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    Method and apparatus for providing intra-pericardial access
    2.
    发明授权
    Method and apparatus for providing intra-pericardial access 有权
    用于提供心包内通路的方法和装置

    公开(公告)号：US07207988B2

    公开(公告)日：2007-04-24

    申请号：US10606908

    申请日：2003-06-26

    申请人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    发明人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    IPC分类号： A61B18/14

    CPC分类号： A61B17/3478 ,  A61B17/3417 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2017/3443 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392

    摘要： A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially. The tubular member may be passed through the wall of the heart or the pericardium in its extended configuration and thereafter, the distal-most portion of the tubular member may be moved proximally, causing its diameter enlarge, anchoring the distal end of the catheter or cannula to the pericardium or to the wall of a heart chamber. In these embodiments, the device is preferably provided with a shoulder or flange located proximal to the extendible tubular member, for location on the opposite side of the heart wall or pericardium from the distal end of the catheter or cannula.

    摘要翻译： 一种用于进入心包空间的方法和装置，其提供其最远端位于心包空间中的输送导管或插管的稳定的短期或长期放置。 导管或插管可以通过穿透胸壁和心包而经心脏穿过心室的壁或经胸腔引入心包空间。 一些实施例设置有用于稳定导管或插管的远端的机构，该机构可以使用位于导管或插管的远端处的可伸展的弹性大体管状构件。 该装置可以设置有用于纵向延伸管状构件的机构，从而使其直径基本上减小。 管状构件可以以其延伸构型穿过心脏壁或心包，此后，管状构件的最远端部分可以向近侧移动，导致其直径增大，将导管或套管的远端固定 到心包室或心室的壁。 在这些实施例中，装置优选地设置有位于可伸缩管状构件的近侧的肩部或凸缘，用于位于与导管或插管远端的心脏壁或心包相反的一侧。

    Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel
    6.
    发明申请
    Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel 审中-公开
    通过抑制钾内向整流通道的表达来治疗心脏疾病的方法

    公开(公告)号：US20050244377A1

    公开(公告)日：2005-11-03

    申请号：US11022368

    申请日：2004-12-22

    申请人： Daniel Sigg ,  James Coles ,  Michael Ujhelyi ,  Rudy Padua ,  Daisy Cross ,  William Kaemmerer

    发明人： Daniel Sigg ,  James Coles ,  Michael Ujhelyi ,  Rudy Padua ,  Daisy Cross ,  William Kaemmerer

    IPC分类号： A61K48/00 ,  C12N15/113 ,  C12N15/86

    CPC分类号： C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention is directed toward methods for regulating biological pacemaking activity and devices used in such regulation. Such regulation can be accomplished by introducing genetic material to the heart by transfecting heart cells of the atrium or ventricle with an oligonucleotide, small interfering RNA, that silence KCNJ2, and suppress the IK1 current. Suppression (or silencing) of KCNJ2 subsequently induces pacemaker-like activities in previously regular myocytes. This invention provides for methods of targeted delivery using a fluid delivery catheter. Such a catheter allows the targeting of a specific area in the atrium or the ventricle of the heart. Also, combination methods of treating arrhythmia with traditional device-based therapies (e.g., pacemakers and defibrillators) and an oligonucleotide of the subject invention.

    摘要翻译： 本发明涉及用于调节生物起搏活性的方法和用于这种调节的装置。 通过用心脏或心室的心脏细胞转染心脏的遗传物质可以通过用沉默KCNJ2的寡核苷酸，小干扰RNA，抑制Iκ1电流来引入遗传物质来实现这种调节。 KCNJ2的抑制（或沉默）随后在以前的正常心肌细胞中诱导起搏器样活性。 本发明提供了使用流体输送导管进行靶向递送的方法。 这样的导管允许靶向心房的心房或心室的特定区域。 此外，用传统的基于装置的疗法（例如起搏器和除颤器）治疗心律失常的组合方法和本发明的寡核苷酸。

    Methods and systems for providing therapies into the pericardial space
    7.
    发明申请
    Methods and systems for providing therapies into the pericardial space 审中-公开
    用于向心包空间提供疗法的方法和系统

    公开(公告)号：US20050154370A1

    公开(公告)日：2005-07-14

    申请号：US11000538

    申请日：2004-12-01

    申请人： Daniel Sigg ,  Michael Ujhelyi ,  Mary Morris

    发明人： Daniel Sigg ,  Michael Ujhelyi ,  Mary Morris

    IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/34 ,  A61B18/14 ,  A61M31/00

    CPC分类号： A61M5/14276 ,  A61B17/00234 ,  A61B17/3417 ,  A61B17/3478 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61M5/1723 ,  A61M2005/1405 ,  A61M2205/3523

    摘要： Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.

    摘要翻译： 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以向心脏递送药理学特别是NO供体药物。 输注导管的近端连接器联接到输注泵，并且具有远端输注导管腔端部开口的远侧导管段设置在心包空间中。 可植入输注泵可与可植入缺血监测器结合操作以监测缺血状态并触发递送或调节药理学剂的周期性递送以最佳地治疗缺血。 患者可以操作患者活化剂，当感觉到缺血症状时患者传递由可植入输液泵接收的信号并触发推注和/或连续输注的传递。

    Method and apparatus for providing intra-pericardial access
    8.
    发明授权
    Method and apparatus for providing intra-pericardial access 有权
    用于提供心包内通路的方法和装置

    公开(公告)号：US06613062B1

    公开(公告)日：2003-09-02

    申请号：US09430096

    申请日：1999-10-29

    申请人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    发明人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    IPC分类号： A61B1732

    CPC分类号： A61B17/3478 ,  A61B17/3417 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2017/3443 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392

    摘要： A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially. The tubular member may be passed through the wall of the heart or the pericardium in its extended configuration and thereafter, the distal-most portion of the tubular member may be moved proximally, causing its diameter enlarge, anchoring the distal end of the catheter or cannula to the pericardium or to the wall of a heart chamber. In these embodiments, the device is preferably provided with a shoulder or flange located proximal to the extendible tubular member, for location on the opposite side of the heart wall or pericardium from the distal end of the catheter or cannula.

    摘要翻译： 一种用于进入心包空间的方法和装置，其提供其最远端位于心包空间中的输送导管或插管的稳定的短期或长期放置。 导管或插管可以通过穿透胸壁和心包而经心脏穿过心室的壁或经胸腔引入心包空间。 一些实施例设置有用于稳定导管或插管的远端的机构，该机构可以使用位于导管或插管的远端处的可伸展的弹性大体管状构件。 该装置可以设置有用于纵向延伸管状构件的机构，从而使其直径基本上减小。 管状构件可以以其延伸构型穿过心脏壁或心包，此后，管状构件的最远端部分可向近侧移动，导致其直径增大，将导管或插管的远端固定 到心包室或心室的壁。 在这些实施例中，装置优选地设置有位于可伸缩管状构件的近侧的肩部或凸缘，用于位于与导管或插管远端的心脏壁或心包相反的一侧。

    Method and apparatus for providing intra-pericardial access
    9.
    发明授权
    Method and apparatus for providing intra-pericardial access 有权

    公开(公告)号：US08475468B2

    公开(公告)日：2013-07-02

    申请号：US10606909

    申请日：2003-06-26

    申请人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    发明人： Michael E. Leckrone ,  Timothy G. Laske ,  Michael Ujhelyi

    IPC分类号： A61F11/00

    CPC分类号： A61B17/3478 ,  A61B17/3417 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/22077 ,  A61B2017/3443 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392

    摘要： A method and apparatus for accessing the pericardial space which provides for stable short term or long term placement of a delivery catheter or cannula having its distal most end located in the pericardial space. The catheter or cannula may be introduced into the pericardial space either transvenously through the wall of a heart chamber or transthoracically by penetrating the chest wall and the pericardium. Some embodiments are provided with a mechanism for stabilizing the distal end of the catheter or cannula, which mechanism may employ an extensible elastic, generally tubular member located at the distal end of the catheter or cannula. The device may be provided with a mechanism for extending the tubular member longitudinally, causing its diameter to diminish substantially. The tubular member may be passed through the wall of the heart or the pericardium in its extended configuration and thereafter, the distal-most portion of the tubular member may be moved proximally, causing its diameter enlarge, anchoring the distal end of the catheter or cannula to the pericardium or to the wall of a heart chamber. In these embodiments, the device is preferably provided with a shoulder or flange located proximal to the extendible tubular member, for location on the opposite side of the heart wall or pericardium from the distal end of the catheter or cannula.