公开(公告)号：US20160139020A1

公开(公告)日：2016-05-19

申请号：US14891465

申请日：2013-05-16

Applicant: L'OREAL

Inventor： Alexandre Nicolas ,  Sébastien Gregoire ,  Christophe Provin ,  Christophe Hadjur ,  Teruo Fujii

IPC: G01N13/00 ,  G01N27/403 ,  G01N27/07 ,  G01N21/84

CPC classification number: G01N13/00 ,  G01N13/04 ,  G01N15/082 ,  G01N21/84 ,  G01N27/07 ,  G01N27/403 ,  G01N2013/003

Abstract: The invention relates to an installation (1) for determining the diffusion profile of at least one molecule through skin, comprising: a microfluidic chip (4) comprising: a donor compartment (10) intended to contain a test solution comprising the or each molecule; a receptor compartment (12) intended to contain a receptor solution; and a membrane (14) with skin-mimetic barrier properties arranged between the donor compartment (10) and the receptor compartment (12) so that the test solution diffuses through the membrane (14) from the donor compartment (10) into the receptor compartment (12); and an analyzer (8) for measuring a physical parameter of the solution contained in the receptor compartment (12) as the test solution diffuses through the membrane (14), and said analyzer (8) being configured for measuring the physical parameter in the receptor compartment (12), the analyzer (8) being further configured for calculating the diffusion profile of the or each molecule through skin from the measured physical parameter.

Abstract translation: 本发明涉及一种用于确定通过皮肤的至少一种分子的扩散分布的装置（1），其包括：微流体芯片（4），包括：供体隔室（10），用于容纳包含所述或每个分子的测试溶液; 旨在含有受体溶液的受体隔室（12）; 以及膜（14），其具有布置在供体室（10）和受体隔室（12）之间的皮肤模拟阻挡性质，使得测试溶液通过膜（14）从供体隔室（10）扩散到受体隔室 （12）; 以及分析器（8），用于当所述测试溶液通过所述膜（14）扩散时，测量包含在所述受体室（12）中的溶液的物理参数，并且所述分析器（8）被配置为测量所述受体中的物理参数 隔室（12），分析器（8）还被配置为从测量的物理参数计算皮肤或每个分子的扩散分布。