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    Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
    9.
    发明授权
    Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt 失效
    治疗或预防骨质疏松症的方法包括向有需要的患者施用有效量的包含苯甲脒衍生物或其盐的药物组合物，以及阿仑膦酸或其盐

    公开(公告)号：US07964584B2

    公开(公告)日：2011-06-21

    申请号：US12533537

    申请日：2009-07-31

    申请人： Jei Man Ryu ,  Jin Soo Lee ,  Jae Hoon Park ,  Yun-Ha Hwang ,  Duk Kyun Chung

    发明人： Jei Man Ryu ,  Jin Soo Lee ,  Jae Hoon Park ,  Yun-Ha Hwang ,  Duk Kyun Chung

    IPC分类号： A61K31/66 ,  A61K31/425

    CPC分类号： A61K31/426 ,  A61K31/663 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof.As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.

    摘要翻译： 本发明涉及用于预防和治疗骨质疏松症的药物组合物，其包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} 苄脒，4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒或其盐，和阿仑膦酸或其盐。 作为骨质疏松症的预防或治疗组合物，将N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的组合处理， 4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其盐和阿仑膦酸或其盐对破骨细胞表现出优异的抑制作用 与每个单独的治疗相比，可以用于预防或治疗骨质疏松症。