公开(公告)号：US10285943B2

公开(公告)日：2019-05-14

申请号：US13990278

申请日：2011-12-02

申请人： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Ryan Wagner ,  Aareet Krsna Ganesh Shermon ,  Abdel Rahman Elsayed ,  Juewen Liu

发明人： Steven Bloembergen ,  Ian J. McLennan ,  Nathan Jones ,  Ryan Wagner ,  Aareet Krsna Ganesh Shermon ,  Abdel Rahman Elsayed ,  Juewen Liu

IPC分类号： A61K9/14 ,  A61K9/51 ,  B82Y5/00 ,  C08B31/00 ,  A61K9/16 ,  C08B31/18 ,  C08B33/00 ,  C08B35/00 ,  A61K31/704 ,  A61K47/54 ,  A61K47/69 ,  A61K47/36

摘要： A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

公开(公告)号：US09790351B2

公开(公告)日：2017-10-17

申请号：US13046762

申请日：2011-03-13

申请人： Lajos Szente

发明人： Lajos Szente

IPC分类号： C08B3/00 ,  C08B5/00 ,  C08B7/00 ,  C08B13/00 ,  C08B9/00 ,  C08B31/00 ,  C08B33/00 ,  C08B30/18 ,  C08B37/16 ,  C08B35/00 ,  C08L5/16 ,  A23L29/30 ,  A23L27/00 ,  A23L33/10 ,  A23L33/20

CPC分类号： C08L5/16 ,  A23L27/75 ,  A23L29/35 ,  A23L33/10 ,  A23L33/20 ,  A23V2002/00 ,  C08B37/0015 ,  A23V2250/5114 ,  A23V2200/332 ,  A23V2250/0612 ,  A23V2250/0644 ,  A23V2250/306

摘要： A fat-binding composition contains an inclusion complex with a host molecule and a guest molecule. The guest molecule includes one or more amino acids, vitamins, flavorants or related compounds, rutin, betanin, derivatives thereof, and mixtures thereof. The fat-binding composition may be in the form of a tablet or powder, for example, and may be incorporated into a food or beverage product. If in the form of a powder or tablet, the composition may optionally contain a carbonation-forming component and may be dissolved in carbonated or non-carbonated water. The fat-binding composition may also be employed in a method for binding fat ingested by an animal which includes having the animal ingest the composition, or a food or beverage product containing the same.

公开(公告)号：US08153783B2

公开(公告)日：2012-04-10

申请号：US12906710

申请日：2010-10-18

申请人： Rolf Muller ,  Federico Innerebner ,  Paul Smith ,  Theo A. Tervoort

发明人： Rolf Muller ,  Federico Innerebner ,  Paul Smith ,  Theo A. Tervoort

IPC分类号： C07H1/00 ,  C07H3/00 ,  C08B37/00 ,  C08B31/00 ,  C08B33/00 ,  C08B35/00

CPC分类号： C08L3/02 ,  A61J3/077 ,  A61K9/4816 ,  A61K9/5036 ,  C08B31/003 ,  C08L2666/02

摘要： The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.

摘要翻译： 具有高网络密度，高固体度，低溶胀度和显示减少的吸水性的多糖网络，特别是淀粉网络的生产，尤其是在可生物降解的塑料领域。

公开(公告)号：US07989616B2

公开(公告)日：2011-08-02

申请号：US11910896

申请日：2006-04-07

申请人： Stephan Soyka ,  Claus Frohberg

发明人： Stephan Soyka ,  Claus Frohberg

IPC分类号： C08B31/00 ,  C08B33/00 ,  C12N5/04

CPC分类号： C12N15/8245 ,  A23L29/212 ,  A23L29/219 ,  A23V2002/00 ,  C08B30/048 ,  C08B31/00 ,  A23V2300/21

摘要： This invention relates to modified starches having an elevated content of phosphate and an elevated content of amylose.

摘要翻译： 本发明涉及具有升高的磷酸盐含量和升高的直链淀粉含量的改性淀粉。

公开(公告)号：US07815893B2

公开(公告)日：2010-10-19

申请号：US11077906

申请日：2005-03-11

申请人： Norbert Zander ,  Harald S. Conradt ,  Wolfram Eichner

发明人： Norbert Zander ,  Harald S. Conradt ,  Wolfram Eichner

IPC分类号： A61K51/00 ,  A61K38/00 ,  A61K47/00 ,  A61M36/14 ,  A01N37/18 ,  A01N25/00 ,  C08B31/00 ,  C08B33/00 ,  C08B35/00

CPC分类号： C08B31/12 ,  A61K9/0021 ,  A61K38/00 ,  A61K47/61 ,  C07K14/505 ,  C07K14/53 ,  C07K14/5412 ,  C07K14/55 ,  C07K14/56 ,  C07K14/565 ,  C07K17/10 ,  C08B31/00 ,  C08B31/006 ,  C08B31/08 ,  C08B31/185 ,  C08H1/00

摘要： The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II) R′NH—R″ (II) wherein R1-R2 and R3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R′ or R″ or R′ and R″ comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.

摘要翻译： 本发明涉及一种生产羟烷基淀粉衍生物的方法，包括使式（I）的羟烷基淀粉在其还原末端反应，其在所述反应之前未被氧化，与式（II）化合物R'NH-R“（ II）其中R 1 -R 2和R 3独立地为氢或直链或支链羟烷基，并且其中R'或R“或R”和R“包含至少一个能够与至少一种其它化合物反应的官能团X 在（I）和（II）的反应之前或之后，以及通过所述方法得到的羟烷基淀粉衍生物，以及包含所述羟烷基淀粉衍生物的药物组合物。

公开(公告)号：US07524379B2

公开(公告)日：2009-04-28

申请号：US10738745

申请日：2003-12-17

申请人： Valerie Ann Bailey ,  Larry Neil Mackey ,  Paul Dennis Trokhan

发明人： Valerie Ann Bailey ,  Larry Neil Mackey ,  Paul Dennis Trokhan

IPC分类号： C13F3/00 ,  C08B31/00 ,  C08B33/00 ,  C08G61/02 ,  C08J3/00 ,  C08K7/00 ,  C08L3/00 ,  C08L89/00 ,  D21H19/54 ,  A23B7/10 ,  A23F3/00 ,  A23K1/00 ,  A23L1/05 ,  A23L1/22 ,  A23L1/216 ,  A23L1/40 ,  A23L1/238 ,  A21D10/00 ,  A21D13/00

CPC分类号： D01F8/10 ,  A61L15/28 ,  C08J5/18 ,  C08J2303/02 ,  C08L3/02 ,  C08L3/12 ,  D01F9/00 ,  Y10T428/24124 ,  Y10T428/249924 ,  Y10T428/268 ,  Y10T428/269 ,  Y10T428/2857 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2929 ,  Y10T428/298 ,  Y10T442/3146 ,  Y10T442/3171 ,  Y10T442/60 ,  Y10T442/637 ,  Y10T442/642 ,  Y10T442/643 ,  Y10T442/68 ,  Y10T442/681 ,  Y10T442/697 ,  Y10T442/698 ,  Y10T442/699 ,  A61L15/42 ,  A61L15/20 ,  C08L2666/02

摘要： The present invention relates to a starch composition comprising starch, a polymer that is substantially compatible with starch and has a weight-average molecular weight of at least 500,000 such that the polymer forms effective entanglements or associations with neighboring starch molecules, and preferably at least one additive to improve melt flow and melt processability. The additive may be a hydroxyl plasticizer, a hydroxyl-free plasticizer, a diluent, or mixtures thereof. The composition is melt processable on conventional thermoplastic equipment. The composition is especially suitable for uniaxial and biaxial extensional processes to make fibers, films, foams and like products.

摘要翻译： 本发明涉及包含淀粉的淀粉组合物，该淀粉基本上与淀粉相容并且具有至少500,000的重均分子量，使得聚合物与相邻的淀粉分子形成有效的缠结或缔合，优选至少一种 添加剂以改善熔体流动和熔融加工性能。 添加剂可以是羟基增塑剂，不含羟基的增塑剂，稀释剂或其混合物。 该组合物可在常规热塑性设备上熔融加工。 该组合物特别适用于制造纤维，薄膜，泡沫等产品的单轴和双轴拉伸工艺。

公开(公告)号：US07285661B2

公开(公告)日：2007-10-23

申请号：US10504892

申请日：2003-02-20

申请人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

发明人： Klaus Sommermeyer ,  Norbert Zander ,  Ronald Frank ,  Harald Conradt

IPC分类号： C08B31/00 ,  C08B33/00 ,  C08B35/00 ,  C07H5/04

CPC分类号： C08B31/00 ,  A61K47/61

摘要： The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R″ represents a straight-chain or branched alkyl group, aryl group or aralkyl group, and; R—CO— represents an oxidized substituted or unsubstituted starch radical that is oxidized on the reducing terminal group to form a carboxylic acid. Starch derivatives of formula (I) can selectively couple to active substances containing SH groups and have a prolonged half-life period in the human body. The invention also relates to coupling products of compound (I) with active substances, to methods for the production thereof, and to their use as medicaments

摘要翻译： 本发明涉及式（I）的淀粉衍生物，其中：X表示溴或碘原子; R“表示直链或支链烷基，芳基或芳烷基， R-CO-代表在还原端基上被氧化形成羧酸的氧化的取代或未取代的淀粉基团。 式（I）的淀粉衍生物可以选择性地偶联到含有SH基团的活性物质中，并且在人体中具有延长的半衰期。 本发明还涉及化合物（I）与活性物质的偶联产物，其制备方法及其作为药物的用途

公开(公告)号：US20070196437A1

公开(公告)日：2007-08-23

申请号：US11567680

申请日：2006-12-06

申请人： BRUCE HAMAKER ,  MAHESH VENKATACHALAM ,  GENYI ZHANG ,  ALI KESHAVARZIAN ,  DEVIN ROSE

发明人： BRUCE HAMAKER ,  MAHESH VENKATACHALAM ,  GENYI ZHANG ,  ALI KESHAVARZIAN ,  DEVIN ROSE

IPC分类号： A61K47/00 ,  A61K31/718 ,  C08B33/00

CPC分类号： A61K31/718 ,  A23L1/308 ,  A23L33/21 ,  A61K9/1652 ,  C08L3/02 ,  C08L5/04 ,  C08L5/06 ,  C08L2666/26

摘要： Compositions which provide slowly digestible starch and a source of fermentable dietary fiber. Microparticles in which starch is entrapped in a crosslinked matrix to provide dietary benefit. Such microparticles are used to deliver glucose to targeted regions in the small intestine for beneficial physiological effects, and fermentable dietary fiber to the colon to improve colon health and to treat diseases of the colon. Microparticles can be employed to selectively deliver fermentable dietary fiber to targeted portions of the colon. A method for making the microparticles is provided as well as methods for using the microparticles for controlled digestion of starch on ingestion in the small intestine and methods for using the microparticles to deliver dietary fiber. The microparticles with entrapped starch provide a low glycemic index and extended glucose release in food products and food ingredients. The microparticles with entrapped starch can, in particular, be used as an ingredient in foods that are to be cooked.

摘要翻译： 提供缓慢消化淀粉和可发酵膳食纤维来源的组合物。 将淀粉包埋在交联基质中以提供饮食益处的微粒。 这种微粒用于将葡萄糖输送到小肠中的目标区域以获得有益的生理作用，并将可发酵的膳食纤维输送到结肠以改善结肠健康并治疗结肠疾病。 微粒可用于选择性地将可发酵膳食纤维递送至结肠的目标部分。 提供了制备微粒的方法以及在小肠中摄取淀粉受控消化微粒的方法和使用该微粒来递送膳食纤维的方法。 具有包埋淀粉的微粒提供低的血糖指数，并延长食品和食品成分中的葡萄糖释放。 具有捕获的淀粉的微粒特别可以用作待烹饪的食品中的成分。

公开(公告)号：US06864063B2

公开(公告)日：2005-03-08

申请号：US10115347

申请日：2002-04-03

申请人： Gerrit Jan Willem Euverink ,  Doede Jacob Binnema

发明人： Gerrit Jan Willem Euverink ,  Doede Jacob Binnema

IPC分类号： A23L29/20 ,  B01J13/00 ,  C08B30/00 ,  C08B31/00 ,  C08J3/075 ,  C08L101/14 ,  C12P19/00 ,  C12Q1/48 ,  C08B33/00

CPC分类号： B01J13/0065

摘要： The invention relates to the use of modified starch obtainable by treating amylose containing starch in aqueous medium with an enzyme from the group of the α-1,4-α-1,4-glucosyl transferases (EC 2.4.1.25) or an enzyme the activity of which corresponds to that of enzymes from the group just mentioned, as an agent for forming a thermoreversible gel. The invention also relates to products in the form of a thermoreversible gel having as gel-forming substance a modified starch as defined. The invention further relates to the use of a modified starch as defined in the form of an aqueous solution.

摘要翻译： 本发明涉及使用通过在水性介质中用含有α-1,4-α-1,4-葡糖基转移酶（EC 2.4.1.25）的酶的酶处理直链淀粉而得到的改性淀粉或酶 其活性对应于刚刚提到的酶的活性，作为形成热可逆凝胶的试剂。 本发明还涉及具有如定义的改性淀粉作为凝胶形成物质的热可逆凝胶形式的产品。 本发明还涉及如水溶液形式所定义的改性淀粉的用途。

公开(公告)号：US6031085A

公开(公告)日：2000-02-29

申请号：US58888

申请日：1998-04-13

申请人： John F. Robyt ,  Rupendra Mukerjea

发明人： John F. Robyt ,  Rupendra Mukerjea

IPC分类号： C07H3/04 ,  C07H5/10 ,  C08B11/00 ,  C08B15/00 ,  C08B33/00 ,  C08B37/00 ,  C08B33/04 ,  C08B35/04 ,  C08B37/08

CPC分类号： C07H3/04 ,  C07H5/10 ,  C08B11/00 ,  C08B15/00 ,  C08B33/00

摘要： Reaction at the interface of an organic solution containing an acidic reactant and an aqueous alkaline solution containing nonreducing carbohydrates such as sucrose, sugar alcohols, cyclodextrins, and polysaccharides imparts a specificity to the reaction for one or more of the primary alcohol groups of the carbohydrate reactant. The resulting activated, nonreducing carbohydrate intermediate can then be converted to a series of substantially pure, low molecular weight reaction products, including a sucrose trimer and dianhydrosucrose, and to a series of substantially pure, higher molecular weight reaction products, including 6-O-sucro cyclodextrins and poly-6-O-sucro amylose.

摘要翻译： 在含有酸性反应物的有机溶液和含有非还原性碳水化合物如蔗糖，糖醇，环糊精和多糖的碱性水溶液的界面处的反应赋予碳水化合物反应物的一个或多个伯醇基团的反应特异性 。 然后将所得活化的非还原性碳水化合物中间体转化为一系列基本上纯的低分子量反应产物，包括蔗糖三聚体和二氢蔗糖，以及一系列基本上纯的较高分子量的反应产物，包括6-O- 蔗糖环糊精和聚-6-O-琥珀酸直链淀粉。