公开(公告)号：US20150118322A1

公开(公告)日：2015-04-30

申请号：US14514137

申请日：2014-10-14

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Ya-Chin LO ,  Hsiang-Fa LIANG ,  Ming-Cheng WEI ,  Maggie J.M. LU ,  Min-Ying LIN ,  Chih-Peng LIU ,  Chun-MIN LIU ,  Hsiang-Wen TSENG ,  Tse-Min TENG ,  Jui-Hsiang CHEN ,  Yi-Man CHOU ,  Yi-Ting HSIEH ,  Chia-Mu TU

IPC: C08B37/08 ,  A61K33/24 ,  A61K31/4745 ,  A61K31/7036 ,  A61K47/48 ,  A61K31/704

CPC classification number: A61K33/24 ,  A61K31/4172 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/7036 ,  A61K31/704 ,  A61K31/728 ,  A61K45/06 ,  A61K47/542 ,  A61K47/61 ,  A61K47/6921 ,  A61K2300/00

Abstract: The disclosure provides a biomedical composition, including: a hyaluronic acid; a modified histidine; and a polymer or C4-C20 alkane, wherein the modified histidine and the polymer or C4-C20 alkane are grafted to at least one primary hydroxyl group of the hyaluronic acid to allow the hyaluronic acid to form a hyaluronic acid derivative, wherein a graft ratio of the modified histidine is about 1-100%, and a graft ratio of the polymer or C4-C20 alkane is about 0-40%.

Abstract translation: 本公开提供了一种生物医学组合物，其包括：透明质酸; 修饰的组氨酸 和聚合物或C 4 -C 20烷烃，其中将经修饰的组氨酸和聚合物或C 4 -C 20烷烃接枝至透明质酸的至少一个伯羟基，以使透明质酸形成透明质酸衍生物，其中接枝率 的改性组氨酸约为1-100％，聚合物或C4-C20烷烃的接枝率约为0-40％。

公开(公告)号：US20150111834A1

公开(公告)日：2015-04-23

申请号：US14488431

申请日：2014-09-17

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Felice CHENG ,  Maggie J.M. LU ,  Yi-Ju KO ,  Min-Ying LIN ,  Shuen-Hsiang CHOU

IPC: A61K47/42 ,  A61K9/00 ,  A61K47/22 ,  A61K47/36 ,  A61K47/18

CPC classification number: A61K9/0048 ,  A61K9/0024 ,  A61K31/00 ,  A61K47/36

Abstract: The disclosure provides a recipe for in-situ gel, formed by dissolving at least one polymer and at least one gel prevention agent in a polar solvent to form a solution and placing the solution in a condition for in-situ forming gels. The disclosure also provides an implant and a drug delivery system formed by the recipe.

Abstract translation: 本公开提供了通过将至少一种聚合物和至少一种凝胶预防剂溶解在极性溶剂中形成溶液并将溶液置于用于原位形成凝胶的条件下形成的原位凝胶的配方。 本公开还提供了通过该配方形成的植入物和药物递送系统。

公开(公告)号：US20140199369A1

公开(公告)日：2014-07-17

申请号：US13926363

申请日：2013-06-25

Applicant: Industrial Technology Research Institute

Inventor： Maggie J.M. LU ,  Yu-Wen LO ,  Chih-Peng LIU ,  Chia-Wen HUANG ,  Po-Hung LAI ,  Tsan-Lin HU ,  Min-Ying LIN ,  Shuen-Hsiang CHOU ,  Chia-Mu TU

IPC: A61K47/36

CPC classification number: A61K47/36 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/127

Abstract: The disclosure provides a pharmaceutical composition. The pharmaceutical composition includes a chitosan with palmitoyl groups and an active agent. According to another embodiment, the pharmaceutical composition can further include a gelling accelerating agent. According to an embodiment of the disclosure, the active agent of the disclosure can be administered in the form of a nano-drug, liposome, micelle, or microparticle.

Abstract translation: 本公开提供药物组合物。 药物组合物包括具有棕榈酰基团的壳聚糖和活性剂。 根据另一个实施方案，药物组合物可以进一步包括胶凝加速剂。 根据本公开的实施方案，本公开的活性剂可以以纳米药物，脂质体，胶束或微粒的形式施用。