公开(公告)号：US09980954B2

公开(公告)日：2018-05-29

申请号：US15403404

申请日：2017-01-11

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunah Choo ,  Sun-Joon Min ,  Yun Kyung Kim ,  Hoon Ryu ,  Hyemyung Seo ,  Juhyeon Kim ,  Jihoon Jang ,  Sungsu Lim ,  Younghee Kim ,  Yu Jin Hwang ,  Yong Seo Cho

IPC: A61K31/47 ,  A61K31/4709 ,  A61K31/5377

CPC classification number: A61K31/47 ,  A61K31/4709 ,  A61K31/5377

Abstract: The present disclosure relates to a quinoline derivative which inhibits the activity of histone methyltransferases (ESET/SETDB1) specific for the histone molecule H3K9 or a pharmaceutically acceptable salt thereof and a use thereof.

公开(公告)号：US10544427B2

公开(公告)日：2020-01-28

申请号：US15709822

申请日：2017-09-20

Applicant: Korea Institute of Science and Technology

Inventor： Do Hee Kim ,  Seul Gi Shin ,  Sung Su Lim ,  Ae Nim Pae ,  Dong Jin Kim ,  Yun Kyung Kim

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/47 ,  G01N33/50 ,  G01N33/68

Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.

公开(公告)号：US20180119169A1

公开(公告)日：2018-05-03

申请号：US15709822

申请日：2017-09-20

Applicant: Korea Institute of Science and Technology

Inventor： Do Hee KIM ,  Seul Gi Shin ,  Sung Su Lim ,  Ae Nim Pae ,  Dong Jin Kim ,  Yun Kyung Kim

IPC: C12N15/85 ,  A01K67/027 ,  G01N33/50 ,  C07K14/47 ,  G01N33/68

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0318 ,  C07K14/47 ,  C07K2319/60 ,  C12N2015/8527 ,  C12N2015/8536 ,  C12N2015/859 ,  C12N2830/008 ,  G01N33/5058 ,  G01N33/5088 ,  G01N33/6896 ,  G01N2800/2814

Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.

公开(公告)号：US20150065494A1

公开(公告)日：2015-03-05

申请号：US14389609

申请日：2013-04-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dong Jin Kim ,  Kyung Ho Yoo ,  Young Soo Kim ,  Woong Seo Park ,  Yong Koo Kang ,  Hye Yun Kim ,  Yun Kyung Kim ,  Ki Duk Park ,  Maeng Sup Kim ,  Kwee Hyun Suh ,  Young Gil Ahn

IPC: C07D413/12 ,  C07D405/12 ,  C07D307/81

CPC classification number: C07D413/12 ,  C07D307/81 ,  C07D405/12

Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.

Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。

公开(公告)号：US09962384B1

公开(公告)日：2018-05-08

申请号：US15697728

申请日：2017-09-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Yun Kyung Kim ,  Sung Su Lim ,  Do Hee Kim ,  Md. Mamunul Haque ,  Seul Gi Shin ,  Ha Eun Lee ,  Tae Hun Kim ,  Sang Min Lim ,  Ae Nim Pae

IPC: A61K31/50 ,  A61K47/36 ,  C07D237/10

CPC classification number: A61K31/50 ,  A61K47/36 ,  C07D237/04 ,  C07D237/10

Abstract: Disclosed is a levosimendan compound, an optically active isomer thereof, or a pharmaceutically acceptable salt thereof, which is used for the prevention and/or treatment of diseases caused by tau aggregation or phosphorylation, such as neurodegenerative diseases (e.g., Alzheimer disease). In accordance with yet another aspect of the present invention, there is provided a health functional food for preventing or treating tau aggregation-related diseases, containing a levosimendan compound or a pharmaceutically acceptable salt, stereoisomer or solvate thereof.

公开(公告)号：US11668709B2

公开(公告)日：2023-06-06

申请号：US16579852

申请日：2019-09-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun Lee ,  Ji Yoon Kang ,  Hyewhon Rhim ,  Yi Jae Lee ,  Hyewon Seo ,  Yun Kyung Kim

IPC: G01N33/543 ,  G01N33/68 ,  G16B40/10

CPC classification number: G01N33/54373 ,  G01N33/54326 ,  G01N33/6845 ,  G01N33/6896 ,  G16B40/10 ,  G01N2440/00 ,  G01N2440/14 ,  G01N2440/38 ,  G01N2800/2821

Abstract: The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.

公开(公告)号：US12050224B2

公开(公告)日：2024-07-30

申请号：US17021438

申请日：2020-09-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ghil Soo Nam ,  Hyun Ah Choo ,  Ahmed A. Elbatrawy ,  Gyo Chang Keum ,  Yun Kyung Kim ,  Sung Su Lim ,  Jae Kyun Lee ,  Eun Kyoung Bang

IPC: G01N33/68 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/58

CPC classification number: G01N33/6896 ,  C07D215/20 ,  C07D215/48 ,  C07D401/06 ,  G01N33/582 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

公开(公告)号：US11421237B2

公开(公告)日：2022-08-23

申请号：US16857089

申请日：2020-04-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sung Su Lim ,  Seul Gi Shin ,  Yun Kyung Kim

IPC: C12N15/64 ,  C07K14/47

Abstract: The present disclosure relates to a vector pair for screening TDP-43 (TAR DNA-binding protein 43 or TransActive Response DNA-binding protein 43) oligomer formation, a cell line transfected with the vector pair, and a method of monitoring TDP-43 oligomer formation using the cell line. More specifically, the vector pair includes: a first vector including a first TDP-43 gene and a first fluorescence protein gene; and a second vector including a second TDP-43 gene and a second fluorescence protein gene, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first TDP-43 gene and a protein expressed from the second TDP-43 gene. The vector pair is effective in that it makes it possible to monitor TDP-43 oligomer formation in living cells.

公开(公告)号：US08838197B2

公开(公告)日：2014-09-16

申请号：US13670957

申请日：2012-11-07

Applicant: Korea Institute of Science and Technology

Inventor： Il Joo Cho ,  Eui Sung Yoon ,  Jei Won Cho ,  Myoung Gun Jeon ,  Yun Kyung Kim

IPC: A61B5/0478 ,  A61B5/00

CPC classification number: A61B5/0478 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/125 ,  A61B2562/18

Abstract: The micro probe according to an embodiment of the present disclosure includes: a probe portion made of a rigid material and serving as a portion inserted into the brain; a flexible portion connected to a distal end of the probe portion and made of a flexible material; a soluble portion coated on at least one surface of the flexible portion and made of a material which is dissolved by a solution in the cranium; and a body portion connected to the other end of the flexible portion whose one end is connected to the probe portion.

Abstract translation: 根据本公开的实施例的微型探针包括：由刚性材料制成并用作插入脑中的部分的探针部分; 柔性部分，其连接到探针部分的远端并由柔性材料制成; 所述可溶部分涂覆在所述柔性部分的至少一个表面上，并且由溶液溶解在所述颅骨中的材料制成; 以及主体部分，其连接到柔性部分的另一端，其一端连接到探针部分。