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    Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
    2.
    发明授权
    Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt 失效
    治疗或预防骨质疏松症的方法包括向有需要的患者施用有效量的包含苯甲脒衍生物或其盐的药物组合物，以及阿仑膦酸或其盐

    公开(公告)号：US07964584B2

    公开(公告)日：2011-06-21

    申请号：US12533537

    申请日：2009-07-31

    申请人： Jei Man Ryu ,  Jin Soo Lee ,  Jae Hoon Park ,  Yun-Ha Hwang ,  Duk Kyun Chung

    发明人： Jei Man Ryu ,  Jin Soo Lee ,  Jae Hoon Park ,  Yun-Ha Hwang ,  Duk Kyun Chung

    IPC分类号： A61K31/66 ,  A61K31/425

    CPC分类号： A61K31/426 ,  A61K31/663 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof.As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.

    摘要翻译： 本发明涉及用于预防和治疗骨质疏松症的药物组合物，其包含N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} 苄脒，4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒或其盐，和阿仑膦酸或其盐。 作为骨质疏松症的预防或治疗组合物，将N-羟基-4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基}苄脒的组合处理， 4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其盐和阿仑膦酸或其盐对破骨细胞表现出优异的抑制作用 与每个单独的治疗相比，可以用于预防或治疗骨质疏松症。

    NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL PREPARATION INCLUDING SAME
    7.
    发明申请
    NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL PREPARATION INCLUDING SAME 审中-公开
    新的2,6-取代-3-硝基吡啶衍生物，其制备方法和包括其的药物制备

    公开(公告)号：US20110306641A1

    公开(公告)日：2011-12-15

    申请号：US13133649

    申请日：2009-12-04

    申请人： Jei Man Ryu ,  Jin Soo Lee ,  Whui Jung Park ,  Yun Ha Hwang ,  Ki_Yoon Kim

    发明人： Jei Man Ryu ,  Jin Soo Lee ,  Whui Jung Park ,  Yun Ha Hwang ,  Ki_Yoon Kim

    IPC分类号： A61K31/4439 ,  A61P19/10 ,  C07D401/14

    CPC分类号： C07D213/74 ,  A61K31/4439 ,  C07D401/14

    摘要： The present invention relates to a novel 2,6-substituted-3-nitropyridine derivative compound, a method for preparing same, a pharmaceutical composition for prevention and treatment of osteoporosis including same, applications of same for preparing the therapeutic agent of osteoporosis prevention and treatment, and a method for prevention and treatment of osteoporosis using same. The 2,6-substituted-3-nitropyridine derivative compound of the present invention effectively increases osteoblast activity and also inhibits the formation of osteoclasts, so that it may be usefully used for the prevention and treatment of osteoporosis.

    摘要翻译： 本发明涉及一种新的2,6-取代-3-硝基吡啶衍生物化合物，其制备方法，用于预防和治疗包括其的骨质疏松症的药物组合物，其用于制备预防和治疗骨质疏松症的治疗剂的应用 以及使用其预防和治疗骨质疏松症的方法。 本发明的2,6-取代-3-硝基吡啶衍生物化合物有效地增加成骨细胞活性，并且还抑制破骨细胞的形成，从而可有效地用于预防和治疗骨质疏松症。