公开(公告)号：US11291726B2

公开(公告)日：2022-04-05

申请号：US16395236

申请日：2019-04-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon Kim ,  Youngsun Kim ,  Keunsoo Jeong ,  Gayoung Kim

IPC: A61K41/00 ,  A61N5/06 ,  C09B23/08 ,  C09B67/46 ,  C09B67/54 ,  C09B67/02

Abstract: The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble salt of a near-infrared-absorbing dye, which comprises anions of the near-infrared-absorbing dye and metal cations capable of forming a precipitation product with the anions of the near-infrared-absorbing dye; and particles of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant.

公开(公告)号：US10814022B2

公开(公告)日：2020-10-27

申请号：US15581295

申请日：2017-04-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon Kim ,  Chang-Keun Lim ,  Jeong yun Heo ,  Keunsoo Jeong

IPC: A61K49/22 ,  A61K49/00 ,  G01N21/64 ,  A61K47/34

Abstract: The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.

公开(公告)号：US20180064832A1

公开(公告)日：2018-03-08

申请号：US15581295

申请日：2017-04-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon Kim ,  Chang-Keun Lim ,  Jeong yun Heo ,  Keunsoo Jeong

IPC: A61K49/22 ,  A61K47/34

CPC classification number: A61K49/226 ,  A61K47/34 ,  G01N21/64

Abstract: The present invention relates to a nanogel comprising a polyamine-based polymer cross-linked by oxamide bonds, a preparation method of the nanogel, a contrast agent for ultrasound imaging comprising the nanogel, a composition for ultrasound diagnosis of inflammatory diseases comprising the contrast agent, a preparation method of the contrast agent, and a method for providing information for diagnosis of inflammatory diseases using the composition for ultrasound diagnosis.