公开(公告)号：US06723337B1

公开(公告)日：2004-04-20

申请号：US09509303

申请日：2000-06-19

申请人： Jin Deog Song ,  Chul Min Park ,  Young Kwon Choi ,  Heon Han Lee ,  Yong Ho Shim ,  Hye Jeong Yoon

发明人： Jin Deog Song ,  Chul Min Park ,  Young Kwon Choi ,  Heon Han Lee ,  Yong Ho Shim ,  Hye Jeong Yoon

IPC分类号： A61F1302

CPC分类号： A61K9/703 ,  A61K9/7061 ,  A61K31/196 ,  Y10S514/946 ,  Y10S514/947 ,  Y10S514/964

摘要： The invention herein relates to a transdermal drug delivery systern for anti-Inflammatory analgesic. agent comprising diclofenac diethylammonium salt, wherein a backing film (1), a matrix layer (2) containing active ingredients, a release liner (3) which is removed before application onto the skin are laminated therein. Mome particularly, the invention herein relates to a transdermal drug delivery system for anti-inflammatory analgesic agent comprising diclofenac diethylammonum salt, wherein the transdermal penetration and adhesion of the patch to the body are enhanced by means of a matrix layer which comprises a diclofenac diethylammonum salt as active ingredient in addition to acrylic polymer as adhesive constituent, non-ionic surfacant as absorption enhancer, terpene and dissolution assistant, and the volatile and non-volatile constituents of the composition arc separately applied therein for significantly reducing the manufacturing time thereof.

摘要翻译： 本发明涉及用于抗炎镇痛剂的透皮药物递送系统。 包含双氯芬酸二乙基铵盐的药剂，其中背衬膜（1），含有活性成分的基质层（2），在施用于皮肤之前被去除的剥离衬垫（3）。 特别地，本发明涉及用于消炎止痛剂的透皮药物递送系统，其包括双氯芬酸二乙基铵盐，其中通过包含双氯芬酸二乙基铵盐的基质层增强贴片对身体的透皮渗透和粘附 作为除了作为粘合剂成分的丙烯酸类聚合物之外的活性成分，作为吸收促进剂的非离子表面活性剂，萜烯和溶解助剂以及组合物的挥发性和非挥发性组分分别施加在其中，以显着减少其制造时间。

公开(公告)号：US5741511A

公开(公告)日：1998-04-21

申请号：US627805

申请日：1996-04-10

申请人： Hun Han Lee ,  Joong Woong Cho ,  Choul Young Kim ,  Chaul Min Pai ,  Jin Deog Song ,  Chul Min Park ,  Hye Jeong Yoon ,  Yoon Yeo ,  Jae Seung Paick

发明人： Hun Han Lee ,  Joong Woong Cho ,  Choul Young Kim ,  Chaul Min Pai ,  Jin Deog Song ,  Chul Min Park ,  Hye Jeong Yoon ,  Yoon Yeo ,  Jae Seung Paick

IPC分类号： A61M37/00 ,  A61F5/41 ,  A61F6/04 ,  A61K9/00 ,  A61K9/70 ,  A61F13/00 ,  A61F6/02

CPC分类号： A61K9/703 ,  A61F5/41 ,  A61F6/04 ,  A61K9/0034 ,  A61K9/7092 ,  Y10S602/901

摘要： The present invention is to provide a method and a transdermal drug delivery device for treating erectile dysfunction which comprises a patch containing pharmaceutically active ingredient and being directly apply to the male glans penis and its support and the rings for constricting the base part of the penis to aid the erection. The patch according to the present invention may be divided into two types, i.e. a cylinder type patch and a multi-reservoir type patch. The transdermal drug delivery patch device of the present invention is painless and safely to use and may be effectively produced and maintained erection of the penis without the adverse side effects and with a high degree of patient acceptability in the case of male impotence.

摘要翻译： 本发明提供一种用于治疗勃起功能障碍的方法和透皮药物递送装置，其包含含有药物活性成分的补片，并且直接应用于雄性龟头阴茎及其支撑体和用于收缩阴茎基部的环 帮助勃起。 根据本发明的贴片可以分为两种类型，即圆柱型贴片和多储器型贴片。 本发明的透皮药物递送贴片装置是无痛且安全使用的，并且可以有效地产生和维持阴茎的勃起而没有不利的副作用，并且在男性阳the的情况下具有高度的患者可接受性。

公开(公告)号：US08324246B2

公开(公告)日：2012-12-04

申请号：US12393528

申请日：2009-02-26

申请人： Churlmin Seong ,  Chul Min Park ,  Soyoung Kim ,  Wookyu Park ,  Nosang Park

发明人： Churlmin Seong ,  Chul Min Park ,  Soyoung Kim ,  Wookyu Park ,  Nosang Park

IPC分类号： A01N43/40 ,  A61K31/445 ,  C07D211/30 ,  C07D233/00

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D403/12

摘要： Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

摘要翻译： 本文公开了一种新的吲哚羧酸双吡啶羧酰胺衍生物及其制备方法，以及用于预防或治疗肥胖，尿失调和CNS障碍的组合物，其含有活性成分。 因为根据本发明的吲哚羧酸双吡啶甲酰胺衍生物对5-HT 2C受体具有高亲和力，因此选择性地对5-HT 2C受体起作用，所以衍生物很少具有由其它受体引起的不良作用。 由于衍生物有效抑制5-羟色胺活性，因此可用于治疗或预防肥胖症; 尿失禁如尿失禁，早泄，勃起功能障碍和前列腺增生; 与5-HT2c受体相关的诸如抑郁症，焦虑症，忧虑症，惊恐障碍，癫痫症，强迫症，偏头痛，睡眠障碍，药物滥用戒断，阿尔茨海默病和精神分裂症等CNS疾病。

公开(公告)号：US20100035866A1

公开(公告)日：2010-02-11

申请号：US12293965

申请日：2006-03-28

申请人： Churlmin Seong ,  Jinil Choi ,  Chul Min Park ,  Wookyu Park ,  Jaeyang Kong ,  Sunhee Kang ,  Chimin Park

发明人： Churlmin Seong ,  Jinil Choi ,  Chul Min Park ,  Wookyu Park ,  Jaeyang Kong ,  Sunhee Kang ,  Chimin Park

IPC分类号： A61K31/5415 ,  C07D285/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/24 ,  A61P25/22 ,  A61P25/32

CPC分类号： C07D285/24

摘要： The present invention relates to compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones according to the present invention have excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors. Also, the compounds reverse a disruption of PPI by apomorphine and don't show rotatod deficit in mice. Therefore the compounds according to the present invention may be valuably used for treatment of a 5HT6 receptor relating disorders.

摘要翻译： 本发明涉及作为5HT6受体拮抗剂的取代-1,1-二氧代 - 苯并[1,2,4]噻二嗪-3-酮的化合物，其制备方法和含有该化合物的药物组合物，其用于治疗 中枢神经系统疾病。 根据本发明的取代的-1,1-二氧代 - 苯并[1,2,4]噻二嗪-3-酮的化合物对5HT6受体具有优异的结合亲和力，对其它受体的5HT6受体的选择性优异。 此外，化合物反转了阿朴吗啡对PPI的破坏，并且在小鼠中不显示旋转异位缺陷。 因此，根据本发明的化合物可以有价值地用于治疗5HT6受体相关疾病。

公开(公告)号：US06564164B1

公开(公告)日：2003-05-13

申请号：US09691653

申请日：2000-10-18

申请人： Jeong Guon Ih ,  Chul Min Park

发明人： Jeong Guon Ih ,  Chul Min Park

IPC分类号： G06F1500

CPC分类号： G01K11/22

摘要： A method for optimally determining sensor positions for an acoustic pyrometry, capable of obtaining a minimum number of sensors satisfying a given error limit and determining positions of the obtained number of sensors for error minimization, in which a predetermined number of sensors are arbitrarily arranged on sides of a rectangular sectional area to be measured and a transfer matrix is calculated with respect to positions of all the sensors, with effective independence values obtained for respective paths of each of the sensors by performing singular value decomposition with respect to the calculated transfer matrix and a total effective independence value of each of the sensors is obtained by summing up the effective independence values obtained for the respective paths, followed by having a smallest one of the obtained total effective independence valves removed from among the sensors and the above steps are repeated until the number of the remaining sensors becomes equal to a target valve.

摘要翻译： 一种用于最佳地确定用于声学高温计的传感器位置的方法，其能够获得满足给定误差极限的最小数量的传感器，并且确定所获得的用于误差最小化的传感器数量的位置，其中预定数量的传感器被任意布置在侧面 对于要测量的矩形截面积，并且相对于所有传感器的位置计算传递矩阵，通过对于所计算的传递矩阵执行奇异值分解，获得针对每个传感器的相应路径的有效独立性值，以及 每个传感器的总有效独立性值通过对各个路径获得的有效独立性值进行求和，然后将获得的从传感器中去除的总有效独立阀中的最小一个重复直到 剩余传感器的数量等于焦油 得到阀门。

公开(公告)号：US07915109B2

公开(公告)日：2011-03-29

申请号：US11957575

申请日：2007-12-17

申请人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

发明人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

IPC分类号： H01L21/336 ,  H01L21/8234

CPC分类号： H01L29/0847 ,  H01L29/66636 ,  H01L29/66659 ,  H01L29/78

摘要： A method of manufacturing a probe includes: forming a first slant face of the probe through an anisotropic etching process using a first etching mask pattern formed on a silicon substrate; forming a first semiconductor electrode region; forming a second etching mask pattern in an opposite direction of the first etching mask pattern on the silicon substrate; forming a spacer layer on a side wall of the second etching mask pattern; forming a second slant face of the probe; forming a second semiconductor electrode region; forming a silicon oxide layer pattern on the resulting silicon substrate; forming spacer layers on both side walls of the silicon oxide layer pattern; and etching the silicon substrate to a predetermined depth.

摘要翻译： 探针的制造方法包括：使用形成在硅衬底上的第一蚀刻掩模图案，通过各向异性蚀刻工艺形成探针的第一倾斜面; 形成第一半导体电极区域; 在所述硅衬底上与所述第一蚀刻掩模图案的相反方向形成第二蚀刻掩模图案; 在所述第二蚀刻掩模图案的侧壁上形成间隔层; 形成探针的第二倾斜面; 形成第二半导体电极区域; 在所得硅衬底上形成氧化硅层图案; 在氧化硅层图案的两个侧壁上形成间隔层; 并将硅衬底蚀刻到预定深度。

公开(公告)号：US07700393B2

公开(公告)日：2010-04-20

申请号：US12043982

申请日：2008-03-07

申请人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

发明人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

IPC分类号： H01L21/00

CPC分类号： H01L29/7834 ,  B82Y10/00 ,  G11B9/1409 ,  H01L21/28123 ,  H01L29/66636

摘要： A method of manufacturing an enhancement type semiconductor probe and an information storage device having the enhancement type semiconductor probe are provided. The method involves using an anisotropic wet etching and a side-wall in which influence of process parameters upon the performance of a device is reduced to improve reliability of the device in mass-production, and factors of degrading measuring sensitivity is removed to improve the performance of the device.

摘要翻译： 提供一种制造增强型半导体探针的方法和具有该增强型半导体探针的信息存储装置。 该方法包括使用各向异性湿蚀刻和侧壁，其中降低了工艺参数对器件性能的影响，以提高器件在批量生产中的可靠性，并且去除降低测量灵敏度的因素以提高性能 的设备。

公开(公告)号：US20090203708A1

公开(公告)日：2009-08-13

申请号：US12304670

申请日：2006-07-05

申请人： Churlmin Seong ,  Nosang Park ,  Jinil Choi ,  Chul Min Park ,  Wookyu Park ,  Jaeyang Kong

发明人： Churlmin Seong ,  Nosang Park ,  Jinil Choi ,  Chul Min Park ,  Wookyu Park ,  Jaeyang Kong

IPC分类号： A61K31/496 ,  C07D403/10 ,  A61P25/28

CPC分类号： C07D239/96 ,  C07D401/06 ,  C07D405/06

摘要： Disclosed herein are novel substituted-1H-quinazoline-2,4-dione derivatives, a preparation method thereof, and a pharmaceutical composition containing the same. The novel substituted-1H-quinazoline-2,4-dione derivatives are excellent in binding affinity and selectivity for 5-HT6 receptors over other receptors, inhibit serotonin(5-HT)-stimulated cAMP accumulation, and disrupt apomorphine(2 mg/kg, i.p.)-induced hyperactivity in rats. Thanks to these effects, the derivatives are useful in the treatment of 5-HT6 receptor-related central nervous system diseases.

摘要翻译： 本文公开了新的取代的1H-喹唑啉-2,4-二酮衍生物，其制备方法和含有该化合物的药物组合物。 新型取代的1H-喹唑啉-2,4-二酮衍生物对5-HT6受体与其他受体的结合亲和力和选择性优异，抑制5-羟色胺（5-HT）刺激的cAMP积聚，并破坏阿扑吗啡（2mg / kg ，ip）诱导大鼠活动过度。 由于这些效果，衍生物可用于治疗5-HT6受体相关的中枢神经系统疾病。

公开(公告)号：US20080220556A1

公开(公告)日：2008-09-11

申请号：US12043982

申请日：2008-03-07

申请人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

发明人： Hyoung Soo Ko ,  Byung Gook Park ,  Seung Bum Hong ,  Chul Min Park ,  Woo Young Choi ,  Jong Pil Kim ,  Jae Young Song ,  Sang Wan Kim

IPC分类号： H01L21/02

CPC分类号： H01L29/7834 ,  B82Y10/00 ,  G11B9/1409 ,  H01L21/28123 ,  H01L29/66636

摘要： A method of manufacturing an enhancement type semiconductor probe and an information storage device having the enhancement type semiconductor probe are provided. The method involves using an anisotropic wet etching and a side-wall in which influence of process parameters upon the performance of a device is reduced to improve reliability of the device in mass-production, and factors of degrading measuring sensitivity is removed to improve the performance of the device.

摘要翻译： 提供一种制造增强型半导体探针的方法和具有该增强型半导体探针的信息存储装置。 该方法包括使用各向异性湿蚀刻和侧壁，其中降低了工艺参数对器件性能的影响，以提高器件在批量生产中的可靠性，并且去除降低测量灵敏度的因素以提高性能 的设备。