公开(公告)号：US12121560B2

公开(公告)日：2024-10-22

申请号：US17522570

申请日：2021-11-09

申请人： TissueGen, Inc.

发明人： Paul R. Sood ,  Alpeshkumar P. Patel ,  Jennifer Seifert ,  Ryszard Zarzycki

IPC分类号： A61K38/00 ,  C08B37/00 ,  C08B37/02 ,  C08H1/00 ,  C08H1/06 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04 ,  C08L5/08 ,  C08L5/12 ,  C08L89/00 ,  C08L89/06

CPC分类号： A61K38/00 ,  C08B37/0006 ,  C08B37/0021 ,  C08B37/0084 ,  C08H1/00 ,  C08H1/06 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04 ,  C08L5/08 ,  C08L5/12 ,  C08L89/00 ,  C08L89/06

摘要： A liquid ink composition includes a liquid phase and particles suspended in the liquid phase, the particles containing a target pharmaceutical or biological agent. The biological activity of the target pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase. The liquid phase is capable of solidifying via a solidification process.

公开(公告)号：US20230357514A1

公开(公告)日：2023-11-09

申请号：US18311419

申请日：2023-05-03

申请人： UES, Inc.

发明人： Sanaz Farajollahi ,  Patrick B. Dennis ,  Rajesh R. Naik ,  Joseph M. Slocik ,  Nancy Kelley-Loughnane

IPC分类号： C08H1/00 ,  C09K17/32 ,  C02F1/28 ,  C07K14/435 ,  B09C1/08

CPC分类号： C08H1/00 ,  C09K17/32 ,  C02F1/285 ,  C07K14/43536 ,  B09C1/08 ,  C02F2103/06

摘要： A polyelectrolyte-surfactant complex, a method of removing a toxic substance from contaminated soil or contaminated groundwater using a polyelectrolyte-surfactant complex and a method of making a polyelectrolyte-surfactant complex. The polyelectrolyte-surfactant complex is made from a complexated recombinant intrinsically disordered protein that has been electrostatically conjugated to an anionic surfactant to provide enhanced liquid-liquid phase separation properties.

公开(公告)号：US20190249046A1

公开(公告)日：2019-08-15

申请号：US16393909

申请日：2019-04-24

申请人： TEREOS STARCH AND SWEETENERS BELGIUM ,  UNIVERSITE DE LORRAINE

发明人： Antonio PIZZI ,  Marie-Christine LAGEL ,  Andreas REDL

IPC分类号： C09J161/06 ,  C08J9/00 ,  C08H1/00 ,  C09J189/00 ,  C08L89/00 ,  C08L97/02 ,  C08L61/06

CPC分类号： C09J161/06 ,  B27N3/002 ,  B27N3/02 ,  B27N3/04 ,  C08H1/00 ,  C08J9/0061 ,  C08J2205/10 ,  C08J2361/10 ,  C08J2489/00 ,  C08K5/103 ,  C08K5/175 ,  C08L61/06 ,  C08L89/00 ,  C08L97/02 ,  C09J189/00

摘要： A composition based on phenolic resin comprising at least one phenolic resin, a vegetable protein hydrolysate, preferentially a wheat gluten hydrolysate, and an agent for accelerating curing, and also to the process for the production thereof.

公开(公告)号：US20180200411A1

公开(公告)日：2018-07-19

申请号：US15907417

申请日：2018-02-28

申请人： DermaGenesis, LLC

发明人： Jess Bills ,  Derek Cox ,  David Tumey

IPC分类号： A61L27/60 ,  A61L27/56 ,  C08H1/00 ,  A61L27/26 ,  F26B5/06

CPC分类号： A61L27/60 ,  A61L27/20 ,  A61L27/26 ,  A61L27/362 ,  A61L27/3633 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3813 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2430/02 ,  A61L2430/34 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08H1/00 ,  F26B5/06

摘要： For making a matrix useable in a wound, matrix construction methods are provided, in which a slurry is formulated and then lyophilized. Usage of collagen and chondroitin sulfate (C6S) in the slurry is favored.

公开(公告)号：US20180170977A1

公开(公告)日：2018-06-21

申请号：US15739057

申请日：2016-06-23

申请人： Spiber Technologies AB

发明人： My Hedhammar

IPC分类号： C07K14/435 ,  C12N15/62 ,  C12N5/00 ,  C08H1/00

CPC分类号： C07K14/43518 ,  C07K16/2839 ,  C07K2319/70 ,  C08H1/00 ,  C12N5/0068 ,  C12N15/62 ,  C12N2533/50

摘要： A recombinant fusion protein is comprising a spider silk fragment and a cyclic RGD cell-binding motif with selectivity for integrins, such as for α5β1 integrins. The fusion protein is useful as a cell scaffold material and for the cultivation of cells displaying integrins on their cell surface.

公开(公告)号：US20180043030A1

公开(公告)日：2018-02-15

申请号：US15549787

申请日：2016-02-09

申请人： MOSAIC BIOSCIENCES, INC.

发明人： Alexei V. KAZANTSEV ,  Peter D. MARINER ,  Martin STANTON

IPC分类号： A61K47/60 ,  A61K38/08 ,  A61K38/39 ,  A61K38/10 ,  A61K9/06 ,  C08G65/334

CPC分类号： A61K47/60 ,  A61K9/06 ,  A61K38/08 ,  A61K38/10 ,  A61K38/39 ,  C07K1/1077 ,  C07K14/78 ,  C08B37/0069 ,  C08B37/0075 ,  C08G65/3342 ,  C08G75/045 ,  C08G75/12 ,  C08G81/00 ,  C08G2210/00 ,  C08G2650/04 ,  C08G2650/16 ,  C08G2650/20 ,  C08H1/00 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/16 ,  C08J2371/02 ,  C08J2389/00 ,  C08L101/16 ,  C12N9/2462 ,  C12Y302/01017

摘要： Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.

公开(公告)号：US09816019B2

公开(公告)日：2017-11-14

申请号：US15205214

申请日：2016-07-08

申请人： Evertree

发明人： Anthony A. Parker ,  Joseph J. Marcinko

IPC分类号： C08L97/02 ,  C09J189/00 ,  C09J175/04 ,  C08H1/00 ,  C08G18/40 ,  C08G18/64 ,  B27N3/00 ,  B27N3/02 ,  C09J5/00 ,  C08L23/08

CPC分类号： C09J189/00 ,  B27N3/002 ,  B27N3/02 ,  C08G18/4081 ,  C08G18/6446 ,  C08H1/00 ,  C08L23/0853 ,  C08L97/02 ,  C08L2666/06 ,  C09J5/00 ,  C09J175/04 ,  C09J2489/00 ,  Y10T428/31634 ,  Y10T428/31703 ,  Y10T428/31725 ,  Y10T428/31971 ,  Y10T428/31982 ,  C08L2666/02

摘要： The invention provides protein adhesives and methods of making and using such adhesives. The protein adhesives contain ground plant meal or an isolated polypeptide composition obtained from plant biomass.

公开(公告)号：US09783678B2

公开(公告)日：2017-10-10

申请号：US15005382

申请日：2016-01-25

申请人： The Penn State Research Foundation ,  President and Fellows of Harvard College

发明人： Manish Kumar ,  Thomas Walz

IPC分类号： C08L89/00 ,  B01D67/00 ,  B01D71/74 ,  B01D71/80 ,  C08H1/00

CPC分类号： C08L89/00 ,  B01D67/0009 ,  B01D71/74 ,  B01D71/80 ,  B01D2323/12 ,  C08H1/00 ,  C08L53/00

摘要： Embodiments of the invention provide methods for preparing high density membrane protein membranes by slow, controlled removal of detergent from mixtures of detergent, block copolymers and membrane protein mixtures. Membranes created by this method are also provided. The structure of these membranes may be varied by varying the amount of membrane protein.

公开(公告)号：US20170204161A1

公开(公告)日：2017-07-20

申请号：US15362030

申请日：2016-11-28

申请人： The Chinese University of Hong Kong

发明人： Liming BIAN ,  Yang XU ,  Kongchang WEI ,  Pengchao ZHAO

IPC分类号： C07K14/78 ,  C09J189/00

CPC分类号： C07K14/78 ,  C08H1/00 ,  C09J189/00

摘要： The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to each other as well as to solid surface, including the making of adhesive materials such as hydrogels.

公开(公告)号：US09687583B2

公开(公告)日：2017-06-27

申请号：US14342392

申请日：2012-08-30

申请人： Oded Shoseyov ,  Shaul Lapidot ,  Amit Rivkin

发明人： Oded Shoseyov ,  Shaul Lapidot ,  Amit Rivkin

IPC分类号： A61L24/10 ,  C08J3/24 ,  C09J189/00 ,  C08B37/00 ,  C08H1/00 ,  C07K14/435

CPC分类号： A61L24/108 ,  A61L2430/06 ,  C07K14/43563 ,  C08B37/00 ,  C08H1/00 ,  C08J3/24 ,  C08J2300/16 ,  C09J189/00

摘要： Provided herein are polymers having the general formula I as defined herein, A-L-B  Formula I as well as crosslinked polymers having the general formula III: B′-L′-A′-A″-L″-B″  Formula III and methods of preparing the polymers, wherein A is a dihydroxyphenyl moiety; A′-A″ is a pair of crosslinked dihydroxyphenyl moieties; B, B′ and B″ are each a biopolymer; and L, L′ and L″ are each a linking moiety. Further provided are crosslinked adhesives prepared from the polymers, methods of generating same by oxidizing a polymer, and uses thereof. Further provided are kits comprising an adhesive and an oxidizing agent.