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    Benzopyranopyrazolyl derivatives for the treatment of inflammation
    2.
    发明授权
    Benzopyranopyrazolyl derivatives for the treatment of inflammation 失效
    苯并吡喃并吡唑衍生物用于治疗炎症

    公开(公告)号：US5547975A

    公开(公告)日：1996-08-20

    申请号：US309291

    申请日：1994-09-20

    申请人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    发明人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    IPC分类号： C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  A61K31/415 ,  A61K31/63

    CPC分类号： C07D491/04 ,  C07D495/04

    摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。 其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

    Heteroarylpyranopyrazolyl derivatives for the treatment of inflammation
    8.
    发明授权
    Heteroarylpyranopyrazolyl derivatives for the treatment of inflammation 失效
    异芳基吡喃并吡唑衍生物用于治疗炎症

    公开(公告)号：US5565482A

    公开(公告)日：1996-10-15

    申请号：US536925

    申请日：1995-09-29

    申请人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    发明人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    IPC分类号： C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  A61K31/415 ,  C07D491/14

    CPC分类号： C07D491/04 ,  C07D495/04

    摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。 其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。

    Pyrazolyl derivatives for the treatment of inflammation
    9.
    发明授权
    Pyrazolyl derivatives for the treatment of inflammation 失效
    吡唑基衍生物用于治疗炎症

    公开(公告)号：US5670532A

    公开(公告)日：1997-09-23

    申请号：US719501

    申请日：1996-09-25

    申请人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    发明人： John J. Talley ,  Stephen R. Bertenshaw ,  Matthew J. Graneto ,  Donald J. Rogier

    IPC分类号： C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  A61K31/415 ,  A61K31/435 ,  C07D487/04

    CPC分类号： C07D491/04 ,  C07D495/04

    摘要： A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein A is --(CH.sub.2).sub.m --X--(CH.sub.2).sub.n --; wherein X is S(O).sub.p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R.sup.1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R.sup.2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R.sup.4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 描述了一类苯并吡喃并吡唑基衍生物用于治疗炎症和炎症相关疾病。 特别感兴趣的化合物由式I（I）定义，其中A是 - （CH 2）m -X-（CH 2）n - ; 其中X是S（O）p或O; 其中m为0或1; 其中n为0或1; 其中p为0或1; 其中B选自苯基和五元和六元杂芳基; 其中R 1选自低级卤代烷基，氰基，甲酰基，低级烷氧基羰基，低级烷氧基，低级N-烷基氨基羰基，N-苯基氨基羰基，低级N，N-二烷基氨基羰基和低级N-烷基-N-苯基氨基羰基。 其中R2是在可取代的位置被选自低级烷基磺酰基和氨磺酰基的基团取代的苯基; 氰基，羧基，低级烷氧基羰基，氨基羰基，低级卤代烷基，羟基，低级烷氧基，氨基，低级N-烷基氨基，低级N，低级烷基氨基，低级烷基氨基，低级烷基氨基， N-二烷基氨基，低级羟烷基和低级卤代烷氧基; 或其药学上可接受的盐。