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    Focus information generating device and focus information generating method
    3.
    发明授权
    Focus information generating device and focus information generating method 失效
    焦点信息生成装置和焦点信息生成方法

    公开(公告)号：US08710412B2

    公开(公告)日：2014-04-29

    申请号：US13255637

    申请日：2010-03-01

    申请人： Koichiro Kishima ,  Yu Hirono ,  Takamichi Yamakoshi

    发明人： Koichiro Kishima ,  Yu Hirono ,  Takamichi Yamakoshi

    IPC分类号： G02B7/04 ,  G02B27/40 ,  G02B27/64

    CPC分类号： G02B21/241 ,  G02B21/245

    摘要： It is possible to generate image data of a biological tissue in a short time.A focus information generating device (2) receives a first reflected light beam (Lr1) split from a reflected light beam (Lr) and a second reflected light beam (Lr2) passing through a pin-hole plate (36). A signal processing unit (13) calculates a uniform reflectance (RE) representing a light amount ratio of the second reflected light beam (Lr2) to the first reflected light beam (Lr1) along with a sum signal (SS) and a difference signal (SD). An integrated control unit (11) detects a position (Z1) corresponding to a top surface (104A) of a cover glass (104) on the basis of the sum signal (SS) and the difference signal (SD) and detects a position (Z3) representing a biological tissue (102) on the basis of the sum signal (SS) and the uniform reflectance (RE). As a result, the integrated control unit (11) can calculate a cover distance (DM) from the top surface (104A) of the cover glass (104) to the biological tissue (102) in a pathology glass slide (100) on the basis of the positions (Z1) and (Z3).

    摘要翻译： 可以在短时间内生成生物组织的图像数据。 聚焦信息生成装置（2）接收从反射光束（Lr）分割的第一反射光束（Lr1）和穿过针孔板（36）的第二反射光束（Lr2）。 信号处理单元（13）计算表示第二反射光束（Lr2）与第一反射光束（Lr1）的光量比的均匀反射率（RE）以及和信号（SS）和差信号（ SD）。 综合控制单元（11）根据和信号（SS）和差分信号（SD）检测对应于玻璃罩（104）的顶面（104A）的位置（Z1），并检测位置 Z3）基于和信号（SS）和均匀反射率（RE）代表生物组织（102）。 结果，集成控制单元（11）可以计算从玻璃（104）的上表面（104A）到生物组织（102）的覆盖距离（DM）到病理玻璃载玻片（100）上的覆盖距离 位置（Z1）和（Z3）的基础。

    FOCUS INFORMATION GENERATING DEVICE AND FOCUS INFORMATION GENERATING METHOD
    4.
    发明申请
    FOCUS INFORMATION GENERATING DEVICE AND FOCUS INFORMATION GENERATING METHOD 失效
    聚焦信息生成装置和聚焦信息生成方法

    公开(公告)号：US20110315851A1

    公开(公告)日：2011-12-29

    申请号：US13255637

    申请日：2010-03-01

    申请人： Koichiro Kishima ,  Yu Hirono ,  Takamichi Yamakoshi

    发明人： Koichiro Kishima ,  Yu Hirono ,  Takamichi Yamakoshi

    IPC分类号： G02B27/40 ,  G02B21/36

    CPC分类号： G02B21/241 ,  G02B21/245

    摘要： It is possible to generate image data of a biological tissue in a short time.A focus information generating device (2) receives a first reflected light beam (Lr1) split from a reflected light beam (Lr) and a second reflected light beam (Lr2) passing through a pin-hole plate (36). A signal processing unit (13) calculates a uniform reflectance (RE) representing a light amount ratio of the second reflected light beam (Lr2) to the first reflected light beam (Lr1) along with a sum signal (SS) and a difference signal (SD). An integrated control unit (11) detects a position (Z1) corresponding to a top surface (104A) of a cover glass (104) on the basis of the sum signal (SS) and the difference signal (SD) and detects a position (Z3) representing a biological tissue (102) on the basis of the sum signal (SS) and the uniform reflectance (RE). As a result, the integrated control unit (11) can calculate a cover distance (DM) from the top surface (104A) of the cover glass (104) to the biological tissue (102) in a pathology glass slide (100) on the basis of the positions (Z1) and (Z3).

    摘要翻译： 可以在短时间内生成生物组织的图像数据。 聚焦信息生成装置（2）接收从反射光束（Lr）分割的第一反射光束（Lr1）和穿过针孔板（36）的第二反射光束（Lr2）。 信号处理单元（13）计算表示第二反射光束（Lr2）与第一反射光束（Lr1）的光量比的均匀反射率（RE）以及和信号（SS）和差信号（ SD）。 综合控制单元（11）根据和信号（SS）和差分信号（SD）检测对应于玻璃罩（104）的顶面（104A）的位置（Z1），并检测位置 Z3）基于和信号（SS）和均匀反射率（RE）代表生物组织（102）。 结果，集成控制单元（11）可以计算从玻璃（104）的上表面（104A）到生物组织（102）的覆盖距离（DM）到病理玻璃载玻片（100）上的覆盖距离 位置（Z1）和（Z3）的基础。

    Image acquisition apparatus and image acquisition method
    6.
    发明授权
    Image acquisition apparatus and image acquisition method 有权
    图像采集装置和图像采集方法

    公开(公告)号：US08553140B2

    公开(公告)日：2013-10-08

    申请号：US12850251

    申请日：2010-08-04

    申请人： Takamichi Yamakoshi ,  Koichiro Kishima

    发明人： Takamichi Yamakoshi ,  Koichiro Kishima

    IPC分类号： H04N5/222

    CPC分类号： H04N5/2354 ,  G02B21/0096 ,  G02B21/367 ,  H04N5/2351 ,  H05B33/0818

    摘要： An image acquisition apparatus includes: an imaging device on which an image of a small area allocated to an area to be imaged is formed; a detection section detecting intensity of light irradiated on the small area from a light source; an integration section integrating the intensity of light detected by the detection section; if an integration value of the intensity of light integrated by the integration section from a point in time when light is emitted from the light source is greater than a predetermined threshold value, a light-source control section terminates light emission; an exposure control section starting exposure of the imaging device before light is emitted from the light source and terminating exposure of the imaging device after emission of light from the light source is terminated; and an image acquisition section acquiring the image of the small area as a divided image from the imaging device.

    摘要翻译： 一种图像获取装置，包括：成像装置，在其上形成分配给被成像区域的小区域的图像; 检测部，检测从光源照射在小区域上的光的强度; 积分部，其对由所述检测部检测出的光的强度进行积分; 如果从光源发射光的时间点的积分部分积分的光的积分值大于预定阈值，则光源控制部分终止发光; 曝光控制部分在从光源发射光并且终止来自光源的光的发射之后终止曝光，开始成像装置的曝光; 以及图像获取部，其从所述成像装置获取所述小区域的图像作为分割图像。

    IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION METHOD
    7.
    发明申请
    IMAGE ACQUISITION APPARATUS AND IMAGE ACQUISITION METHOD 有权
    图像获取装置和图像获取方法

    公开(公告)号：US20110037875A1

    公开(公告)日：2011-02-17

    申请号：US12850251

    申请日：2010-08-04

    申请人： Takamichi Yamakoshi ,  Koichiro Kishima

    发明人： Takamichi Yamakoshi ,  Koichiro Kishima

    IPC分类号： H04N5/235

    CPC分类号： H04N5/2354 ,  G02B21/0096 ,  G02B21/367 ,  H04N5/2351 ,  H05B33/0818

    摘要： An image acquisition apparatus includes: an imaging device on which an image of a small area allocated to an area to be imaged is formed; a detection section detecting intensity of light irradiated on the small area from a light source; an integration section integrating the intensity of light detected by the detection section; if an integration value of the intensity of light integrated by the integration section from a point in time when light is emitted from the light source is greater than a predetermined threshold value, a light-source control section terminates light emission; an exposure control section starting exposure of the imaging device before light is emitted from the light source and terminating exposure of the imaging device after emission of light from the light source is terminated; and an image acquisition section acquiring the image of the small area as a divided image from the imaging device.

    摘要翻译： 一种图像获取装置，包括：成像装置，在其上形成分配给被成像区域的小区域的图像; 检测部，检测从光源照射在小区域上的光的强度; 积分部，其对由所述检测部检测出的光的强度进行积分; 如果从光源发射光的时间点的积分部分积分的光的积分值大于预定阈值，则光源控制部分终止发光; 曝光控制部分在从光源发射光并且终止来自光源的光的发射之后终止曝光，开始成像装置的曝光; 以及图像获取部，其从所述成像装置获取所述小区域的图像作为分割图像。

    STAGE CONTROL DEVICE, STAGE CONTROL METHOD, STAGE CONTROL PROGRAM, AND MICROSCOPE
    8.
    发明申请
    STAGE CONTROL DEVICE, STAGE CONTROL METHOD, STAGE CONTROL PROGRAM, AND MICROSCOPE 审中-公开
    阶段控制装置，阶段控制方法，阶段控制程序和显微镜

    公开(公告)号：US20110157349A1

    公开(公告)日：2011-06-30

    申请号：US12972030

    申请日：2010-12-17

    申请人： Takashi Yamamoto ,  Koichiro Kishima ,  Ryu Narusawa ,  Yu Hirono ,  Fumiyasu Suzuki

    发明人： Takashi Yamamoto ,  Koichiro Kishima ,  Ryu Narusawa ,  Yu Hirono ,  Fumiyasu Suzuki

    IPC分类号： H04N7/18 ,  H04N5/225

    CPC分类号： G02B21/26 ,  G01Q30/20 ,  G02B21/006 ,  G02B21/14 ,  G02B21/24 ,  G02B21/36 ,  G02B27/0075

    摘要： A stage control device is provided and includes: an obtaining section obtaining a set of images as different visual points in all or a part of a sample set as a photographing object; a distance calculating section calculating a distance between each pixel of one image to be set as a reference in the set of images and a relative pixel in the other image; a tilt angle calculating section calculating a tilt angle of the sample using the distance calculated by the distance calculating section; and an adjusting section adjusting a tilt angle of a stage surface on which the sample is disposed so as to minimize a tilt within an angle of view of a photographed picture on a basis of the tilt angle of the sample.

    摘要翻译： 提供了一种舞台控制装置，包括：获取部，其在作为拍摄对象的样本集的全部或一部分中获得作为不同视点的一组图像; 距离计算部分，计算要在图像集合中设置为参考的一个图像的每个像素与另一图像中的相对像素之间的距离; 倾斜角计算部，使用由所述距离计算部计算出的距离来计算所述样本的倾斜角度; 以及调整部，其调整配置有所述样本的台面的倾斜角度，以便根据所述样品的倾斜角度使拍摄图像的视角内的倾斜最小化。

    Image processing apparatus and method for generating an image
    9.
    发明授权
    Image processing apparatus and method for generating an image 有权
    用于产生图像的图像处理装置和方法

    公开(公告)号：US09100532B2

    公开(公告)日：2015-08-04

    申请号：US13159067

    申请日：2011-06-13

    申请人： Ryu Narusawa ,  Koichiro Kishima

    发明人： Ryu Narusawa ,  Koichiro Kishima

    IPC分类号： H04N9/083 ,  H04N3/14 ,  H04N5/335 ,  H04N9/04 ,  H04N5/228 ,  H04N9/73

    CPC分类号： H04N9/045 ,  H04N9/735

    摘要： An image processing apparatus includes an output signal obtaining unit that is connected to a pixel group having a first pixel, a second pixel, and a third pixel and obtains a first output signal, a second output signal, and a third output signal, a spectral sensitivity determination unit that determines a first spectral sensitivity, a second spectral sensitivity, and a third spectral sensitivity, which are spectral sensitivities of the first, second, and third output signals, respectively, with respect to a wavelength of incident light entering the pixel group, an output signal amplification unit that amplifies the first, second, and third output signals based on the first, second, and third spectral sensitivities, respectively, and an image generation unit calculates pixel values of the first pixel, the second pixel, and the third pixel from the first output signal, the second output signal, and the third output signal amplified, and generates an image.

    摘要翻译： 一种图像处理装置，包括输出信号获取单元，其连接到具有第一像素，第二像素和第三像素的像素组，并获得第一输出信号，第二输出信号和第三输出信号，光谱 灵敏度确定单元，其分别确定第一，第二和第三输出信号相对于入射到像素组的入射光的波长的光谱灵敏度，第二光谱灵敏度和第三光谱灵敏度 输出信号放大单元，其分别基于第一，第二和第三光谱灵敏度放大第一，第二和第三输出信号，并且图像生成单元计算第一像素，第二像素和 从第一输出信号，第二输出信号和第三输出信号放大第三像素，并产生图像。

    Biological sample image acquiring apparatus, biological sample image acquiring method, and program
    10.
    发明授权
    Biological sample image acquiring apparatus, biological sample image acquiring method, and program 有权
    生物样本图像获取装置，生物样本图像获取方法和程序

    公开(公告)号：US08497899B2

    公开(公告)日：2013-07-30

    申请号：US12652128

    申请日：2010-01-05

    申请人： Koichiro Kishima

    发明人： Koichiro Kishima

    IPC分类号： H04N7/18

    CPC分类号： G02B21/367 ,  G02B21/26 ,  G02B21/362

    摘要： A biological sample image acquiring apparatus includes: a sample stage on which a biological sample is placed and which can move in a direction; an objective lens magnifying a region of the biological sample; an imaging device imaging the region magnified by the objective lens; a stage on which the imaging device or the objective lens is placed and which can move in a corresponding direction of the direction; a first moving mechanism moving the sample stage so that a target region of the biological sample is located at an imaging range; a second moving mechanism moving the stage in the corresponding direction at a movement speed obtained by multiplying a movement speed of the sample stage by a magnification of the objective lens; and an imaging controller starting the exposure of the imaging device before the sample stage moved by the first moving means is stopped.

    摘要翻译： 一种生物样本图像获取装置，包括：样品台，其上放置生物样品并且可沿方向移动; 放大生物样品区域的物镜; 成像装置对由物镜放大的区域成像; 成像装置或物镜放置在其上并可沿相反方向移动的阶段; 第一移动机构，移动所述样本台，使得所述生物样本的目标区域位于成像范围; 第二移动机构，以通过将样品台的移动速度乘以物镜的倍率而获得的移动速度在相应方向上移动平台; 并且停止在由第一移动装置移动的样品台之前开始成像装置的曝光的成像控制器。