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公开(公告)号：US20250145758A1
公开(公告)日：2025-05-08
申请号：US19015925
申请日：2025-01-10
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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2.发明申请公开(公告)号：US20200253616A1
公开(公告)日：2020-08-13
申请号：US16776638
申请日：2020-01-30
Inventor： Anthony Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arteriovenous malformations, tissue engineering, and wound healing.
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公开(公告)号：US20180009932A1
公开(公告)日：2018-01-11
申请号：US15548212
申请日：2016-02-02
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
IPC: C08G18/32 , C08G18/67 , C08G18/75 , B29K105/04
CPC classification number: C08G18/3206 , B29K2105/04 , C08G18/3212 , C08G18/6715 , C08G18/675 , C08G18/73 , C08G18/758 , C08L75/04 , C08L75/16 , C08L81/02
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US20230250212A1
公开(公告)日：2023-08-10
申请号：US18189277
申请日：2023-03-24
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
CPC classification number: C08G18/3206 , C08G18/6715 , C08G18/758 , C08G18/3212 , C08L81/02 , C08L75/16 , C08L75/04 , C08G18/675 , C08G18/73 , B29K2105/04
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US11613603B2
公开(公告)日：2023-03-28
申请号：US16924819
申请日：2020-07-09
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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Patent Agency Ranking
公开(公告)号：US10561765B2
公开(公告)日：2020-02-18
申请号：US15746574
申请日：2016-07-22
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US11369720B2
公开(公告)日：2022-06-28
申请号：US16777190
申请日：2020-01-30
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US10548608B2
公开(公告)日：2020-02-04
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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9.发明申请公开(公告)号：US20180177508A1
公开(公告)日：2018-06-28
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
CPC classification number: A61B17/12181 , A61B17/12031 , A61B17/12113 , A61B17/1219 , A61B2017/00871 , A61B2017/00938 , A61B2017/00964 , A61L31/06 , A61L31/14 , A61L31/146 , A61L2400/16 , A61L2430/36 , C08L75/04
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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公开(公告)号：US12220502B2
公开(公告)日：2025-02-11
申请号：US17847426
申请日：2022-06-23
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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