利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.031 秒)

    COMBINATION THERAPY
    4.
    发明申请
    COMBINATION THERAPY 有权
    组合治疗

    公开(公告)号：US20120148533A1

    公开(公告)日：2012-06-14

    申请号：US13313042

    申请日：2011-12-07

    申请人： Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    发明人： Kapil Dhingra ,  Brian Higgins ,  Kenneth Kolinsky ,  Richard J. Lee ,  Brian Lestini ,  Kathryn Packman ,  Fei Su

    IPC分类号： A61K38/21 ,  A61P35/00

    CPC分类号： A61K38/212 ,  A61K31/437 ,  A61K38/21 ,  A61K2300/00

    摘要： The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation.

    摘要翻译： 本发明涉及丙烷-1-磺酸{3- [5-（4-氯 - 苯基）-1H-吡咯并[2,3-b]吡啶-3-羰基-2,4-二氟 - 苯基] - 酰胺}或其药学上可接受的盐，以及用于治疗患有增殖性疾病，特别是实体瘤例如结肠直肠癌，黑素瘤和甲状腺癌的患者的干扰素。 特别地，本发明涉及这样的治疗，其中干扰素是聚乙二醇化干扰素α-2a，该病症是含有V600E b-Raf突变的黑素瘤。

    Combination bullet seating and factory crimp die
    6.
    发明授权
    Combination bullet seating and factory crimp die 失效
    组合子弹座椅和工厂压接模具

    公开(公告)号：US07703369B1

    公开(公告)日：2010-04-27

    申请号：US12366120

    申请日：2009-02-05

    申请人： Richard J. Lee

    发明人： Richard J. Lee

    IPC分类号： F42B33/00

    CPC分类号： F42B33/005 ,  F42B33/10

    摘要： A combination bullet seating and factory crimp die includes a collet closing die, a crimping collet, a die cap, a seating lock, a bullet depth adjustment screw and a trigger. The crimping collet is inserted into the collet closing die. The trigger is placed in the collet closing die. The bullet depth adjustment screw is threaded into the seating lock. The seating lock is inserted into the die cap. The seating lock includes a sear groove for receiving a C-ring sear. The collet closing die is threaded into the die cap. A bullet seater is retained in the seating lock. In use, a bullet on a mouth of a cartridge case is pushed into the crimping collet. The bullet seater seats the bullet. The trigger pushes the C-ring sear into the sear groove, which allows the mouth of the cartridge to be crimped without moving the bullet.

    摘要翻译： 组合子弹座和工厂压接模具包括夹头封闭模具，压接夹头，模具盖，座椅锁，子弹深度调节螺钉和触发器。 压接夹头插入夹头封闭模具中。 触发器放置在夹头闭合模具中。 子弹深度调节螺丝拧入座椅锁。 座椅锁被插入模具帽。 座椅锁包括一个用于接收C形圈扣的敲击槽。 夹头封闭模具被拧入模具盖。 座椅锁上保留有一个子弹座。 在使用中，将盒壳的口部上的子弹推入卷曲筒夹中。 子弹座位子弹。 触发器将C形圈扣件推入到冲洗槽中，这使得墨盒的嘴可以被压接而不移动子弹。

    Automatic bullet feeder
    7.
    发明授权
    Automatic bullet feeder 失效
    自动送料机

    公开(公告)号：US5763810A

    公开(公告)日：1998-06-09

    申请号：US682304

    申请日：1996-07-17

    申请人： Richard J. Lee

    发明人： Richard J. Lee

    IPC分类号： F42B33/00

    CPC分类号： F42B33/002

    摘要： A device for feeding bullets to an ammunition reloading press. A bullet guide member in the device has a vertical bore for allowing bullets to descend by gravity from a stack of bullets in a storage tube one at a time to a small platform. A feeder body is mounted for reciprocating vertically on the guide member and a shuttle is mounted for sliding horizontally relative to the feeder body between a retracted position on the body to a fully advanced position where the bullet picked up from the platform by grippers on the shuttle is aligned with a bullet seating tool and with an ammunition case that is moving upward with the ram of the press. Continuing upward movement of the ram causes the case to be pushed slightly onto the bullet and ultimately the mechanism that moves the shuttle out an in, the feeder body and shuttle rise so the bullet begins to enter the seating die. Continued upward movement of the ram causes the mouth of the bullet seating die to spread the gripping means apart so the bullet and case can continue freely into the die in which the bullet is seated. Reversal of the ram into a descending mode causes lowering of the shuttle and body of the shuttle can retract again for gripping a bullet which has settled on the platform when the shuttle was advancing.

    摘要翻译： 用于将子弹送到弹药重新装载机的装置。 装置中的子弹引导构件具有垂直孔，用于允许子弹通过重力从存储管中的一堆子弹一次一个地下降到小平台。 馈送器主体被安装成垂直地在引导构件上往复运动，并且安装梭子，用于相对于进给器本体在本体的缩回位置之间水平地滑动到完全前进的位置，在该完全前进位置，通过夹子在梭子上从该平台拾起的子弹 与一个子弹座椅工具和一个弹药箱与印刷机的压头向上移动对齐。 柱塞的继续向上运动导致壳体被稍微推入到子弹上，并且最终将使梭子移出的机构，进料器主体和梭子上升，使得子弹开始进入座模。 柱塞的继续向上运动导致子弹座模的口部将夹持装置分开扩展，使得子弹和壳体可以自由地继续进入子弹就位的模具中。 将冲头反转成下降模式导致梭子的下降，梭子的主体可以再次缩回，以夹紧当梭子前进时已经沉降在平台上的子弹。

    Powder measuring device for cartridge reloader
    10.
    发明授权
    Powder measuring device for cartridge reloader 失效
    墨盒重新装载机的粉末测量装置

    公开(公告)号：US4418606A

    公开(公告)日：1983-12-06

    申请号：US485148

    申请日：1983-04-15

    申请人： Richard J. Lee

    发明人： Richard J. Lee

    IPC分类号： F42B33/02

    CPC分类号： F42B33/0292

    摘要： A powder measuring device for use in connection with reloading cartridges has a powder transfer member supported for translating or, alternatively, rotating between a position where at least one cavity in the member is filled with powder from a hopper to another position wherein the powder is discharged through a tube to an empty cartridge. A cartridge to be reloaded is driven upwardly by a manually operated ram. The force for actuating the mechanism that drives the transport member is transmitted through the cartridge which means that unless a cartridge is positioned on the ram for receiving the powder the transport member will not be moved in response to operation of the ram and unintended discharge of powder will be prevented.

    摘要翻译： 用于与重新装载筒相关联使用的粉末测量装置具有粉末传送构件，该粉末传送构件被支撑用于在构件中的至少一个空腔填充有来自料斗的粉末到另一个位置的位置之间进行平移或可选地旋转， 通过管到一个空的墨盒。 要重新装载的药筒由手动操作的压头向上驱动。 用于致动驱动传送构件的机构的力被传递通过盒，这意味着除非筒被定位在用于接收粉末的柱塞上，否则传送构件将不会响应于冲头的操作而移动，并且意外排出粉末 将被阻止。