公开(公告)号：US09926580B2

公开(公告)日：2018-03-27

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66 ,  C12P7/22

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

公开(公告)号：US20190127773A1

公开(公告)日：2019-05-02

申请号：US16233392

申请日：2018-12-27

Applicant: KANEKA CORPORATION

Inventor： Wan Ying LEE ,  Yasuyuki Suzuki ,  Akihisa Kanda

IPC: C12P23/00 ,  B01J20/20 ,  B01J20/18 ,  B01D15/00 ,  B01J20/22

Abstract: A method of producing coenzyme Q10 includes contacting an extract from a coenzyme Q10-producing microorganism with an adsorbent (A) such that the adsorbent (A) adsorbs a component of the extract other than coenzyme Q10, and that coenzyme Q10 is obtained. The adsorbent (A) includes aluminum silicate at a content of 50% or more.

公开(公告)号：US20200208189A9

公开(公告)日：2020-07-02

申请号：US16233392

申请日：2018-12-27

Applicant: KANEKA CORPORATION

Inventor： Wan Ying LEE ,  Yasuyuki Suzuki ,  Akihisa Kanda

IPC: C12P23/00 ,  B01J20/20 ,  B01J20/18 ,  B01D15/00 ,  B01J20/22

Abstract: A method of producing coenzyme Q10 includes contacting an extract from a coenzyme Q10-producing microorganism with an adsorbent (A) such that the adsorbent (A) adsorbs a component of the extract other than coenzyme Q10, and that coenzyme Q10 is obtained. The adsorbent (A) includes aluminum silicate at a content of 50% or more.

公开(公告)号：US20160304915A1

公开(公告)日：2016-10-20

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

Abstract translation: 一种在工业规模上生产氧化型辅酶Q10的方法，包括培养选自Rhodobacter属，Saitoella属，粟酒裂殖酵母属和Trichosporon属的还原型辅酶Q10产生微生物，以获得含有还原型 辅酶Q10在整个辅酶Q10中的比例不小于70摩尔％; 和（a）将由此得到的还原型辅酶Q10氧化成氧化型辅酶Q10，然后用有机溶剂萃取氧化型辅酶Q10; 或（b）用有机溶剂萃取还原型辅酶Q10，将提取的还原型辅酶Q10氧化成氧化型辅酶Q10。