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公开(公告)号:US07131960B2
公开(公告)日:2006-11-07
申请号:US09976798
申请日:2001-10-12
申请人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号: A61B17/20
CPC分类号: A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150824 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046
摘要: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译: 描述了一种方法和装置,用于将包括多个微突出物(90)的微量挤压构件(44)施加到角质层上。 该方法和装置用于改善药剂在皮肤上的运输,用于药剂递送或取样。 施加器(10,60,80)导致微推进构件(44)以确定的一定量的冲击力冲击角质层,以有效地用微突起(90)刺穿皮肤。 优选的施用器(10,60,80)在微滴注构件(44)中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件(44)的冲击角 减。
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公开(公告)号:US07419481B2
公开(公告)日:2008-09-02
申请号:US11092800
申请日:2005-03-28
申请人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号: A61M31/00
CPC分类号: A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150908 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译: 描述了一种方法和装置,用于将包括多个微突出物(90)的微量挤压构件(44)施加到角质层上。 该方法和装置用于改善药剂在皮肤上的运输,用于药剂递送或取样。 施加器(10,60,80)导致微推进构件(44)以确定的一定量的冲击力冲击角质层,以有效地用微突起(90)刺穿皮肤。 优选的施用器(10,60,80)在微滴注构件(44)中以10毫秒或更小的速度冲击至少0.05焦耳/微米/ 2微米输注构件(44)的冲击角 减。
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公开(公告)号:US07798987B2
公开(公告)日:2010-09-21
申请号:US11092202
申请日:2005-03-28
申请人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
发明人: Joseph C. Trautman , Richard L. Keenan , Ahmad P. Samiee , WeiQi Lin , Michel J. N. Cormier , James A. Matriano , Peter E. Daddona
IPC分类号: A61B17/20
CPC分类号: A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150824 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046
摘要: A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.
摘要翻译: 描述了一种方法和装置,用于将包括多个微突出物(90)的微量挤压构件(44)施加到角质层上。 该方法和装置用于改善药剂在皮肤上的运输,用于药剂递送或取样。 施加器(10,60,80)导致微推进构件(44)以确定的一定量的冲击力冲击角质层,以有效地用微突起(90)刺穿皮肤。 优选的施加器(10,60,80)在微滴注构件(44)中以10毫秒或更短的冲击速率冲击至少0.05焦耳/ cm2的微推进构件(44)。
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