公开(公告)号：US20190390270A1

公开(公告)日：2019-12-26

申请号：US16246990

申请日：2019-01-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Dennis Lehto ,  Steven J. Boege

IPC: C12Q1/6874 ,  B01L7/00 ,  B01L3/00 ,  G01N21/05

Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

公开(公告)号：US11371093B2

公开(公告)日：2022-06-28

申请号：US16246990

申请日：2019-01-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Dennis Lehto ,  Steven J. Boege

IPC: C12Q1/6874 ,  B01L3/00 ,  B01L7/00 ,  G01N21/05 ,  G03B27/42 ,  B01L9/00 ,  G01N15/14 ,  G01N21/03

Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

公开(公告)号：US10184149B2

公开(公告)日：2019-01-22

申请号：US14997956

申请日：2016-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Dennis Lehto ,  Steven J. Boege

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/6874 ,  G01N21/05 ,  G03B27/42 ,  B01L9/00 ,  G01N15/14 ,  G01N21/03

Abstract: A device for performing biological sample reactions may include a plurality of flow cells configured to be mounted to a common microscope translation stage, wherein each flow cell is configured to receive at least one sample holder containing biological sample. Each flow cell also may be configured to be selectively placed in an open position for positioning the at least one sample holder into the flow cell and a closed position for reacting biological sample contained in the at least one sample holder. The plurality of flow cells may be configured to be selectively placed in the open position and the closed position independently of each other.

公开(公告)号：US10107758B2

公开(公告)日：2018-10-23

申请号：US14323203

申请日：2014-07-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Mark F. Oldham ,  Eric S. Nordman ,  Hongye Sun ,  Steven J. Boege

IPC: G01N21/64

Abstract: A scanning detection system is provided wherein emissions from locations in a flow cell are detected. In some embodiments, the system can comprise an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided.