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    Coupling low-molecular substances to a modified polysaccharide
    1.
    发明授权
    Coupling low-molecular substances to a modified polysaccharide 失效
    将低分子物质与改性多糖偶联

    公开(公告)号：US08466277B2

    公开(公告)日：2013-06-18

    申请号：US10506366

    申请日：2003-02-28

    申请人： Michele Orlando ,  Jurgen Hemberger ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Michele Orlando ,  Jurgen Hemberger ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： C08B31/00 ,  C08B31/02 ,  C08B31/18 ,  C07K1/00 ,  C07K17/00 ,  A61K31/715 ,  C08B33/00 ,  C08B35/00

    CPC分类号： A61K47/61

    摘要： The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及将低分子量物质与淀粉衍生的改性多糖结合的方法。 改性多糖和低分子量物质之间的结合相互作用是基于共价键，其是由该醛的化学反应引起的末端醛基或改性多糖分子的官能团之间的偶联反应的结果 基团和与该醛基反应的低分子量物质的官能团或与所得多糖分子的官能团反应的官能团。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联方法中形成的缀合物以及所述缀合物和组合物用于预防或治疗人或动物体的用途。

    Coupling proteins to a modified polysaccharide
    2.
    发明授权
    Coupling proteins to a modified polysaccharide 有权
    将蛋白质偶联至修饰的多糖

    公开(公告)号：US08916518B2

    公开(公告)日：2014-12-23

    申请号：US12473462

    申请日：2009-05-28

    申请人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C08B31/00 ,  A61K47/48 ,  C08H1/00 ,  C08B31/18

    CPC分类号： C08B31/185 ,  A61K47/61 ,  C08B31/00 ,  C08B31/18 ,  C08H1/00

    摘要： The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及将蛋白质与淀粉衍生的改性多糖偶联的方法。 改性多糖和蛋白质之间的结合相互作用是基于共价键，其是由该醛基的化学反应引起的末端醛基或改性多糖分子的官能团之间的偶联反应的结果， 与醛基反应的蛋白质组或与所得多糖分子的官能团反应的蛋白质组。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联过程中形成的缀合物以及用于预防或治疗人或动物体的缀合物和组合物的用途。

    Coupling Proteins to a Modified Polysaccharide
    3.
    发明申请
    Coupling Proteins to a Modified Polysaccharide 有权
    将蛋白质偶联到改性多糖

    公开(公告)号：US20090233847A1

    公开(公告)日：2009-09-17

    申请号：US12473462

    申请日：2009-05-28

    申请人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： C08B31/185 ,  A61K47/61 ,  C08B31/00 ,  C08B31/18 ,  C08H1/00

    摘要： The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及将蛋白质与淀粉衍生的改性多糖偶联的方法。 改性多糖和蛋白质之间的结合相互作用是基于共价键，其是由该醛基的化学反应引起的末端醛基或改性多糖分子的官能团之间的偶联反应的结果， 与醛基反应的蛋白质组或与所得多糖分子的官能团反应的蛋白质组。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联过程中形成的缀合物以及用于预防或治疗人或动物体的缀合物和组合物的用途。

    Coupling Low-Molecular Substances To A Modified Polysaccharide
    4.
    发明申请
    Coupling Low-Molecular Substances To A Modified Polysaccharide 审中-公开
    将低分子量物质偶联至改性多糖

    公开(公告)号：US20120259107A1

    公开(公告)日：2012-10-11

    申请号：US13494540

    申请日：2012-06-12

    申请人： Michele Orlando ,  Jurgen Hemberger ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Michele Orlando ,  Jurgen Hemberger ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： C08B31/00

    CPC分类号： A61K47/61

    摘要： The invention relates to a method for coupling low-molecular substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及一种将低分子物质与淀粉衍生的改性多糖结合的方法。 改性多糖与低分子物质之间的结合相互作用是基于共价键，其是由该醛基的化学反应导致的末端醛基或改性多糖分子的官能团之间的偶联反应的结果 以及与该醛基反应的低分子物质的官能团或与所得多糖分子的官能团反应的官能团。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联方法中形成的缀合物以及所述缀合物和组合物用于预防或治疗人或动物体的用途。

    Coupling proteins to a modified polysaccharide
    6.
    发明授权
    Coupling proteins to a modified polysaccharide 失效
    将蛋白质偶联至修饰的多糖

    公开(公告)号：US07541328B2

    公开(公告)日：2009-06-02

    申请号：US10506367

    申请日：2003-02-28

    申请人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： A61K38/00 ,  C07K14/00 ,  C08B31/00

    CPC分类号： C08B31/185 ,  A61K47/61 ,  C08B31/00 ,  C08B31/18 ,  C08H1/00

    摘要： The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及将蛋白质与淀粉衍生的改性多糖偶联的方法。 改性多糖和蛋白质之间的结合相互作用是基于共价键，其是由该醛基的化学反应引起的末端醛基或改性多糖分子的官能团之间的偶联反应的结果， 与醛基反应的蛋白质组或与所得多糖分子的官能团反应的蛋白质组。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联过程中形成的缀合物以及用于预防或治疗人或动物体的缀合物和组合物的用途。