公开(公告)号：US09422504B2

公开(公告)日：2016-08-23

申请号：US14368895

申请日：2012-12-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand

IPC: C11B1/00 ,  C11B1/06 ,  A23L1/30 ,  A61K36/54 ,  C11B1/04 ,  C11B1/10 ,  C11B1/08 ,  A23L1/212

CPC classification number: C11B1/06 ,  A23L19/00 ,  A23L33/105 ,  A23L33/115 ,  A61K36/54 ,  C11B1/04 ,  C11B1/08 ,  C11B1/10 ,  C11B1/102

Abstract: The present invention relates to the use of whole soft avocados to obtain an avocado oil rich in unsaponifiable, said unsaponifiable containing aliphatic acetogenins and/or their derivatives. Advantageously, the oil has an acid value less than or equal to 3 mgKOH/g. The invention also relates to a process for obtaining an avocado oil rich in unsaponifiable from whole soft avocados. said unsaponifiable containing aliphatic acetogenins and/or their derivatives. The invention also relates to an avocado oil rich in unsaponifiable obtainable by this process. The invention also relates to the use of the avocado oil to prepare a concentrate of avocado oil enriched in unsaponifiable or an avocado unsaponifiable rich in aliphatic furans. Finally, the invention relates to an avocado unsaponifiable rich in aliphatic furans or a concentrate of avocado oil enriched in unsaponifiable, obtainable from said avocado oil, for its use as a drug, advantageously in the prevention and/or the treatment of connective tissue disorders such as arthrosis, articular pathologies such as rhumatisms, or parodontal disorders, such as gingivitis or parodontitis.

Abstract translation: 本发明涉及使用整个软的鳄梨来获得富含不皂化的所述不皂化的含脂肪酸乙偶姻和/或其衍生物的鳄梨油。 有利地，油的酸值小于或等于3mgKOH / g。 本发明还涉及一种从整个软鳄梨中获得不可皂化的鳄梨油的方法。 所述不可皂化的含脂肪族乙酰胆酸和/或其衍生物。 本发明还涉及一种富含不可皂化的鳄梨油，可通过该方法获得。 本发明还涉及鳄梨油用于制备富含不可皂化的鳄梨油的浓缩物或不可皂化的富含脂肪族呋喃的鳄梨油。 最后，本发明涉及不可皂化的富含脂肪呋喃的鳄梨或富含不皂化油的鳄梨油浓缩物，可从所述鳄梨油获得，用于药物，有利地用于预防和/或治疗结缔组织疾病，例如 作为关节病，关节病变如眩晕症或传染疾病，例如牙龈炎或牙菌斑。

公开(公告)号：US09439938B2

公开(公告)日：2016-09-13

申请号：US14370892

申请日：2013-01-14

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

IPC: A61K36/54 ,  A23L1/30 ,  A23D9/00 ,  A23D9/02 ,  C11B1/08 ,  A61K31/01 ,  A61K31/575

CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

公开(公告)号：US20150005273A1

公开(公告)日：2015-01-01

申请号：US14370892

申请日：2013-01-14

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

IPC: A61K36/54 ,  A61K31/575 ,  A61K31/01

CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

公开(公告)号：US20140357879A1

公开(公告)日：2014-12-04

申请号：US14368895

申请日：2012-12-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand

IPC: C11B1/06

CPC classification number: C11B1/06 ,  A23L19/00 ,  A23L33/105 ,  A23L33/115 ,  A61K36/54 ,  C11B1/04 ,  C11B1/08 ,  C11B1/10 ,  C11B1/102

Abstract: The present invention relates to the use of whole soft avocados for preparing avocado oil rich in unsaponifiables, said unsaponifiables containing aliphatic acetogenins and/or derivatives thereof. Advantageously, the oil has an acid value of less than or equal to 3 mg KOH/g. The invention further relates to a method for preparing avocado oil rich in unsaponifiables from whole soft avocados, said unsaponifiables containing aliphatic acetogenins and/or derivatives thereof. The invention further relates to avocado oil which is rich in unsaponifiables and which can be prepared by said method. The invention further relates to the use of the avocado oil for preparing an avocado oil concentrate enriched with unsaponifiables, or avocado unsaponifiables that are rich in aliphatic furans. Finally, the invention relates to avocado unsaponifiables which are rich in aliphatic furans or to an avocado oil concentrate which is enriched with unsaponifiables, and which can be prepared from said avocado oil, for the use thereof as a drug, advantageously for the prevention and/or treatment of disorders of the conjunctive tissue, such as arthrosis, joint conditions, such as rheumatism, or periodontal diseases, such as gingivitis or periodontitis.

Abstract translation: 本发明涉及用于制备富含不皂化物的鳄梨油的所述软的鳄梨油，所述不可皂化物含有脂族乙酰胆碱和/或其衍生物。 有利地，油的酸值小于或等于3mg KOH / g。 本发明还涉及一种制备富含不可皂化物的鳄梨油的方法，该方法包括脂肪族乙酰胆碱和/或其衍生物。 本发明还涉及富含不皂化物并且可以通过所述方法制备的鳄梨油。 本发明还涉及鳄梨油用于制备富含不可皂化物的鳄梨油浓缩物或富含脂肪族呋喃的鳄梨不皂化物的用途。 最后，本发明涉及富含脂肪族呋喃的鳄梨不可皂化物或富含不皂化物的鳄梨油浓缩物，并且其可由所述鳄梨油制备用于药物，有利地用于预防和/ 或治疗结膜组织疾病，如关节病，关节病，如风湿病，牙周病如牙龈炎或牙周炎。

公开(公告)号：US09416333B2

公开(公告)日：2016-08-16

申请号：US14371057

申请日：2013-01-14

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

IPC: A01N65/00 ,  C11B1/06 ,  A23L1/30 ,  A61K36/54 ,  A23L1/212 ,  A23D9/007 ,  A23D9/02 ,  C11B1/08 ,  A61Q19/06 ,  A61Q19/08 ,  A61K8/92 ,  A23L2/52

CPC classification number: C11B1/06 ,  A23D9/007 ,  A23D9/02 ,  A23L2/52 ,  A23L19/07 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K8/922 ,  A61K36/54 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/08

Abstract: The present invention relates to the use of avocado seeds in order to obtain avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado oil enriched in alkyl polyols or acetylated derivatives thereof from at least avocado seeds, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable by the present method. The invention also relates to the use of avocado oil in order to prepare an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, or to prepare an avocado unsaponifiable enriched in alkyl polyols. Lastly, the invention relates to an avocado unsaponifiable enriched in alkyl polyols or an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable from said avocado oil, for use as a drug, advantageously in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

Abstract translation: 本发明涉及鳄梨种子的使用以获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及从至少鳄梨种子获得富含烷基多元醇或其乙酰化衍生物的鳄梨油的方法，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及通过本方法获得的富含烷基多元醇和/或其乙酰化衍生物的鳄梨油。 本发明还涉及鳄梨油的用途，以制备富含烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，或制备不可皂化的富含烷基多元醇的鳄梨油。 最后，本发明涉及一种不可皂化的富含鳄梨油的富含烷基多元醇的牛油果油或富含其烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，其可从所述鳄梨油获得，有利地用于预防和/或治疗 结膜组织疾病如关节病，关节病变如风湿病，或牙周病如牙龈炎或牙周炎。