公开(公告)号：US20190352276A1

公开(公告)日：2019-11-21

申请号：US16461537

申请日：2017-11-16

Applicant: Joint Stock Company "Biocad"

Inventor： Aleksey Sergeevich Gavrilov ,  Pavel Aleksandrovich Aleshunin ,  Svetlana Leonidovna Gorbunova ,  Mikhail Vladimirovich Rekharsky ,  Natalia Vladimirovna Kozhemyakina ,  Anna Aleksandrovna Kukushkina ,  Anna Sergeevna Kushakova ,  Leonid Evgen`evich Mikhaylov ,  Alexander Moldavsky ,  Aleksandra Vladimirovna Popkova ,  Sergey Aleksandrovich Silonov ,  Svetlana Sergeevna Smirnova ,  Pavel Andreevich Iakovlev

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D471/04

Abstract: The present invention relates to a new compound of formula I: or pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein: V1 is C or N, V2 is C(R2) or N, whereby if V1 is C then V2 is N, if V1 is C then V2 is C(R2), or if V1 is N then V2 is C(R2); each n, k is independently 0, 1; each R2, R11 is independently H, D, Hal, CN, NR′R″, C(O)NR′R″, C1-C6 alkoxy; R3 is H, D, hydroxy, C(O)C1-C6 alkyl, C(O)C2-C6 alkenyl, C(O)C2-C6 alkynyl, C1-C6 alkyl; R4 is H, Hal, CN, CONR′R″, hydroxy, C1-C6 alkyl, C1-C6 alkoxy; L is CH2, NH, O or chemical bond; R1 is selected from the group of the fragments, comprising: Fragment 1, Fragment 2, Fragment 3 each A1, A2, A3, A4 is independently CH, N, CHal; each A5, A6, A7, A8, A9 is independently C, CH or N; R5 is H, CN, Hal, CONR′R″, C1-C6 alkyl, non-substituted or substituted by one or more halogens; each R′ and R″ is independently selected from the group, comprising H, C1-C6 alkyl, C1-C6 cycloalkyl, aryl; R6 is selected from the group: [formula II] each R7, R8, R9, R10 is independently vinyl, methylacetylenyl; Hal is CI, Br, I, F, which have properties of inhibitor of Bruton's tyrosine kinase (Btk), to pharmaceutical compositions containing such compounds, and their use as pharmaceuticals for treatment of diseases and disorder.

公开(公告)号：US12202906B2

公开(公告)日：2025-01-21

申请号：US17288234

申请日：2019-10-30

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Pavel Andreevich Iakovlev ,  Natalia Eugenievna Pestova ,  Arina Vitalevna Anikina ,  Anna Alexandrovna Trudovishnikova ,  Mariia Aleksandrovna Shchemeleva ,  Nina Grachyaevna Kharatian ,  Valery Vladimirovich Solovyev ,  Alexey Konstantinovich Misorin ,  Sergei Vasilyevich Diduk ,  Anna Vladimirovna Eroshova ,  Veronika Sergeevna Usatova ,  Elena Andreevna Krendeleva ,  Iakov Iurevich Ustiugov ,  Aleksei Aleksandrovich Aleksandrov ,  Iana Andreevna Smirnova ,  Svetlana Vladimirovna Koskova ,  Roman Alekseevich Ivanov ,  Dmitry Valentinovich Morozov

IPC: A61K39/395 ,  A61P35/02 ,  C07K16/28 ,  C12N15/63 ,  A61K39/00

Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.

公开(公告)号：US11840531B2

公开(公告)日：2023-12-12

申请号：US17264670

申请日：2019-07-31

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Aleksei Leonidovich Mindich ,  Anna Jur'evna Chestnova ,  Mariia Andreevna Kasatkina ,  Andrei Ivanovich Alafinov ,  Aleksei Sergeevich Gavrilov ,  Anton Aleksandrovich Evdokimov ,  Liliana Vyacheslavovna Lenshmidt ,  Elena Aleksandrovna Maksimenko ,  Mariia Sergeevna Mishina ,  Sergei Aleksandrovich Silonov ,  Evgenii Jur'evich Smirnov ,  Pavel Andreevich Iakovlev ,  Dmitry Valentinovich Morozov

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/4375

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61P35/00

Abstract: The present invention relates to novel compounds of formula I:




which have the properties of CDK8/19 inhibitors, to a pharmaceutical composition comprising said compounds, and to use thereof as a medicine for treating diseases and disorders.

公开(公告)号：US12297269B2

公开(公告)日：2025-05-13

申请号：US17417570

申请日：2019-12-24

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Olga Vladimirovna Britanova ,  Dmitry Borisovich Staroverov ,  Anna Valentinovna Evstrateva ,  Alexey Konstantinovich Misorin ,  Timofey Aleksandrovich Nemankin ,  Mariia Aleksandrovna Shchemeleva ,  Anna Konstantinovna Vladimirova ,  Arina Vitalevna Anikina ,  Roman Alekseevich Ivanov ,  Dmitry Valentinovich Morozov ,  Pavel Andreevich Iakovlev ,  Sergey Anatolievich Lukyanov

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06

Abstract: A monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. A nucleic acid encoding the antibody or antigen-binding fragment thereof, an expression vector, a method for preparing the antibody, and use of the antibody in treatment of diseases or disorders associated with the human T cell receptor family. The generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

公开(公告)号：US11236167B2

公开(公告)日：2022-02-01

申请号：US16605865

申请日：2018-04-11

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Andrei Borisovich Ulitin ,  Viktoriia Mikhailovna Ekimova ,  Ekaterina Vladimirovna Sofronova ,  Yulia Sergeevna Chernykh ,  Sergei Andreevich Ageev ,  Anna Konstantinovna Vladimirova ,  Aleksei Aleksandrovich Aleksandrov ,  Pavel Alekseevich Grebnev ,  Valery Vladimirovich Solovyev ,  Iakov Iurevich Ustiugov ,  Pavel Andreevich Iakovlev ,  Timofey Aleksandrovich Nemankin ,  Dmitry Valentinovich Morozov

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.

公开(公告)号：US12227572B2

公开(公告)日：2025-02-18

申请号：US17417686

申请日：2020-02-20

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Olga Vladimirovna Britanova ,  Dmitry Borisovich Staroverov ,  Anna Valentinovna Evstrateva ,  Alexey Konstantinovich Misorin ,  Timofey Aleksandrovich Nemankin ,  Mariia Aleksandrovna Shchemeleva ,  Anna Konstantinovna Vladimirova ,  Arina Vitalevna Anikina ,  Roman Alekseevich Ivanov ,  Dmitry Valentinovich Morozov ,  Pavel Andreevich Iakovlev ,  Sergey Anatolievich Lukyanov

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.

公开(公告)号：US12173075B2

公开(公告)日：2024-12-24

申请号：US16753488

申请日：2018-10-02

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Ekaterina Vladimirovna Sofronova ,  Aleksei Konstantinovich Misorin ,  Aleksandr Nikolaevich Doronin ,  Timofey Aleksandrovich Nemankin ,  Aleksandra Aleksandrovna Sozonova ,  Galina Stepanovna Zhirivskaia ,  Sergey Aleksandrovich Legotsky ,  Anna Konstantinovna Vladimirova ,  Alina Valerevna Beliasnikova ,  Mariia Aleksandrovna Shchemeleva ,  Pavel Andreevich Iakovlev ,  Valery Vladimirovich Solovyev ,  Elena Andreevna Krendeleva ,  Natalia Evgenevna Pestova ,  Dmitry Valentinovich Morozov

IPC: C12N15/64 ,  C07K16/28 ,  A61K39/00 ,  A61K45/06

Abstract: The present disclosure relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The disclosure also relates to DNA encoding the antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using the antibodies.

公开(公告)号：US11453717B2

公开(公告)日：2022-09-27

申请号：US16097562

申请日：2016-12-02

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Dmitry Valentinovich Morozov ,  Andrei Borisovich Ulitin ,  Ekaterina Sergeevna Zubareva ,  Iakov Iurevich Ustiugov ,  Aleksandr Vladimirovich Karabelskii ,  Dmitry Valeryevich Korzhavin ,  Tatiana Veniaminovna Chernovskaya ,  Aleksandr Valerevich Grachev ,  Yury Ivanovich Basovskiy ,  Ekaterina Aleksandrovna Lomkova ,  Veronika Sergeevna Usatova ,  Aleksei Aleksandrovich Aleksandrov ,  Elena Leonidovna Morozova ,  Roman Alekseevich Ivanov ,  Pavel Andreevich Iakovlev

IPC: C07K16/24 ,  A61K39/395 ,  A61P19/02 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.