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    Pyrrolo[1,2b]pyridazine compounds and their uses
    3.
    发明申请
    Pyrrolo[1,2b]pyridazine compounds and their uses 审中-公开
    吡咯并[1,2b]哒嗪化合物及其用途

    公开(公告)号：US20070224636A1

    公开(公告)日：2007-09-27

    申请号：US11388418

    申请日：2006-03-24

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: G01N33/53 ,  A61K31/502

    CPC classification number: G01N33/948 ,  A61K31/502 ,  G01N2500/02 ,  G01N2800/301

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Abstract translation: 公开了新的CRF受体拮抗剂及其用于治疗多种疾病的用途，包括表现出CRF过度分泌或与CRF或CRF受体如焦虑和抑郁症相关的疾病。 本发明的CRF受体拮抗剂具有式（I）的结构：包括立体异构体或立体异构体的混合物，药学上可接受的前药或其药学上可接受的盐，其中在式（I）中R是H或Me。

    Pyrrolo[1,2b]pyridazine compounds and their uses
    4.
    发明申请
    Pyrrolo[1,2b]pyridazine compounds and their uses 审中-公开
    吡咯并[1,2b]哒嗪化合物及其用途

    公开(公告)号：US20060148807A1

    公开(公告)日：2006-07-06

    申请号：US11378537

    申请日：2006-03-17

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: A61K31/503 ,  G01N33/53

    CPC classification number: A61K31/503 ,  G01N33/566 ,  G01N2500/00

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Abstract translation: 公开了新的CRF受体拮抗剂及其用于治疗多种疾病的用途，包括表现出CRF过度分泌或与CRF或CRF受体如焦虑和抑郁症相关的疾病。 本发明的CRF受体拮抗剂具有式（I）的结构：包括立体异构体或立体异构体的混合物，药学上可接受的前药或其药学上可接受的盐，其中在式（I）中R是H或Me。

    Pyrrolo[1,2-B]pyridazine compounds and their uses
    6.
    发明授权
    Pyrrolo[1,2-B]pyridazine compounds and their uses 失效
    吡咯并[1,2-B]哒嗪化合物及其用途

    公开(公告)号：US07034023B2

    公开(公告)日：2006-04-25

    申请号：US10799404

    申请日：2004-03-12

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: C07D487/04 ,  A61K31/5025 ,  A61P25/22 ,  A61P25/24

    CPC classification number: C07D487/04

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

    Abstract translation: 公开了新的CRF受体拮抗剂及其用于治疗多种疾病的用途，包括表现出CRF过度分泌或与CRF或CRF受体如焦虑和抑郁症相关的疾病。 本发明的CRF受体拮抗剂具有式（I）的结构：包括立体异构体或立体异构体的混合物，药学上可接受的前药或其药学上可接受的盐，其中在式（I）中R是H或Me。

    Troponyl piperazines as dopamine D4 receptor ligands
    9.
    发明授权
    Troponyl piperazines as dopamine D4 receptor ligands 失效
    托膦酰基哌嗪作为多巴胺D4受体配体

    公开(公告)号：US5998414A

    公开(公告)日：1999-12-07

    申请号：US907672

    申请日：1997-08-08

    Applicant: Xin Wang ,  Jian-min Fu ,  Adi M. Treasurywala

    Inventor： Xin Wang ,  Jian-min Fu ,  Adi M. Treasurywala

    IPC: C07D243/38 ,  C07D295/116 ,  C07D317/58 ,  C07D409/12 ,  A61K31/495 ,  C07D295/155 ,  C07D405/06

    CPC classification number: C07D295/116 ,  C07D243/38 ,  C07D317/58 ,  C07D409/12

    Abstract: Described herein are compounds of the general formula: ##STR1## a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, wherein:R.sub.1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C.sub.1-4 alkyl, C.sub.1-4 -alkoxy, nitro, trifluoromethyl, trifluoromethoxy or cyano;R.sub.2 is C.sub.4-9 alkyl; phenyl or phenyl substituted with one or two groups selected independently from OH, cyano, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, trifluoromethyl, trifluoromethoxy, nitro or phenyl; naphthyl;phenyl fused to a 5 or 6-membered heterocycle; the coumarin moiety ##STR2## wherein R.sub.3 and R.sub.4 are selected independently from H, C.sub.1-4 alkyl and C.sub.1-4 alkoxy;or 1,2-methylenedioxy phenyl;with the proviso that R.sub.2 is not phenyl or 3,4-dimethoxyphenyl when R.sub.1 is H.Also described is their use as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia and anxiety.

    Abstract translation: 本文描述的是下列通式的化合物：其立体异构体，溶剂化物或其药学上可接受的盐，其中：R 1是被一个或两个独立地选自卤素，C 1-4烷基，C 1-4 - 烷氧基，硝基，三氟甲基，三氟甲氧基或氰基; R2是C4-9烷基; 苯基或被一个或两个独立地选自OH，氰基，卤素，C 1-4烷氧基，C 1-4烷基，三氟甲基，三氟甲氧基，硝基或苯基的基取代的苯基; 萘基; 与5或6元杂环稠合的苯基; 香豆素部分，其中R 3和R 4独立地选自H，C 1-4烷基和C 1-4烷氧基; 或1,2-亚甲二氧基苯基; 条件是当R 1为H时，R 2不是苯基或3,4-二甲氧基苯基。还描述了它们作为药物治疗其中涉及D4受体的适应症的用途，例如精神分裂症和焦虑症。

    Pyrrolo[1,2-B]pyridazine compounds and their uses
    10.
    发明申请
    Pyrrolo[1,2-B]pyridazine compounds and their uses 审中-公开

    公开(公告)号：US20060166998A1

    公开(公告)日：2006-07-27

    申请号：US11386385

    申请日：2006-03-22

    Applicant: Jian-min Fu

    Inventor： Jian-min Fu

    IPC: G01N33/53 ,  A61K31/502

    CPC classification number: A61K31/502 ,  G01N33/566 ,  G01N2500/00

    Abstract: Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I): including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

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