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1.发明授权Asymmetric catalytic hydrogenation process for preparation of chiral cyclic &bgr;-aminoesters 失效用于制备手性环状β-氨基酸酯的不对称催化氢化方法公开(公告)号：US06835841B2
公开(公告)日：2004-12-28
申请号：US10660345
申请日：2003-09-11
申请人： Joerg Deerberg , Douglas D. McLeod , Tai-Yuen Yue
发明人： Joerg Deerberg , Douglas D. McLeod , Tai-Yuen Yue
IPC分类号： C07D21158
CPC分类号： C07D317/72 , C07D211/60 , C07D309/08
摘要： A novel process for the asymmetric synthesis of substituted cyclic &bgr;-amino-carboxylates of the type shown in the specification from appropriate &bgr;-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors.
摘要翻译： 描述了从合适的β-烯氨基酯起始原料不规则合成说明书中所示类型的取代的环状β-氨基 - 羧酸盐的新方法。 这些化合物可用作MMP和TACE抑制剂的中间体。
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2.发明授权公开(公告)号：US09000161B2
公开(公告)日：2015-04-07
申请号：US13761742
申请日：2013-02-07
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
IPC分类号： C07D487/00 , C07D487/04 , C07F7/18 , C07F7/10
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
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3.发明申请公开(公告)号：US20120058079A1
公开(公告)日：2012-03-08
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , A61P31/12 , A61P37/04 , A61P27/12 , A61P37/06 , C07D271/08 , A61K39/00 , A61K39/12 , A61K38/20 , A61K39/395 , C12N9/99 , A61P35/00 , A61P25/24
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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4.发明申请公开(公告)号：US20100190981A1
公开(公告)日：2010-07-29
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07D231/16 , C07F5/02
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
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公开(公告)号：US08796319B2
公开(公告)日：2014-08-05
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , C07D413/12 , C07D271/08
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
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6.发明申请公开(公告)号：US20140023663A1
公开(公告)日：2014-01-23
申请号：US14033117
申请日：2013-09-20
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： C07D271/08 , C07D413/12 , A61K39/395 , A61K31/4245
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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7.发明申请公开(公告)号：US20100015178A1
公开(公告)日：2010-01-21
申请号：US12498782
申请日：2009-07-07
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K39/12 , C07D271/08 , A61K31/4245 , C12N9/99 , A61P37/06 , A61P35/00 , A61P31/12 , A61P25/00 , A61P25/24 , A61P27/12 , A61K39/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
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公开(公告)号：US08993582B2
公开(公告)日：2015-03-31
申请号：US13761830
申请日：2013-02-07
申请人： Jiacheng Zhou , David Meloni , Pingli Liu , Brian W. Metcalf , Tai-Yuen Yue
发明人： Jiacheng Zhou , David Meloni , Pingli Liu , Brian W. Metcalf , Tai-Yuen Yue
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07F7/18 , C07F7/10
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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公开(公告)号：US08410265B2
公开(公告)日：2013-04-02
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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