公开(公告)号：US10227586B2

公开(公告)日：2019-03-12

申请号：US15491154

申请日：2017-04-19

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Younghoon Lee ,  Won Kyong Kim ,  Geunu Bak ,  Hongmarn Park ,  Jee Soo Choi ,  Shinae Suk ,  Ji Young Lee ,  Yeongseong Yoon

IPC: C12N15/10

Abstract: The present invention relates to an artificial ncRNA expression library and a method for preparing the same, and particularly the present invention relates to a library securing the stability of the artificial ncRNA by cloning random fragmented DNA that whole genome DNA of E. coli is randomly fragmented to a middle of RNA scaffold having a double stem-loop and a method for preparing the same.

公开(公告)号：US09834768B2

公开(公告)日：2017-12-05

申请号：US14855612

申请日：2015-09-16

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Younghoon Lee ,  Geunu Bak ,  Hongmarn Park ,  Jee Soo Choi ,  Won Kyeong Kim ,  Shinae Suk ,  Ji Young Lee ,  Yeongseong Yoon

IPC: C07H21/02 ,  G01N33/554 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/531 ,  C12N2330/51

Abstract: A nucleic acid molecule comprising a stem-loop structure, a nucleic acid complex comprising the nucleic acid molecule, a composition for delivering a target recognition sequence, and the composition comprising the nucleic acid complex. An artificial small ribonucleic acid of the stem-loop structure stably maintains single-strandedness of a target recognition sequence which interacts with a nucleic acid of interest for a gene of interest of a prokaryote, thereby providing a nucleic acid complex for effective silencing of the gene of interest.

公开(公告)号：US09512235B2

公开(公告)日：2016-12-06

申请号：US14302559

申请日：2014-06-12

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Younghoon Lee ,  Euihan Jung ,  Jung Min Lee ,  Insoo Park ,  Hyo Jeong Hong

IPC: C07K16/18 ,  G01N33/53 ,  C07K16/44 ,  C12Q1/68

CPC classification number: C07K16/44 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/92 ,  C12Q1/6804

Abstract: The present invention relates to an antibody being capable of binding specifically to BC200 RNA or its antigen binding fragment, a polynucleotide of encoding the antibody or its antigen binding fragment, a composition, kit and method for detecting BC200 RNA in a sample using the antibody or its antigen binding fragment, and a composition for diagnosis, prevention or treatment of BC200 RNA-associated diseases including the antibody or its antigen binding fragment.

Abstract translation: 本发明涉及能够特异性结合BC200RNA或其抗原结合片段的抗体，编码抗体或其抗原结合片段的多核苷酸，用于使用抗体检测样品中BC200 RNA的组合物，试剂盒和方法，或 其抗原结合片段和用于诊断，预防或治疗包括抗体或其抗原结合片段的BC200 RNA相关疾病的组合物。

公开(公告)号：US20160312175A1

公开(公告)日：2016-10-27

申请号：US14854583

申请日：2015-09-15

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Insung Choi ,  Ji Hun Park ,  Younghoon Lee ,  Kyunghwan Kim ,  Juno Lee

IPC: C12N1/04 ,  C12N5/00

CPC classification number: C12N1/04 ,  C12N1/18 ,  C12N5/0006 ,  C12N2533/10

Abstract: The present invention relates to a cell coating method using a compound including a gallate group, and a lanthanoid metal salt or transition metal salt. According to the cell coating method of the present invention, a cell having a surface coated with a nanoshell prepared by this method is stably protected from external environmental stimulus such as light irradiation, and silver nanoparticles, and the coating is degraded as necessary without damaging the cell.

Abstract translation: 本发明涉及使用包含没食子酸酯基的化合物和镧系金属盐或过渡金属盐的细胞包被方法。 根据本发明的电池涂布方法，具有通过该方法制备的具有纳米壳的表面的电池被稳定地保护免受外部环境刺激如光照射和银纳米颗粒，并且涂层根据需要降解，而不损害 细胞。