-Soung TONG
IPC: A61K36/14 , A61K31/357
CPC classification number: A61K31/365 , A61K31/7048 , A61K36/14 , A61K2300/00
Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.
Abstract translation: 本公开内容提供了用于抑制血管生成的药物组合物，包括有效量的桧属提取物或有效量的木酚素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了抑制血管发生的方法，包括给予有效量的桧属提取物或有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。
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公开(公告)号：US20160008319A1
公开(公告)日：2016-01-14
申请号：US14864203
申请日：2015-09-24
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： I-Horng PAN , Hsin-Jan YAO , Mei-Wei LIN , I-Huang LU , Hsin-Chieh WU , Hsiang-Wen TSENG , Ching-Huai KO , Chun-Chung WANG , Zong-Keng KUO , Shyh-Horng LIN , Yi-Cheng CHENG , Tien-Soung TONG
IPC: A61K31/365 , A61K31/7048
CPC classification number: A61K31/365 , A61K31/7048 , A61K36/14 , A61K2300/00
Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.
Abstract translation: 本公开提供了用于抑制血管发生的药物组合物，包括有效量的木脂素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了一种抑制血管生成的方法，包括给予有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。
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公开(公告)号：US20200246410A1
公开(公告)日：2020-08-06
申请号：US16799158
申请日：2020-02-24
Applicant: Academia Sinica , Industrial Technology Research Institute
Inventor： Chang-Jen HUANG , Rita P.-Y. CHEN , Yung-Feng LIAO , Bo-Kai WU , Po-Ting CHEN , Hui-Ping TSAI , Yi-Cheng CHENG , Cheng-Li FANG , Hung-Chi CHIEN , Tien-Soung TONG , Ting-Shou CHEN , Shu-Jiau CHIOU
Abstract: Disclosed herein is the novel use of use of a Bauhinia spp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or tauopathy, and/or promote neurite outgrowth, thus the Bauhinia spp. extract of the present disclosure may be used as a dietary supplement for the prophylaxis or treatment of amyloid related neurodegenerative diseases so as to ameliorate or alleviate symptoms associated with the amyloid related neurodegenerative diseases.
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