公开(公告)号：US20210269602A1

公开(公告)日：2021-09-02

申请号：US17095925

申请日：2020-11-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Youngmee JUNG ,  Justin Jihong CHUNG ,  Seung Hyuk IM

IPC: C08J3/03 ,  A61K9/107 ,  A61K47/34

Abstract: Provided are a method for producing a stereocomplex polylactic acid composite based on oil-in-water emulsion blending, a method for preparing a drug delivery composition using a stereocomplex polylactic acid composite produced by the production method, and a drug delivery composition prepared by the preparation method. The stereocomplex polylactic acid composite is produced using oil-in-water emulsion blending that has the advantages of simple process, short production time, and high stereocomplexation efficiency compared to existing methods such as solution blending, melt-blending, and supercritical fluid technology. In addition, the drug delivery composition is prepared using oil-in-water emulsion blending that allows the drug to be loaded into the polymer chains of the stereocomplex polylactic acid in a very easy and efficient manner and facilitates release of the drug at room temperature over a long period of time.

公开(公告)号：US20160045645A1

公开(公告)日：2016-02-18

申请号：US14514786

申请日：2014-10-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Youngmee JUNG ,  Jin Ik LIM

IPC: A61L31/12 ,  A61L31/06 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61L31/129 ,  A61L17/12 ,  A61L27/48 ,  A61L27/58 ,  A61L31/148 ,  C08L67/04

Abstract: Disclosed is a biodegradable polymer whose physical properties are improved by the presence of a stereocomplex organic filler. According to exemplary embodiments, the biodegradable polymer including a stereocomplex organic filler can find application in various fields, including biodegradable materials and medical materials, where conventional biodegradable polymers are difficult to use due to their inherent problems such as poor heat resistance and low strength. Also disclosed is a method for producing the biodegradable polymer.

Abstract translation: 公开了一种可通过立体络合物有机填料的存在改善其物理性能的可生物降解的聚合物。 根据示例性实施方案，包括立体络合物有机填料的可生物降解的聚合物可用于各种领域，包括可生物降解的材料和医疗材料，其中传统的可生物降解聚合物由于其耐热性差和强度低等固有问题而难以使用。 还公开了生物可降解聚合物的制造方法。