公开(公告)号：US20180142214A1

公开(公告)日：2018-05-24

申请号：US15861625

申请日：2018-01-03

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Min Liu ,  Hsiang-Wen Tseng

IPC: C12N5/09 ,  G01N33/50 ,  C12N5/071

CPC classification number: C12N5/0693 ,  C12N5/067 ,  G01N33/5011 ,  G01N33/5067

Abstract: An in vitro method for screening a testing compound to evaluate its potential as a liver drug of the disclosure is provided. The method includes applying the testing compound to cells of an isolated human liver tumor cell line, named as ITRI-H28, measuring a cell viability of the cells and determining the effect of the testing compound on the cells by calculating a half maximal inhibitory concentration (IC50) of the testing compound.

公开(公告)号：US20150160195A1

公开(公告)日：2015-06-11

申请号：US14513174

申请日：2014-10-13

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Chung Wang ,  Hsiang-Wen Tseng

IPC: G01N33/50 ,  C12N5/071

CPC classification number: G01N33/5067 ,  C12N5/067 ,  C12N5/0693 ,  G01N33/5011

Abstract: An isolated human liver tumor cell line is provided and is named as ITRI-H16, and which was deposited in the Food Industry Research and Development Institute with the accession number BCRC960432 on Nov. 7, 2011. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H16 and treating an interest compound to the ITRI-H16 cell line to determine an effect of the interesting compound on the ITRI-H16 cell line.

Abstract translation: 提供了一种分离的人肝肿瘤细胞系，并命名为ITRI-H16，并于2011年11月7日保藏于食品工业研究开发研究所，登记号为BCRC960432。还提供了一种试剂筛选方法 。 该方法包括提供分离的人肝肿瘤细胞系ITRI-H16并将感兴趣的化合物处理到ITRI-H16细胞系以确定感兴趣的化合物对ITRI-H16细胞系的影响。

公开(公告)号：US20180143181A1

公开(公告)日：2018-05-24

申请号：US15861613

申请日：2018-01-03

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Chung Wang ,  Hsiang-Wen Tseng

IPC: G01N33/50 ,  C12N5/09 ,  C12N5/071

CPC classification number: G01N33/5067 ,  C12N5/067 ,  C12N5/0693 ,  G01N33/5011

Abstract: An in vitro method for screening a testing compound to evaluate its potential as a liver drug is provided. The method includes applying the testing compound to cells of an isolated human liver tumor cell line, named as ITRI-H16, measuring a cell viability of the cells and determining the effect of the testing compound on the cells by calculating a half maximal inhibitory concentration (IC50) of the testing compound.

公开(公告)号：US09682062B2

公开(公告)日：2017-06-20

申请号：US14133213

申请日：2013-12-18

Applicant: Industrial Technology Research Institute

Inventor： I-Horng Pan ,  Hsin-Jan Yao ,  Mei-Wei Lin ,  I-Huang Lu ,  Hsin-Chieh Wu ,  Hsiang-Wen Tseng ,  Ching-Huai Ko ,  Chun-Chung Wang ,  Zong-Keng Kuo ,  Shyh-Horng Lin ,  Yi-Cheng Cheng ,  Tien-Soung Tong

IPC: A61K36/15 ,  A61K36/185 ,  A61K31/365 ,  A61K36/14 ,  A61K31/7048

CPC classification number: A61K31/365 ,  A61K31/7048 ,  A61K36/14 ,  A61K2300/00

Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.

公开(公告)号：US20150159141A1

公开(公告)日：2015-06-11

申请号：US14510136

申请日：2014-10-09

Applicant: Industrial Technology Research Institute

Inventor： Mei-Wei Lin ,  Dian-Kun Li ,  Ling-Mei Wang ,  Ching-Huai Ko ,  Chin-Pen Lai ,  Chun-Min Liu ,  Hsiang-Wen Tseng

IPC: C12N5/09 ,  G01N33/50

CPC classification number: C12N5/0693 ,  C12N5/067 ,  G01N33/5011 ,  G01N33/5067

Abstract: An isolated human liver tumor cell line is provided, which was named as ITRI-H28 and deposited in the Food Industry Research and Development Institute with the accession number BCRC960457 on Dec. 14, 2012. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H28 and adding an interest compound into the ITRI-H28 cell line to determine an effect on the ITRI-H28 cell line.

Abstract translation: 提供了一种分离的人肝肿瘤细胞系，被命名为ITRI-H28，并于2012年12月14日保藏于食品工业研究开发研究所，登记号为BCRC960457。还提供了一种试剂筛选方法。 该方法包括提供分离的人肝肿瘤细胞系ITRI-H28并将兴趣化合物加入到ITRI-H28细胞系中以确定对ITRI-H28细胞系的影响。