-
1.发明申请公开(公告)号：US20100190981A1
公开(公告)日：2010-07-29
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07D231/16 , C07F5/02
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
-
公开(公告)号：US08410265B2
公开(公告)日：2013-04-02
申请号：US12687623
申请日：2010-01-14
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
-
3.发明授权公开(公告)号：US09000161B2
公开(公告)日：2015-04-07
申请号：US13761742
申请日：2013-02-07
申请人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , Brian W. Metcalf
IPC分类号： C07D487/00 , C07D487/04 , C07F7/18 , C07F7/10
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
摘要翻译： 本发明涉及制备式III的手性取代吡唑并吡咯并[2,3-d]嘧啶的方法和相关的合成中间体化合物。 手性取代的吡唑基吡咯并[2,3-d]嘧啶可用作Janus Kinase家族蛋白酪氨酸激酶（JAKs）的抑制剂，用于治疗炎性疾病，骨髓增生性疾病和其他疾病。
-
4.发明申请公开(公告)号：US20120058079A1
公开(公告)日：2012-03-08
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , A61P31/12 , A61P37/04 , A61P27/12 , A61P37/06 , C07D271/08 , A61K39/00 , A61K39/12 , A61K38/20 , A61K39/395 , C12N9/99 , A61P35/00 , A61P25/24
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
-
公开(公告)号：US08796319B2
公开(公告)日：2014-08-05
申请号：US13294711
申请日：2011-11-11
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K31/4245 , C07D413/12 , C07D271/08
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
-
6.发明申请公开(公告)号：US20140023663A1
公开(公告)日：2014-01-23
申请号：US14033117
申请日：2013-09-20
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： C07D271/08 , C07D413/12 , A61K39/395 , A61K31/4245
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
-
7.发明申请公开(公告)号：US20100015178A1
公开(公告)日：2010-01-21
申请号：US12498782
申请日：2009-07-07
申请人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
发明人： Andrew P. Combs , Eddy W. Yue , Richard B. Sparks , Wenyu Zhu , Jiacheng Zhou , Qiyan Lin , Lingkai Weng , Tai-Yuen Yue , Pingli Liu
IPC分类号： A61K39/12 , C07D271/08 , A61K31/4245 , C12N9/99 , A61P37/06 , A61P35/00 , A61P31/12 , A61P25/00 , A61P25/24 , A61P27/12 , A61K39/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
摘要翻译： 本发明涉及1,2,5-恶二唑衍生物及其组合物，其为吲哚胺2,3-双加氧酶的抑制剂，可用于治疗癌症和其它疾病，以及其用于治疗癌症和其它疾病的方法和中间体 制备这样的1,2,5-恶二唑衍生物。
-
公开(公告)号：US06825210B2
公开(公告)日：2004-11-30
申请号：US10124105
申请日：2002-04-17
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745
摘要： The present invention relates to tricyclic compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译： 本发明涉及可用作HIV逆转录酶抑制剂的式（I）的三环化合物或其立体异构形式，立体异构体混合物或其药学上可接受的盐形式，以及包含其的药物组合物和诊断试剂盒及方法 使用它们来治疗病毒感染或作为测定标准或试剂。
-
公开(公告)号：US5952376A
公开(公告)日：1999-09-14
申请号：US966428
申请日：1997-11-07
申请人： Amos B. Smith, III , Qiyan Lin
发明人： Amos B. Smith, III , Qiyan Lin
IPC分类号： C07C303/22 , C07D309/10 , A61K31/35 , A61K31/38 , A61K31/445
CPC分类号： C07D309/10
摘要： Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.
摘要翻译： 提供了模仿海绵体的化学和/或生物活性的含有三烯的化合物，以及可用于其制备的方法和中间体。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.049 秒)
