公开(公告)号：US20140170250A1

公开(公告)日：2014-06-19

申请号：US14133213

申请日：2013-12-18

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Mei-Wei LIN ,  I-Huang LU ,  Hsin-Chieh WU ,  Hsiang-Wen TSENG ,  Ching-Huai KO ,  Chun-Chung WANG ,  Zong-Keng KUO ,  Shyh-Horng LIN ,  Yi-Cheng CHENG ,  Tien-Soung TONG

IPC: A61K36/14 ,  A61K31/357

CPC classification number: A61K31/365 ,  A61K31/7048 ,  A61K36/14 ,  A61K2300/00

Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

Abstract translation: 本公开内容提供了用于抑制血管生成的药物组合物，包括有效量的桧属提取物或有效量的木酚素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了抑制血管发生的方法，包括给予有效量的桧属提取物或有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。

公开(公告)号：US20210087266A1

公开(公告)日：2021-03-25

申请号：US16948563

申请日：2020-09-23

Applicant: Industrial Technology Research Institute

Inventor： Min-Yuan CHOU ,  Li-Tsen LIN ,  Chung-Yuan SUN ,  Ya-Ping LAI ,  Chin-Pen LAI ,  Ssu-Yuan WU ,  Mei-Wei LIN

IPC: C07K16/28 ,  A61P35/00

Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

公开(公告)号：US20160008319A1

公开(公告)日：2016-01-14

申请号：US14864203

申请日：2015-09-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： I-Horng PAN ,  Hsin-Jan YAO ,  Mei-Wei LIN ,  I-Huang LU ,  Hsin-Chieh WU ,  Hsiang-Wen TSENG ,  Ching-Huai KO ,  Chun-Chung WANG ,  Zong-Keng KUO ,  Shyh-Horng LIN ,  Yi-Cheng CHENG ,  Tien-Soung TONG

IPC: A61K31/365 ,  A61K31/7048

CPC classification number: A61K31/365 ,  A61K31/7048 ,  A61K36/14 ,  A61K2300/00

Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

Abstract translation: 本公开提供了用于抑制血管发生的药物组合物，包括有效量的木脂素作为有效成分。 药物组合物还可以包括药学上可接受的载体或盐。 本公开还提供了一种抑制血管生成的方法，包括给予有效量的木脂素作为有效成分，用于抑制有需要的受试者的血管生成。

公开(公告)号：US20230416362A1

公开(公告)日：2023-12-28

申请号：US18318776

申请日：2023-05-17

Applicant: Industrial Technology Research Institute

Inventor： Min-Yuan CHOU ,  Li-Tsen LIN ,  Chung-Yuan SUN ,  Ya-Ping LAI ,  Chin-Pen LAI ,  Ssu-Yuan WU ,  Mei-Wei LIN

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  A61K45/06

Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

公开(公告)号：US20220228110A1

公开(公告)日：2022-07-21

申请号：US17564729

申请日：2021-12-29

Applicant: Industrial Technology Research Institute

Inventor： Yen-Ju LIN ,  Mei-Wei LIN ,  Min-Yuan CHOU

IPC: C12N5/00 ,  C12N15/85 ,  G01N33/50 ,  C07K14/47

Abstract: A method for screening host cells expressing a target protein is provided. The method includes the following steps: providing an expression vector, the expression vector including a promoter, a gene encoding a target protein and an FTH1 gene; transfecting the host cells with the expression vector; culturing the host cells in a medium; and adding iron ions to the medium, and screening the surviving host cells to obtain the host cells expressing the target protein. An expression vector and a method for establishing a cell line stably expressing an exogenous recombinant gene are also provided.