公开(公告)号：US20210381112A1

公开(公告)日：2021-12-09

申请号：US17338110

申请日：2021-06-03

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hojeong JEON ,  Seung Hoon UM ,  Jae Ho PARK ,  Justin Jihong CHUNG ,  Hyunseon SEO ,  Hyung-Seop HAN ,  Yu Chan KIM ,  Myoung-Ryul OK ,  Hyun Kwang SEOK

IPC: C23C26/00 ,  B23K26/122 ,  B23K26/352 ,  C01B25/32

Abstract: Provided is a method of forming an apatite coating, the method including immersing a substrate in an apatite-forming precursor solution including Ca2+ ions and PO43− ions, emitting a laser beam onto a surface of the substrate immersed in the precursor solution, and forming an apatite coating in a region exposed to the laser beam, wherein an output power of the laser beam is set within a range enabling the surface of the substrate to be melted.

公开(公告)号：US20210301241A1

公开(公告)日：2021-09-30

申请号：US17081723

申请日：2020-10-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Soo Hyun KIM ,  Justin Jihong CHUNG ,  Jin YOO ,  Tae Hee KIM

IPC: C12M1/00

Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity. The porous polymer membrane can be utilized in a platform for inducing stem cell differentiation, a lab-on-a-chip, a synthetic skin simulant platform, etc.

公开(公告)号：US20210269602A1

公开(公告)日：2021-09-02

申请号：US17095925

申请日：2020-11-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Youngmee JUNG ,  Justin Jihong CHUNG ,  Seung Hyuk IM

IPC: C08J3/03 ,  A61K9/107 ,  A61K47/34

Abstract: Provided are a method for producing a stereocomplex polylactic acid composite based on oil-in-water emulsion blending, a method for preparing a drug delivery composition using a stereocomplex polylactic acid composite produced by the production method, and a drug delivery composition prepared by the preparation method. The stereocomplex polylactic acid composite is produced using oil-in-water emulsion blending that has the advantages of simple process, short production time, and high stereocomplexation efficiency compared to existing methods such as solution blending, melt-blending, and supercritical fluid technology. In addition, the drug delivery composition is prepared using oil-in-water emulsion blending that allows the drug to be loaded into the polymer chains of the stereocomplex polylactic acid in a very easy and efficient manner and facilitates release of the drug at room temperature over a long period of time.