公开(公告)号：US20180271930A1

公开(公告)日：2018-09-27

申请号：US16003975

申请日：2018-06-08

Applicant: Kaneka Corporation

Inventor： Kazuyoshi Yajima ,  Kan Sato

IPC: A61K38/06 ,  A23K20/147 ,  A23K50/75 ,  A61K9/00

CPC classification number: A61K38/063 ,  A23K20/147 ,  A23K50/75 ,  A61K9/0056

Abstract: A method for raising poultry includes feeding poultry with a feed comprising oxidized glutathione during a period between hatching and 24 to 168 hours after the hatching.

公开(公告)号：US09926580B2

公开(公告)日：2018-03-27

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66 ,  C12P7/22

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

公开(公告)号：US20160304915A1

公开(公告)日：2016-10-20

申请号：US15076025

申请日：2016-03-21

Applicant: KANEKA CORPORATION

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P7/66

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.

Abstract translation: 一种在工业规模上生产氧化型辅酶Q10的方法，包括培养选自Rhodobacter属，Saitoella属，粟酒裂殖酵母属和Trichosporon属的还原型辅酶Q10产生微生物，以获得含有还原型 辅酶Q10在整个辅酶Q10中的比例不小于70摩尔％; 和（a）将由此得到的还原型辅酶Q10氧化成氧化型辅酶Q10，然后用有机溶剂萃取氧化型辅酶Q10; 或（b）用有机溶剂萃取还原型辅酶Q10，将提取的还原型辅酶Q10氧化成氧化型辅酶Q10。

公开(公告)号：US08889389B2

公开(公告)日：2014-11-18

申请号：US14066231

申请日：2013-10-29

Applicant: Kaneka Corporation

Inventor： Akihiko Kosugi ,  Kazuyoshi Yajima

IPC: C12P21/06 ,  C12N11/14 ,  C12N15/00 ,  C12N1/20 ,  C12P21/02 ,  C07K16/12 ,  C07K14/31

CPC classification number: C07K16/1271 ,  C07K14/31 ,  C12P21/02

Abstract: The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production of a protein A-like protein using a genetic recombination technique and however, their low productivity has been a big cause of high cost. Thus, it has been desired strongly to immediately establish a technique enabling the inexpensive, large-scale production of a protein A-like protein using recombinant DNA techniques other than Escherichia coli and Bacillus subtilis. The present invention provides a process for producing a protein A-like protein in large amounts, for example, a process comprising allowing a recombinant Brevibacillus genus bacterium to express and secrete the protein in large amounts into a culture solution and separating and collecting the accumulated protein A-like protein from the culture solution.

Abstract translation: 本发明涉及用于生产蛋白质A样蛋白质的有效和经济的方法。 宿主如大肠杆菌和枯草芽孢杆菌已经用于使用遗传重组技术生产蛋白质A样蛋白质，然而，它们的低生产率已成为高成本的主要原因。 因此，迫切需要立即建立一种能够使用除大肠杆菌和枯草芽孢杆菌之外的重组DNA技术廉价大规模生产蛋白A样蛋白的技术。 本发明提供了大量生产蛋白质A样蛋白质的方法，例如包括使重组短杆菌属细菌大量表达和分泌蛋白质并分离和收集积累的蛋白质的方法 来自培养液的A样蛋白质。