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    High impedance active fixation electrode of an electrical medical lead
    1.
    发明申请
    High impedance active fixation electrode of an electrical medical lead 有权
    电气医用引线的高阻抗主动固定电极

    公开(公告)号：US20060122682A1

    公开(公告)日：2006-06-08

    申请号：US11004744

    申请日：2004-12-03

    申请人： John Sommer ,  Daniel Sigg ,  James Coles

    发明人： John Sommer ,  Daniel Sigg ,  James Coles

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0573

    摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.

    摘要翻译： 公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织 螺钉固定螺旋引起的损伤。 在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。 在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

    Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel
    4.
    发明申请
    Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel 审中-公开
    通过抑制钾内向整流通道的表达来治疗心脏疾病的方法

    公开(公告)号：US20050244377A1

    公开(公告)日：2005-11-03

    申请号：US11022368

    申请日：2004-12-22

    申请人： Daniel Sigg ,  James Coles ,  Michael Ujhelyi ,  Rudy Padua ,  Daisy Cross ,  William Kaemmerer

    发明人： Daniel Sigg ,  James Coles ,  Michael Ujhelyi ,  Rudy Padua ,  Daisy Cross ,  William Kaemmerer

    IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/86

    CPC分类号： C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention is directed toward methods for regulating biological pacemaking activity and devices used in such regulation. Such regulation can be accomplished by introducing genetic material to the heart by transfecting heart cells of the atrium or ventricle with an oligonucleotide, small interfering RNA, that silence KCNJ2, and suppress the IK1 current. Suppression (or silencing) of KCNJ2 subsequently induces pacemaker-like activities in previously regular myocytes. This invention provides for methods of targeted delivery using a fluid delivery catheter. Such a catheter allows the targeting of a specific area in the atrium or the ventricle of the heart. Also, combination methods of treating arrhythmia with traditional device-based therapies (e.g., pacemakers and defibrillators) and an oligonucleotide of the subject invention.

    摘要翻译： 本发明涉及用于调节生物起搏活性的方法和用于这种调节的装置。 通过用心脏或心室的心脏细胞转染心脏的遗传物质可以通过用沉默KCNJ2的寡核苷酸，小干扰RNA，抑制Iκ1电流来引入遗传物质来实现这种调节。 KCNJ2的抑制（或沉默）随后在以前的正常心肌细胞中诱导起搏器样活性。 本发明提供了使用流体输送导管进行靶向递送的方法。 这样的导管允许靶向心房的心房或心室的特定区域。 此外，用传统的基于装置的疗法（例如起搏器和除颤器）治疗心律失常的组合方法和本发明的寡核苷酸。

    Antithrombogenic medical device
    5.
    发明申请
    Antithrombogenic medical device 审中-公开
    抗血栓形成医疗器械

    公开(公告)号：US20050165452A1

    公开(公告)日：2005-07-28

    申请号：US10766792

    申请日：2004-01-28

    申请人： Daniel Sigg ,  James Coles

    发明人： Daniel Sigg ,  James Coles

    IPC分类号： A61N1/05 ,  A61N1/18 ,  A61N1/30 ,  A61N1/372 ,  A61N1/39

    CPC分类号： A61N1/056 ,  A61N1/0568 ,  A61N1/0575

    摘要： A therapy delivery and/or diagnostic device includes a layer of a catalytic agent, having nitrite reductase and/or nitrate reductase, or nitrosothiol reductase activity. The catalytic layer converts nitrate/nitrate or nitrosothiols to nitric oxide when in contact with blood.

    摘要翻译： 治疗递送和/或诊断装置包括具有亚硝酸还原酶和/或硝酸还原酶或亚硝基硫醇还原酶活性的催化剂层。 当与血液接触时，催化层将硝酸盐/硝酸盐或亚硝基硫醇转化成一氧化氮。

    Method for fabrication of low-polarization implantable stimulation electrode
    6.
    发明申请
    Method for fabrication of low-polarization implantable stimulation electrode 有权
    低极化可植入刺激电极的制造方法

    公开(公告)号：US20060167536A1

    公开(公告)日：2006-07-27

    申请号：US11042649

    申请日：2005-01-25

    申请人： Lea Nygren ,  James Coles ,  Scott Brabec ,  Randy Rose

    发明人： Lea Nygren ,  James Coles ,  Scott Brabec ,  Randy Rose

    IPC分类号： A61N1/05

    CPC分类号： A61N1/05 ,  C23C28/32 ,  Y10T29/49204

    摘要： A method for fabricating an implantable medical electrode includes roughening the electrode substrate, applying an adhesion layer, and depositing a valve metal oxide coating over the adhesion layer under conditions optimized to minimize electrode impedance and post-pulse polarization. The electrode substrate may be a variety of electrode metals or alloys including titanium, platinum, platinum-iridium, or niobium. The adhesion layer may be formed of titanium or zirconium. The valve metal oxide coating is a ruthenium oxide coating sputtered onto the adhesion layer under controlled target power, sputtering pressure, and sputter gas ratio setting optimized to minimize electrode impedance and post-pulse polarization.

    摘要翻译： 一种用于制造可植入医疗电极的方法包括使电极基板粗糙化，施加粘合层，以及在优化以最小化电极阻抗和脉冲后极化的条件下，在粘附层上沉积阀金属氧化物涂层。 电极基板可以是各种电极金属或包括钛，铂，铂 - 铱或铌的合金。 粘合层可以由钛或锆形成。 阀金属氧化物涂层是在受控目标功率，溅射压力和溅射气体比设置下溅射到粘附层上的氧化钌涂层，其被优化以最小化电极阻抗和后脉冲极化。