公开(公告)号：US09926580B2

公开(公告)日：2018-03-27

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66 ,  C12P7/22

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

公开(公告)号：US20160304915A1

公开(公告)日：2016-10-20

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

Abstract translation: 一种在工业规模上生产氧化型辅酶Q10的方法，包括培养选自Rhodobacter属，Saitoella属，粟酒裂殖酵母属和Trichosporon属的还原型辅酶Q10产生微生物，以获得含有还原型 辅酶Q10在整个辅酶Q10中的比例不小于70摩尔％; 和（a）将由此得到的还原型辅酶Q10氧化成氧化型辅酶Q10，然后用有机溶剂萃取氧化型辅酶Q10; 或（b）用有机溶剂萃取还原型辅酶Q10，将提取的还原型辅酶Q10氧化成氧化型辅酶Q10。