公开(公告)号：US12050224B2

公开(公告)日：2024-07-30

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo Nam ,  Hyun Ah Choo ,  Ahmed A. Elbatrawy ,  Gyo Chang Keum ,  Yun Kyung Kim ,  Sung Su Lim ,  Jae Kyun Lee ,  Eun Kyoung Bang

IPC: G01N33/68 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/58

CPC classification number: G01N33/6896 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/582 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

公开(公告)号：US20210255203A1

公开(公告)日：2021-08-19

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo NAM ,  Hyun Ah CHOO ,  Ahmed A. Elbatrawy ,  Gyo Chang KEUM ,  Yun Kyung KIM ,  Sung Su LIM ,  Jae Kyun LEE ,  Eun Kyoung BANG

IPC: G01N33/68 ,  C07D215/20 ,  C07D401/06

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.