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    Blunt rolling method and devices
    2.
    发明授权
    Blunt rolling method and devices 有权

    公开(公告)号：US10905152B2

    公开(公告)日：2021-02-02

    申请号：US15940614

    申请日：2018-03-29

    Applicant: Jason Kang ,  Daniel Chu

    Inventor： Jason Kang ,  Daniel Chu

    IPC: A24C3/00 ,  A24C1/04 ,  A24C5/10 ,  A24F9/02 ,  A24C5/46 ,  A24C5/54 ,  A24F25/02 ,  A24C5/34

    Abstract: The embodiments disclose a method including creating a blunt rolling device for rolling blunt smoking products, rolling a wrapper on a wrapper roller tube to create a blunt wrapper tube with a glass tip, tamping smoking material into the blunt wrapper tube at a user defined density, twisting, cutting and tucking wrapper excess into the glass tip, and controlling the operations of the blunt rolling device using a computer, wireless communications and a blunt rolling method and device program for sequencing processes, operating solenoid drive motors and humidity and temperature devices of a smoking material humidor, adjusting settings of devices using predetermined data stored in digital memory devices and accessed using digital processors.

    BLUNT ROLLING METHOD AND DEVICES
    4.
    发明申请
    BLUNT ROLLING METHOD AND DEVICES 审中-公开

    公开(公告)号：US20190297936A1

    公开(公告)日：2019-10-03

    申请号：US15940614

    申请日：2018-03-29

    Applicant: Jason Kang ,  Daniel Chu

    Inventor： Jason Kang ,  Daniel Chu

    IPC: A24C3/00 ,  A24C1/04 ,  A24C5/10 ,  A24C5/34 ,  A24C5/46 ,  A24C5/54 ,  A24F25/02 ,  A24F9/02

    Abstract: The embodiments disclose a method including creating a blunt rolling device for rolling blunt smoking products, rolling a wrapper on a wrapper roller tube to create a blunt wrapper tube with a glass tip, tamping smoking material into the blunt wrapper tube at a user defined density, twisting, cutting and tucking wrapper excess into the glass tip, and controlling the operations of the blunt rolling device using a computer, wireless communications and a blunt rolling method and device program for sequencing processes, operating solenoid drive motors and humidity and temperature devices of a smoking material humidor, adjusting settings of devices using predetermined data stored in digital memory devices and accessed using digital processors.

    ROSIN CORE ROLLED SMOKING PRODUCT METHOD AND DEVICES
    5.
    发明申请
    ROSIN CORE ROLLED SMOKING PRODUCT METHOD AND DEVICES 有权

    公开(公告)号：US20220264934A1

    公开(公告)日：2022-08-25

    申请号：US17179809

    申请日：2021-02-19

    Applicant: JASON KANG ,  Daniel Chu

    Inventor： JASON KANG ,  Daniel Chu

    IPC: A24D1/00 ,  A24C5/10 ,  A24C5/47 ,  A24D1/18

    Abstract: The embodiments disclose an apparatus for producing rosin core rolled smoking products, including a modular rosin core rolled smoking product apparatus assembly for automatically producing at least one rosin core rolled smoking product, at least one interchangeable packing and shaping subassembly for automatically packing and shaping user selected smoking materials, at least one interchangeable injection subassembly for automatically injecting a user selected rosin core material between two layers of smoking materials, at least one interchangeable insertion subassembly for inserting at least one tip coupled to the rosin core rolled smoking product, at least one paper wrapper application roller for rolling and adhering a paper wrapper around the at least one rosin core rolled smoking product, and a rosin core rolling apparatus app for remotely regulating the modular rosin core rolled smoking product apparatus assembly functions and operations.

    Processes of synthesizing dihydropyridophthalazinone derivatives
    6.
    发明授权
    Processes of synthesizing dihydropyridophthalazinone derivatives 有权
    合成二氢吡啶并酞嗪酮衍生物的方法

    公开(公告)号：US08765945B2

    公开(公告)日：2014-07-01

    申请号：US13023140

    申请日：2011-02-08

    Applicant: Bing Wang ,  Daniel Chu ,  Yongbo Liu ,  Quan Jiang ,  Lei Lu

    Inventor： Bing Wang ,  Daniel Chu ,  Yongbo Liu ,  Quan Jiang ,  Lei Lu

    IPC: C07D237/36

    CPC classification number: C07D405/06 ,  C07D249/08 ,  C07D401/04 ,  C07D403/06 ,  C07D471/06

    Abstract: Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.

    Abstract translation: 本文提供了合成二氢吡啶并二氮杂萘酮衍生物的方法，例如5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基） 9-二氢-2H-吡啶并[4,3,2-de]酞嗪-3（7H） - 酮及其立体异构体，它们是有效的聚（ADP-核糖）聚合酶（PARP）抑制剂以及新的合成中间体化合物。

    Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt
    7.
    发明授权
    Crystalline (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt 有权
    结晶（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶 [4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐

    公开(公告)号：US08735392B2

    公开(公告)日：2014-05-27

    申请号：US13277607

    申请日：2011-10-20

    Applicant: Bing Wang ,  Daniel Chu ,  Yongbo Liu ,  Shichun Peng

    Inventor： Bing Wang ,  Daniel Chu ,  Yongbo Liu ,  Shichun Peng

    IPC: A01N43/58 ,  A61K31/495

    CPC classification number: C07D471/06

    Abstract: Provided herein are (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt are also provided, as are methods of using (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate salt to treat a disease or condition, such as a cancer.

    Abstract translation: 本文提供的是（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H- - 吡啶并[4,3,2-de]酞嗪-3（7H） - 酮甲磺酸盐形式，包括晶型，及其制备方法。 包含（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢 - 还提供了使用（8S，9R）-5-氟-8-（4-氟苯基）-9（7H） - 酮的方法，使用2-吡啶并[4,3,2- - （1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶并[4,3,2-de]酞嗪-3（7H） - 酮甲苯磺酸盐 治疗疾病或病症，如癌症。

    CELL COUNTING SYSTEMS AND METHODS
    8.
    发明申请
    CELL COUNTING SYSTEMS AND METHODS 有权
    细胞计数系统和方法

    公开(公告)号：US20120314092A1

    公开(公告)日：2012-12-13

    申请号：US13483771

    申请日：2012-05-30

    Applicant: Daniel Chu ,  Eli A. Hefner ,  Yann Jouvenot

    Inventor： Daniel Chu ,  Eli A. Hefner ,  Yann Jouvenot

    IPC: H04N5/225 ,  B01L3/00

    CPC classification number: G01N15/1463 ,  G01N2015/1006

    Abstract: An automated system captures multiple digital images of a sample, from different viewing areas of the sample. The images are analyzed and a test result may be reported based on the count of cells in all of the digital images. The system may be especially applicable to the testing of samples having low cell concentrations, as the variability between tests may be reduced as compared with a system that bases its test results on only a single image of the sample. The system may count the cells in a first digital image of the sample, and may capture or analyze one or more additional digital images only when it is recognized that additional measurements are needed to ensure adequate accuracy and repeatability of the test.

    Abstract translation: 自动化系统从样品的不同观察区域捕获样品的多个数字图像。 分析图像，并且可以基于所有数字图像中的单元的计数来报告测试结果。 该系统可能特别适用于具有低细胞浓度的样品的测试，因为与将其测试结果仅基于样品的单个图​​像的系统相比，可以减少测试之间的可变性。 系统可以对样本的第一数字图像中的单元进行计数，并且可以仅在认识到需要额外的测量以确保测试的足够的精度和可重复性时才捕获或分析一个或多个附加的数字图像。

    SEMI-SYNTHETIC GLYCOPEPTIDES HAVING ANTIBACTERIAL ACTIVITY
    10.
    发明申请
    SEMI-SYNTHETIC GLYCOPEPTIDES HAVING ANTIBACTERIAL ACTIVITY 审中-公开
    具有抗菌活性的半合成糖蛋白

    公开(公告)号：US20100216699A1

    公开(公告)日：2010-08-26

    申请号：US12697967

    申请日：2010-02-01

    Applicant: Daniel Chu ,  Tao Ye

    Inventor： Daniel Chu ,  Tao Ye

    IPC: A61K38/14 ,  C07K9/00 ,  C07K7/64 ,  A61K38/12 ,  A61P31/04

    CPC classification number: C07K9/008 ,  A61K38/00 ,  C07K7/06

    Abstract: Semi-synthetic glycopeptides having antibacterial activity are described. Also described are processes of preparing such semi-synthetic glycopeptides by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in mild acidic medium to give the amino acid-4 monosaccharide; protection of the amino groups in the molecule; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also included are the process of conversion of the amide group in amino acid-3 on these scaffolds to various acylureas, acylamide, acylsulfonamide, acylsulfonylurea derivatives and aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction procedures. Further provided herein are pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, including bacterial infections.

    Abstract translation: 描述了具有抗菌活性的半合成糖肽。 还描述了通过糖肽（化合物A，化合物B，化合物H或化合物C）的化学修饰或通过水解母体糖肽的氨基酸-4的二糖部分制备的单糖制备这种半合成糖肽的方法 温和酸性培养基，得到氨基酸-4单糖; 保护分子中的氨基; 并将这些支架的大环上的酸部分转化为某些取代的酰胺。 还包括在氨基酸-7上通过曼尼希反应方法将这些支架上的氨基酸3中的酰胺基团转化为各种酰基脲，酰基酰胺，酰基磺酰胺，酰基磺酰脲衍生物和氨基甲基化，其中氨基酸-7的取代基含有磺酰胺或酰基磺酰胺基团。 本文进一步提供含有该化合物的药物组合物，以及该化合物用于治疗和/或预防疾病包括细菌感染的方法。

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