公开(公告)号：US08895602B1

公开(公告)日：2014-11-25

申请号：US14013487

申请日：2013-08-29

Applicant: Korea Institute of Science and Technology

Inventor： Ghil Soo Nam ,  Kyung Il Choi ,  Ae Nim Pae ,  Seon Hee Seo ,  Hyun Ah Choo ,  Gyo Chang Keum ,  Jung Hyun Kim

IPC: A61K31/4155 ,  C07D403/12

CPC classification number: C07D403/12 ,  A61K31/4155

Abstract: The present invention relates to a 6-pyrazolylamido-3-substituted azabicyclo[3.1.0]hexane derivatives useful as calcium channel blockers, pharmaceutically acceptable salts thereof and medical use of the calcium channel inhibiting effect of the compounds for treatment of diseases.

Abstract translation: 本发明涉及可用作钙通道阻滞剂的6-吡唑基氨基-3-取代的氮杂双环[3.1.0]己烷衍生物，其药学上可接受的盐，以及该化合物治疗疾病的钙通道抑制作用的医学应用。

公开(公告)号：US12050224B2

公开(公告)日：2024-07-30

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo Nam ,  Hyun Ah Choo ,  Ahmed A. Elbatrawy ,  Gyo Chang Keum ,  Yun Kyung Kim ,  Sung Su Lim ,  Jae Kyun Lee ,  Eun Kyoung Bang

IPC: G01N33/68 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/58

CPC classification number: G01N33/6896 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/582 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.