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公开(公告)号：US20220022883A1
公开(公告)日：2022-01-27
申请号：US17496328
申请日：2021-10-07
申请人： Jonathan Hartman , Lawrence Livermore National Security, Inc. , The Texas A&M University System
发明人： Jason M. Ortega , William J. Benett , Ward Small , Thomas S. Wilson , Duncan J. Maitland , Jonathan Hartman
IPC分类号： A61B17/12
摘要： A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
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公开(公告)号：US20140277057A1
公开(公告)日：2014-09-18
申请号：US13798740
申请日：2013-03-13
发明人： Jason M. Ortega , William J. Benett , Ward Small , Thomas S. Wilson , Duncan J. Maitland , Jonathan Hartman
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12031 , A61B17/12181 , A61B2017/0061 , A61B2017/00871 , A61B2017/12077
摘要： A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
摘要翻译： 一种用于治疗血管或静脉中的动脉瘤的系统，其中所述动脉瘤具有圆顶，内部和颈部。 该系统包括在圆顶和颈部之间的动脉瘤内部的形状记忆聚合物泡沫。 形状记忆聚合物泡沫具有包括具有第一孔径的第一多个孔和具有第二孔径的第二多个孔的孔。 第二孔径大于所述第一孔径。 第一个多孔的孔位于动脉瘤的颈部。 孔的第二个多重性位于动脉瘤的圆顶。
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公开(公告)号：US11141164B2
公开(公告)日：2021-10-12
申请号：US15599133
申请日：2017-05-18
发明人： Jason M. Ortega , William J. Benett , Ward Small , Thomas S. Wilson , Duncan J. Maitland , Jonathan Hartman
摘要： A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
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公开(公告)号：US20170252045A1
公开(公告)日：2017-09-07
申请号：US15599133
申请日：2017-05-18
发明人： Jason M. Ortega , William J. Benett , Ward Small , Thomas S. Wilson , Duncan J. Maitland , Jonathan Hartman
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12031 , A61B17/12181 , A61B2017/0061 , A61B2017/00871 , A61B2017/12077
摘要： A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
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公开(公告)号：US20220323079A1
公开(公告)日：2022-10-13
申请号：US17846449
申请日：2022-06-22
发明人： Duncan J. Maitland , Todd L. Landsman , Jennifer N. Rodriguez , Anthony J. Boyle , Alan C. Glowczwski , Mark A. Wierzbicki
IPC分类号： A61B17/12
摘要： An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit.
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公开(公告)号：US11369385B2
公开(公告)日：2022-06-28
申请号：US17032270
申请日：2020-09-25
发明人： Duncan J. Maitland , Todd L. Landsman , Jennifer N. Rodriguez , Anthony J. Boyle , Alan C. Glowczwski , Mark A. Wierzbicki
摘要： An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit.
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公开(公告)号：US20210338880A1
公开(公告)日：2021-11-04
申请号：US17335316
申请日：2021-06-01
发明人： Duncan J. Maitland , Todd Lawrence Landsman , Tyler Joseph Touchet , Elizabeth L. Cosgriff-Hernandez , Thomas S. Wilson
摘要： An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.
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公开(公告)号：US11109869B2
公开(公告)日：2021-09-07
申请号：US16776638
申请日：2020-01-30
摘要： An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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公开(公告)号：US20200339730A1
公开(公告)日：2020-10-29
申请号：US16924819
申请日：2020-07-09
摘要： An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US20200222595A1
公开(公告)日：2020-07-16
申请号：US16777190
申请日：2020-01-30
摘要： An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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