公开(公告)号：US20070089874A1

公开(公告)日：2007-04-26

申请号：US11584911

申请日：2006-10-23

申请人： John Tuntland ,  Ronald Dupree ,  Sean Johnson ,  Deepak Tiwari ,  Roland Weisman ,  Jennifer Wu ,  Eugene Zueck

发明人： John Tuntland ,  Ronald Dupree ,  Sean Johnson ,  Deepak Tiwari ,  Roland Weisman ,  Jennifer Wu ,  Eugene Zueck

IPC分类号： F01P1/06 ,  G05D15/00

CPC分类号： F28F9/0234 ,  F28F9/22 ,  F28F2009/224

摘要： A cooling system for a work machine may comprise a reservoir configured to hold a supply of fluid, a source of pressurized fluid and a valve configured to receive the pressurized fluid from the source of pressurized fluid. A first working unit and a second working unit may be connected to the valve in parallel. One of The first and second working units may be adapted to receive pressurized fluid on a priority basis from the valve. The first and second working units may be fluidly connected to the reservoir by a circulation conduit and may be connected to a first heat exchanger by a bypass conduit. The bypass conduit may be configured to pass only a portion of the fluid flow to be passed from the first and second working units to the first heat exchanger. The first heat exchanger may be fluidly connected to the reservoir and may be adapted to pass the portion of the fluid flow to the reservoir.

摘要翻译： 用于作业机器的冷却系统可以包括构造成保持流体供应源，加压流体源和被配置为从加压流体源接收加压流体的阀的储存器。 第一工作单元和第二工作单元可以并联连接到阀。 第一和第二工作单元之一可以适于从阀门优先接收加压流体。 第一和第二工作单元可以通过循环管道流体地连接到储存器，并且可以通过旁路管道连接到第一热交换器。 旁通管道可以被配置为仅将待通过的流体流的一部分从第一和第二工作单元传递到第一热交换器。 第一热交换器可以流体地连接到储存器并且可以适于将流体流的一部分传递到储存器。

公开(公告)号：US20070095504A1

公开(公告)日：2007-05-03

申请号：US11584912

申请日：2006-10-23

申请人： John Tuntland ,  Sean Johnson ,  Ronald Dupree ,  Deepak Tiwari ,  Roland Weisman ,  Jennifer Wu ,  Eugene Zueck

发明人： John Tuntland ,  Sean Johnson ,  Ronald Dupree ,  Deepak Tiwari ,  Roland Weisman ,  Jennifer Wu ,  Eugene Zueck

IPC分类号： B60H1/00

CPC分类号： F28F9/0234 ,  B60H1/00328 ,  F28F9/22 ,  F28F2009/224

摘要： A radiator may have a first cooler that may be connected to a lower end portion of the radiator. The first cooler may comprise a bottom compartment. The bottom compartment may have a front wall, a rear wall, first and second spaced apart side walls, a bottom wall and a lower portion. A radiator outlet port member may be connected to the lower portion. A cooling core may be positioned in the bottom compartment. A baffle may be connected to the bottom compartment and positioned above the cooling core. An opening may be disposed in the baffle at a location closer to a one of the first and second side walls than another of said first and second walls.

摘要翻译： 散热器可以具有可以连接到散热器的下端部分的第一冷却器。 第一冷却器可以包括底部隔室。 底部隔室可以具有前壁，后壁，第一和第二间隔开的侧壁，底壁和下部。 散热器出口端口构件可以连接到下部。 冷却芯可以定位在底部隔室中。 挡板可以连接到底部隔间并且位于冷却芯的上方。 开口可以设置在挡板中比第一和第二壁中的另一个更靠近第一和第二侧壁中的一个的位置处。

公开(公告)号：US20080293814A1

公开(公告)日：2008-11-27

申请号：US11752037

申请日：2007-05-22

申请人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

发明人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

IPC分类号： A61K31/195

CPC分类号： A61K31/216 ,  A61K9/0019 ,  A61K31/195 ,  A61K31/215 ,  A61K31/24 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26

摘要： A concentrate esmolol formulation is provided that is safer than current concentrate (e.g., 250 mg/ml) esmolol compositions. The concentrate esmolol formulation can include from about 40-60 mg/ml of esmolol hydrochloride. The concentrate esmolol composition allows a practitioner the flexibility of choosing a bolus volume for direct injection to a patient or, optionally, to use the composition to make a customized, diluted composition of esmolol. Methods of the present invention provide for the reduction of potential adverse health consequences resulting in the improper dosing of prior art concentrate compositions of esmolol. Also, a medical product is provided that includes a concentrate esmolol housed in a container, and a package housing the container and instructions.

摘要翻译： 提供比当前浓缩物（例如250mg / ml）艾司洛尔组合物更安全的浓缩艾司洛尔制剂。 浓缩艾司洛尔制剂可以包括约40-60mg / ml的盐酸艾司洛尔。 浓缩艾司洛尔组合物允许从业者灵活地选择推注体积以直接注射给患者，或者任选地使用组合物制备定制的，稀释的艾司洛尔组合物。 本发明的方法提供减少潜在的不利健康后果，导致不适当地给予艾司洛尔浓缩组合物的现有技术。 此外，提供了包括容纳在容器中的浓缩物艾司洛尔的医疗产品和容纳容器的包装和说明书。

公开(公告)号：US08426467B2

公开(公告)日：2013-04-23

申请号：US11752086

申请日：2007-05-22

申请人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

发明人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

IPC分类号： A01N37/10 ,  A01N37/44 ,  A61K31/235 ,  A61K31/24

CPC分类号： A61K31/24 ,  A61K9/0019

摘要： A concentrated esmolol formulation is provided that is distinguishable from a diluted form of the concentrated esmolol formulation.

摘要翻译： 提供浓缩艾司洛尔制剂，其与浓缩艾司洛尔制剂的稀释形式区分开。

公开(公告)号：US20080292558A1

公开(公告)日：2008-11-27

申请号：US11752086

申请日：2007-05-22

申请人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

发明人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

IPC分类号： A61K31/24 ,  A61P43/00 ,  C07C229/00

CPC分类号： A61K31/24 ,  A61K9/0019

摘要： A concentrated esmolol formulation is provided that is distinguishable from a diluted form of the concentrated esmolol formulation. In one embodiment, the concentrated esmolol formulation allows identification of the concentrate even after transfer of the concentrate out of a labeled primary container. The concentrated esmolol formulation can include from about 25 to about 1000 mg/ml of esmolol hydrochloride, a buffering agent and a color additive. Any number of color additives may be included such as indocyanine green, phenopheylene, hemoglobin, cyanocobalamine, patent blue, and indigo carmine vitamin B2 and naturally occurring vitamins and minerals. The amount included in the formulation is highly dependent on the color additive selected. The color additive should be included in an amount sufficient to easily distinguish the concentrated esmolol formulation from at least about a 1:4 dilution of the concentrate. Also, a medical product is provided that includes a colored concentrated esmolol housed in a container, and a package housing the container and instructions. The instructions can notify that a color additive has been added to the concentrated esmolol formulation to aid in differentiating it. Additionally a method of allowing easy identification of a concentrated esmolol formulation is provided. The method includes providing a colored concentrated esmolol formulation that has from about 25 to about 1000 mg/ml of esmolol and a color additive.

摘要翻译： 提供浓缩艾司洛尔制剂，其与浓缩艾司洛尔制剂的稀释形式区分开。 在一个实施方案中，浓缩的艾司洛尔制剂允许即使在将浓缩物从标记的一次性容器转移出来之后也可以鉴定浓缩物。 浓缩的艾司洛尔制剂可以包括约25至约1000mg / ml的盐酸艾司洛尔，缓冲剂和颜色添加剂。 可以包括任何数量的着色添加剂，例如吲哚菁绿，苯乙烯，血红蛋白，氰钴胺，专利蓝和靛蓝胭脂红维生素B2和天然存在的维生素和矿物质。 制剂中包含的量高度依赖于所选择的颜色添加剂。 颜料添加剂的含量应足以容易地将浓缩的艾司洛尔制剂与浓缩物的至少约1:4稀释度区分开来。 此外，提供了一种医疗产品，其包括容纳在容器中的着色浓缩艾司洛尔，以及容纳容器和指令的包装。 说明书可以通知已将色素添加剂加入到浓缩的艾司洛尔制剂中以有助于区分它。 另外，提供了容易鉴定浓缩艾司洛尔制剂的方法。 该方法包括提供具有约25至约1000mg / ml艾司洛尔和着色添加剂的着色浓缩艾司洛尔制剂。

公开(公告)号：US08722736B2

公开(公告)日：2014-05-13

申请号：US11752103

申请日：2007-05-22

申请人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

发明人： Deepak Tiwari ,  George Owoo ,  Rekha Nayak ,  Kenneth E. Burhop

IPC分类号： A61K31/24

CPC分类号： A61K31/24 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/12

摘要： Disclosed are concentrate esmolol injection essentially free from other related esters of esmolol and diluted esmolol compositions. The concentrate esmolol formulation includes from about 25-1000 mg/ml of esmolol and about 1-25% w/v of benzyl alcohol and the combination thereof. The compositions can also be used as multi-dose compositions. The present invention also discloses diluted, ready-to-use compositions of esmolol prepared by dilution of the present invention concentrates. Also disclosed are methods of making and using the ready-to-use compositions of the present invention.

摘要翻译： 公开了基本上不含艾司洛尔和稀释艾司洛尔组合物的其它相关酯的浓缩艾司洛尔注射液。 浓缩艾司洛尔制剂包括约25-1000mg / ml的艾司洛尔和约1-25％w / v的苄醇及其组合。 组合物也可以用作多剂量组合物。 本发明还公开了通过稀释本发明浓缩物制备的稀释的即用型艾司洛尔组合物。 还公开了制备和使用本发明的即用组合物的方法。

公开(公告)号：US20080293810A1

公开(公告)日：2008-11-27

申请号：US11752103

申请日：2007-05-22

申请人： Deepak Tiwari ,  George Owoo ,  Rekha nayak ,  kenneth E. Burhop

发明人： Deepak Tiwari ,  George Owoo ,  Rekha nayak ,  kenneth E. Burhop

IPC分类号： A61K31/24 ,  A61P9/00 ,  C07C229/02

CPC分类号： A61K31/24 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/12

摘要： Disclosed are concentrate esmolol injection essentially free from other related esters of esmolol and diluted esmolol compositions. The concentrate esmolol formulation includes from about 25-1000 mg/ml of esmolol and about 1-25% w/v of benzyl alcohol and the combination thereof. The compositions can also be used as multi-dose compositions. The present invention also discloses diluted, ready-to-use compositions of esmolol prepared by dilution of the present invention concentrates. Also disclosed are methods of making and using the ready-to-use compositions of the present invention.

摘要翻译： 公开了基本上不含艾司洛尔和稀释艾司洛尔组合物的其它相关酯的浓缩艾司洛尔注射液。 浓缩艾司洛尔制剂包括约25-1000mg / ml的艾司洛尔和约1-25％w / v的苄醇及其组合。 组合物也可以用作多剂量组合物。 本发明还公开了通过稀释本发明浓缩物制备的稀释的即用型艾司洛尔组合物。 还公开了制备和使用本发明的即用组合物的方法。