公开(公告)号：US10682364B2

公开(公告)日：2020-06-16

申请号：US16554603

申请日：2019-08-28

Applicant: LEO Pharma A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22 ,  B65D83/20 ,  B65D83/14

Abstract: A Pharmaceutical Spray Composition Comprising a Vitamin D Analogue and a CorticosteroidThe present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US20150196646A1

公开(公告)日：2015-07-16

申请号：US14410489

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K47/32 ,  A61K47/22 ,  A61K47/10 ,  A61K31/573 ,  A61K47/14

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.

Abstract translation: 用于真皮施用的成膜药物组合物包含溶解在挥发性溶剂中的至少一种治疗活性成分，所述组合物还包含成膜聚合物，增塑剂和油性释放增强剂。 组合物能够在皮肤上施用和蒸发溶剂后形成包含成膜聚合物和增塑剂的连续相和包含油性释放增强剂的液滴的分散相。

公开(公告)号：US20180078498A1

公开(公告)日：2018-03-22

申请号：US15562278

申请日：2016-03-16

Applicant: LEO Pharma A/S

Inventor： Karsten Petersson ,  Karen Margrethe Engell ,  Jorgen Jansson ,  Kim Troensegaard Nielsen ,  Andre Huss Eriksson ,  Anne Moore ,  Sonja Vucen ,  Caroline O'Sullivan ,  Abina Crean

IPC: A61K9/00 ,  A61K31/573 ,  A61K31/59 ,  A61K47/34 ,  A61K47/32 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K31/573 ,  A61K31/59 ,  A61K31/593 ,  A61K47/32 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61K2300/00

Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.

公开(公告)号：US20150157729A1

公开(公告)日：2015-06-11

申请号：US14412978

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K47/44 ,  A61K47/38 ,  A61K47/32 ,  A61K47/14 ,  B65D83/14 ,  A61K47/08 ,  A61K47/06 ,  A61K31/573 ,  A61K9/00 ,  A61K9/12 ,  A61K47/10

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract translation: 用于真皮施用的可喷雾成膜药物组合物包含溶解在选自二甲醚，二乙醚和甲基乙醚的药学上可接受的推进剂中的至少一种治疗活性成分，以及二甲醚，二乙醚和甲基乙基醚的混合物，以及 选自C3-5烷烃，氢氟烷烃，氢氯烃，氟代烷烃和氯氟烷烃的第二推进剂，推进剂的含量为组合物的50-99.5％w / w，组合物还包含成膜聚合物，增塑剂和 油性释放增强剂。

公开(公告)号：US09566286B2

公开(公告)日：2017-02-14

申请号：US14707662

申请日：2015-05-08

Applicant: LEO PHARMA A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/57 ,  A61K31/58 ,  A61M35/00 ,  A61K31/573 ,  A61K31/593

CPC classification number: A61K31/593 ,  A61K9/0014 ,  A61K9/122 ,  A61K9/124 ,  A61K31/573 ,  A61K31/58 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61K47/14 ,  A61K47/22 ,  A61M11/00 ,  A61M35/003 ,  A61M2210/04 ,  B65D83/207 ,  B65D83/752 ,  A61K2300/00

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analog and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract translation: 本发明涉及包含生物活性维生素D衍生物或类似物和皮质类固醇的局部喷雾组合物及其在治疗真皮疾病和病症中的用途。

公开(公告)号：US10716799B2

公开(公告)日：2020-07-21

申请号：US16554586

申请日：2019-08-28

Applicant: LEO Pharma A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22 ,  B65D83/20 ,  B65D83/14

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US10688108B2

公开(公告)日：2020-06-23

申请号：US16554539

申请日：2019-08-28

Applicant: LEO Pharma A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22 ,  B65D83/20 ,  B65D83/14

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US10660908B2

公开(公告)日：2020-05-26

申请号：US16135366

申请日：2018-09-19

Applicant: LEO Pharma A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22 ,  B65D83/20 ,  B65D83/14

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US10130640B2

公开(公告)日：2018-11-20

申请号：US14707733

申请日：2015-05-08

Applicant: LEO PHARMA A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22 ,  B65D83/20 ,  B65D83/14

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analog and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US09345774B2

公开(公告)日：2016-05-24

申请号：US14412978

申请日：2013-07-05

Applicant: LEO PHARMA A/S

Inventor： Karsten Petersson ,  Kit Frederiksen ,  Diana Omkvist ,  Jörgen Jansson

IPC: A61K9/00 ,  A61K47/32 ,  A61K9/70 ,  A61K9/12 ,  A61K31/573 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/44 ,  B65D83/14 ,  A61K47/22

CPC classification number: A61K31/573 ,  A61K9/0014 ,  A61K9/124 ,  A61K9/7015 ,  A61K47/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  B65D83/752

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract translation: 用于真皮施用的可喷雾成膜药物组合物包含溶解在选自二甲醚，二乙醚和甲基乙醚的药学上可接受的推进剂中的至少一种治疗活性成分，以及二甲醚，二乙醚和甲基乙基醚的混合物，以及 选自C3-5烷烃，氢氟烷烃，氢氯烃，氟代烷烃和氯氟烷烃的第二推进剂，推进剂的含量为组合物的50-99.5％w / w，组合物还包含成膜聚合物，增塑剂和 油性释放增强剂。