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    RESORCINOL DERIVATIVES FOR COSMETIC USE THEREOF
    1.
    发明申请
    RESORCINOL DERIVATIVES FOR COSMETIC USE THEREOF 审中-公开

    公开(公告)号：US20180370886A1

    公开(公告)日：2018-12-27

    申请号：US16061913

    申请日：2016-12-08

    Applicant: L'OREAL

    Inventor： Xavier MARAT ,  Amélie GUEGUINIAT

    IPC: C07C39/11 ,  C07C69/18 ,  C07C69/017 ,  A61Q19/02

    CPC classification number: C07C39/11 ,  A61K8/347 ,  A61K8/375 ,  A61Q19/02 ,  C07C69/18

    Abstract: The present invention relates to a compound of formula (I), in particular for the use thereof for depigmenting, lightering and/or bleaching the skin. (I) In which R1 and R2, which may be identical or different, denote hydrogen, or a COR5 radical in which R5 denotes a linear C1-C10 or branched C3-C10 alkyl radical, preferably a linear C1-C6 or branched C3-C6 alkyl radical, more preferentially a linear C1-C4 alkyl radical, R3 denotes a linear C1-C6 or branched C3-C6 alkyl radical, preferably a linear C1-C4 or branched C3-C4 alkyl radical, and R4 denotes H, a linear C1-C6 or branched C3-C6 alkyl radical, or a COR5 radical, and also the salts thereof, the solvates thereof and the optical isomers thereof, and the racemic mixtures thereof, alone or as a mixture. The present invention also relates to the novel compounds (I) and also to the process for preparing same and to a cosmetic process for depigmenting the skin using such compounds (I).

    PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS
    3.
    发明申请
    PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS 审中-公开
    使用噻吗啉酮化合物制备克拉霉素材料的方法

    公开(公告)号：US20160045420A1

    公开(公告)日：2016-02-18

    申请号：US14804531

    申请日：2015-07-21

    Applicant: L'OREAL

    Inventor： Xavier MARAT

    IPC: A61K8/49 ,  A61Q19/02 ,  C07D213/82

    CPC classification number: A61K8/4926 ,  A61K8/4933 ,  A61Q19/02 ,  C07D213/82

    Abstract: The invention relates to a cosmetic process for depigmenting, lightening and/or whitening keratin materials, in particular the skin, which comprises the application of a cosmetic composition comprising a compound of formula (I): or its tautomer form of formula (I′): in which: R1 and R2, which may be identical or different, denote a radical chosen from: a) a hydrogen atom; b) a C1-C20 alkyl group optionally interrupted with N, S or O, optionally substituted with one or more group(s) chosen from —OR3, —SR3, —NR3R4, —CONHR3; -COOR3; and an aryl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; c) a C1-C8 alkyl group substituted with a C5-C12 aryl radical optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; d) a phenyl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; R3 denoting H or a C1-C5 alkyl group, R4 denoting H, a C1-C5 hydrocarbon-based group or an acetyl group; it being possible for R1 and R2 to form, with the nitrogen atom which bears them, a ring chosen from pyrrolidine, pyrroline, piperidine, piperazine, morpholine, thiomorpholine and azepine. The invention also relates to the cosmetic use of a compound (I) or (I′) as a whitening, lightening and/or depigmenting agent for keratin materials.

    Abstract translation: 本发明涉及一种用于脱色，减轻和/或增白角蛋白材料，特别是皮肤的美容方法，其包括施用包含式（I）化合物或其式（I'）的互变异构体的化妆品组合物： 其中：R1和R2可以相同或不同，表示选自以下的基团：a）氢原子; b）任选地被N，S或O中断的任选被一个或多个选自-OR 3，-SR 3，-NR 3 R 4，-CONHR 3的基团取代的C 1 -C 20烷基; -COOR3; 和任选被一个或多个羟基和/或与一个或多个C 1 -C 8烷氧基取代的芳基; c）被任选被一个或多个羟基和/或一个或多个C 1 -C 8烷氧基取代的C 5 -C 12芳基取代的C 1 -C 8烷基; d）任选被一个或多个羟基和/或与一个或多个C 1 -C 8烷氧基取代的苯基; R3表示H或C1-C5烷基，R4表示H，C1-C5烃基或乙酰基; R 1和R 2可以与带有它们的氮原子一起形成选自吡咯烷，吡咯啉，哌啶，哌嗪，吗啉，硫代吗啉和氮杂的环。 本发明还涉及化合物（I）或（I'）作为角蛋白材料的增白，减轻和/或脱色剂的美容用途。

    PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS
    6.
    发明公开
    PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING THIOPYRIDINONE COMPOUNDS 审中-公开

    公开(公告)号：US20240293301A1

    公开(公告)日：2024-09-05

    申请号：US18652169

    申请日：2024-05-01

    Applicant: L'OREAL

    Inventor： Xavier MARAT

    IPC: A61K8/49 ,  A61Q19/02 ,  C07D213/82

    CPC classification number: A61K8/4926 ,  A61K8/4933 ,  A61Q19/02 ,  C07D213/82

    Abstract: The invention relates to a cosmetic process for depigmenting, lightening and/or whitening keratin materials, in particular the skin, which comprises the application of a cosmetic composition comprising a compound of formula (I):






    or its tautomer form of formula (I′):










    in which:
    R1 and R2, which may be identical or different, denote a radical chosen from:
    a) a hydrogen atom;
    b) a C1-C20 alkyl group optionally interrupted with N, S or O, optionally substituted with one or more group(s) chosen from —OR3, —SR3, —NR3R4, —CONHR3; —COOR3; and an aryl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals;




    c) a C1-C8 alkyl group substituted with a C5-C12 aryl radical optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals;
    d) a phenyl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals;
    R3 denoting H or a C1-C5 alkyl group,
    R4 denoting H, a C1-C5 hydrocarbon-based group or an acetyl group;



    it being possible for R1 and R2 to form, with the nitrogen atom which bears them, a ring chosen from pyrrolidine, pyrroline, piperidine, piperazine, morpholine, thiomorpholine and azepine.




    The invention also relates to the cosmetic use of a compound (I) or (I′) as a whitening, lightening and/or depigmenting agent for keratin materials.

    RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE
    7.
    发明申请
    RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE 审中-公开

    公开(公告)号：US20200246240A1

    公开(公告)日：2020-08-06

    申请号：US16650645

    申请日：2018-09-27

    Applicant: L'OREAL

    Inventor： Xavier MARAT ,  Chunyu MA

    IPC: A61K8/49 ,  A61K45/06 ,  A61Q19/02 ,  C07D233/64 ,  C07D235/12 ,  C07D277/64 ,  C07D263/32 ,  C07D263/57 ,  C07D277/24

    Abstract: The invention relates to resorcinol-based compounds of formula (I), to the salts, solvates, optical and/or geometrical isomers thereof, to the use thereof as active agents for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or of the colour of the semi-mucous membranes. The invention also relates to a non-therapeutic cosmetic treatment process for depigmenting, lightening and/or bleaching keratin materials, and/or for preventing, reducing and/or treating impairment of the skin complexion or the colour of the semi-mucous membranes. Formula (I)

    XYLOSIDE DERIVATIVES OF RESVERATROL FOR USE THEREOF IN COSMETICS
    8.
    发明申请
    XYLOSIDE DERIVATIVES OF RESVERATROL FOR USE THEREOF IN COSMETICS 有权

    公开(公告)号：US20210052479A1

    公开(公告)日：2021-02-25

    申请号：US16955616

    申请日：2018-12-20

    Applicant: L'OREAL

    Inventor： Xavier MARAT ,  Maria DALKO

    IPC: A61K8/60 ,  A61Q19/08 ,  C07H15/203

    Abstract: The present invention relates to the use of a compound of formula (I): in which R1, R2 and R3 independently denote: —a group of formula (II), or —a hydrogen atom H, it being understood that at least one of the radicals R1, R2, R3 denotes a group of formula (II); and also the salts thereof, the solvates thereof, and/or the isomers thereof, for preventing and/or cosmetically treating the signs of skin aging.

    HYDROXYLATED AMIDE SKIN MOISTURIZER
    10.
    发明申请
    HYDROXYLATED AMIDE SKIN MOISTURIZER 有权
    羟化皮肤滋润剂

    公开(公告)号：US20130053342A1

    公开(公告)日：2013-02-28

    申请号：US13658235

    申请日：2012-10-23

    Applicant: L'OREAL

    Inventor： Xavier MARAT

    IPC: A61K8/42 ,  A61K8/49 ,  A61Q19/00 ,  C07D207/08 ,  A61K8/92 ,  C07F7/10 ,  C07C235/06 ,  A61K8/58 ,  A61K8/97

    CPC classification number: C07D207/08 ,  A61K8/42 ,  A61K8/44 ,  A61K8/4913 ,  A61K8/55 ,  A61K8/585 ,  A61Q19/00 ,  A61Q19/007 ,  C07C235/06 ,  C07C235/08 ,  C07C235/12 ,  C07F7/081

    Abstract: The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): with (i) R1 and R2 represent a hydrogen atom or a C1-C6 alkyl group, or (ii) R1 and R2 can form, together with the nitrogen atom which bears them, a saturated heterocycle with 5 to 7 ring members; R5 representing a hydrogen atom or a (C1-C3) alkyl group; R6 representing a hydrogen atom or a (C1-C4) alkyl group; R3 represents a hydrogen atom or a (C1-C6) alkyl group, or —OR3 represents a phosphate group; it being possible for the two groups R3 to form, together, an isopropylidene group; R4 represents a hydrogen atom or —OR4 represents a phosphate group; and the salts, solvates and isomers thereof. The invention also relates to a cosmetic composition comprising a compound (I) and the corresponding new compounds.

    Abstract translation: 本发明涉及式（I）化合物作为皮肤保湿剂的美容用途：（i）R1和R2表示氢原子或C1-C6烷基，或（ii）R1和R2可以形成 与带有它们的氮原子一起形成具有5至7个环成员的饱和杂环; R5表示氢原子或（C1-C3）烷基; R6表示氢原子或（C1-C4）烷基; R3表示氢原子或（C1-C6）烷基，或-OR3表示磷酸基; 两组R3可能一起形成异丙叉基; R4表示氢原子或-OR4表示磷酸基; 及其盐，溶剂化物和异构体。 本发明还涉及包含化合物（I）和相应的新化合物的化妆品组合物。

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